A metabolomic analysis of thiol response for standard and modified N‐acetyl cysteine treatment regimens in patients with acetaminophen overdose
N‐acetylcysteine (NAC) is an antidote to prevent acetaminophen (paracetamol‐APAP)‐induced acute liver injury (ALI). The 3‐bag licensed 20.25 h standard regimen, and a 12 h modified regimen, are used to treat APAP overdose. This study evaluated the redox thiol response and APAP metabolites, in patien...
Uloženo v:
| Vydáno v: | Clinical and translational science Ročník 14; číslo 4; s. 1476 - 1489 |
|---|---|
| Hlavní autoři: | , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
United States
John Wiley & Sons, Inc
01.07.2021
John Wiley and Sons Inc Wiley |
| Témata: | |
| ISSN: | 1752-8054, 1752-8062, 1752-8062 |
| On-line přístup: | Získat plný text |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Abstract | N‐acetylcysteine (NAC) is an antidote to prevent acetaminophen (paracetamol‐APAP)‐induced acute liver injury (ALI). The 3‐bag licensed 20.25 h standard regimen, and a 12 h modified regimen, are used to treat APAP overdose. This study evaluated the redox thiol response and APAP metabolites, in patients with a single APAP overdose treated with either the 20.25 h standard or 12 h modified regimen. We used liquid chromatography tandem mass spectrometry to quantify clinically important oxidative stress biomarkers and APAP metabolites in plasma samples from 45 patients who participated in a randomized controlled trial (SNAP trial). We investigated the time course response of plasma metabolites at predose, 12 h, and 20.25 h post‐start of NAC infusion. The results showed that the 12 h modified regimen resulted in a significant elevation of plasma NAC and cysteine concentrations at 12 h post‐infusion. We found no significant alteration in the metabolism of APAP, mitochondrial, amino acids, and other thiol biomarkers with the two regimens. We examined APAP and purine metabolism in overdose patients who developed ALI. We showed the major APAP‐metabolites and xanthine were significantly higher in patients with ALI. These biomarkers correlated well with alanine aminotransferase activity at admission. Receiver operating characteristic analysis showed that at admission, plasma APAP‐metabolites and xanthine concentrations were predictive for ALI. In conclusion, a significantly higher redox thiol response with the modified NAC regimen at 12 h postdose suggests this regimen may produce greater antioxidant efficacy. At baseline, plasma APAP and purine metabolites may be useful biomarkers for early prediction of APAP‐induced ALI. |
|---|---|
| AbstractList | N-acetylcysteine (NAC) is an antidote to prevent acetaminophen (paracetamol-APAP)-induced acute liver injury (ALI). The 3-bag licensed 20.25 h standard regimen, and a 12 h modified regimen, are used to treat APAP overdose. This study evaluated the redox thiol response and APAP metabolites, in patients with a single APAP overdose treated with either the 20.25 h standard or 12 h modified regimen. We used liquid chromatography tandem mass spectrometry to quantify clinically important oxidative stress biomarkers and APAP metabolites in plasma samples from 45 patients who participated in a randomized controlled trial (SNAP trial). We investigated the time course response of plasma metabolites at predose, 12 h, and 20.25 h post-start of NAC infusion. The results showed that the 12 h modified regimen resulted in a significant elevation of plasma NAC and cysteine concentrations at 12 h post-infusion. We found no significant alteration in the metabolism of APAP, mitochondrial, amino acids, and other thiol biomarkers with the two regimens. We examined APAP and purine metabolism in overdose patients who developed ALI. We showed the major APAP-metabolites and xanthine were significantly higher in patients with ALI. These biomarkers correlated well with alanine aminotransferase activity at admission. Receiver operating characteristic analysis showed that at admission, plasma APAP-metabolites and xanthine concentrations were predictive for ALI. In conclusion, a significantly higher redox thiol response with the modified NAC regimen at 12 h postdose suggests this regimen may produce greater antioxidant efficacy. At baseline, plasma APAP and purine metabolites may be useful biomarkers for early prediction of APAP-induced ALI. N‐acetylcysteine (NAC) is an antidote to prevent acetaminophen (paracetamol‐APAP)‐induced acute liver injury (ALI). The 3‐bag licensed 20.25 h standard regimen, and a 12 h modified regimen, are used to treat APAP overdose. This study evaluated the redox thiol response and APAP metabolites, in patients with a single APAP overdose treated with either the 20.25 h standard or 12 h modified regimen. We used liquid chromatography tandem mass spectrometry to quantify clinically important oxidative stress biomarkers and APAP metabolites in plasma samples from 45 patients who participated in a randomized controlled trial (SNAP trial). We investigated the time course response of plasma metabolites at predose, 12 h, and 20.25 h post‐start of NAC infusion. The results showed that the 12 h modified regimen resulted in a significant elevation of plasma NAC and cysteine concentrations at 12 h post‐infusion. We found no significant alteration in the metabolism of APAP, mitochondrial, amino acids, and other thiol biomarkers with the two regimens. We examined APAP and purine metabolism in overdose patients who developed ALI. We showed the major APAP‐metabolites and xanthine were significantly higher in patients with ALI. These biomarkers correlated well with alanine aminotransferase activity at admission. Receiver operating characteristic analysis showed that at admission, plasma APAP‐metabolites and xanthine concentrations were predictive for ALI. In conclusion, a significantly higher redox thiol response with the modified NAC regimen at 12 h postdose suggests this regimen may produce greater antioxidant efficacy. At baseline, plasma APAP and purine metabolites may be useful biomarkers for early prediction of APAP‐induced ALI. N ‐acetylcysteine (NAC) is an antidote to prevent acetaminophen (paracetamol‐APAP)‐induced acute liver injury (ALI). The 3‐bag licensed 20.25 h standard regimen, and a 12 h modified regimen, are used to treat APAP overdose. This study evaluated the redox thiol response and APAP metabolites, in patients with a single APAP overdose treated with either the 20.25 h standard or 12 h modified regimen. We used liquid chromatography tandem mass spectrometry to quantify clinically important oxidative stress biomarkers and APAP metabolites in plasma samples from 45 patients who participated in a randomized controlled trial (SNAP trial). We investigated the time course response of plasma metabolites at predose, 12 h, and 20.25 h post‐start of NAC infusion. The results showed that the 12 h modified regimen resulted in a significant elevation of plasma NAC and cysteine concentrations at 12 h post‐infusion. We found no significant alteration in the metabolism of APAP, mitochondrial, amino acids, and other thiol biomarkers with the two regimens. We examined APAP and purine metabolism in overdose patients who developed ALI. We showed the major APAP‐metabolites and xanthine were significantly higher in patients with ALI. These biomarkers correlated well with alanine aminotransferase activity at admission. Receiver operating characteristic analysis showed that at admission, plasma APAP‐metabolites and xanthine concentrations were predictive for ALI. In conclusion, a significantly higher redox thiol response with the modified NAC regimen at 12 h postdose suggests this regimen may produce greater antioxidant efficacy. At baseline, plasma APAP and purine metabolites may be useful biomarkers for early prediction of APAP‐induced ALI. N-acetylcysteine (NAC) is an antidote to prevent acetaminophen (paracetamol-APAP)-induced acute liver injury (ALI). The 3-bag licensed 20.25 h standard regimen, and a 12 h modified regimen, are used to treat APAP overdose. This study evaluated the redox thiol response and APAP metabolites, in patients with a single APAP overdose treated with either the 20.25 h standard or 12 h modified regimen. We used liquid chromatography tandem mass spectrometry to quantify clinically important oxidative stress biomarkers and APAP metabolites in plasma samples from 45 patients who participated in a randomized controlled trial (SNAP trial). We investigated the time course response of plasma metabolites at predose, 12 h, and 20.25 h post-start of NAC infusion. The results showed that the 12 h modified regimen resulted in a significant elevation of plasma NAC and cysteine concentrations at 12 h post-infusion. We found no significant alteration in the metabolism of APAP, mitochondrial, amino acids, and other thiol biomarkers with the two regimens. We examined APAP and purine metabolism in overdose patients who developed ALI. We showed the major APAP-metabolites and xanthine were significantly higher in patients with ALI. These biomarkers correlated well with alanine aminotransferase activity at admission. Receiver operating characteristic analysis showed that at admission, plasma APAP-metabolites and xanthine concentrations were predictive for ALI. In conclusion, a significantly higher redox thiol response with the modified NAC regimen at 12 h postdose suggests this regimen may produce greater antioxidant efficacy. At baseline, plasma APAP and purine metabolites may be useful biomarkers for early prediction of APAP-induced ALI.N-acetylcysteine (NAC) is an antidote to prevent acetaminophen (paracetamol-APAP)-induced acute liver injury (ALI). The 3-bag licensed 20.25 h standard regimen, and a 12 h modified regimen, are used to treat APAP overdose. This study evaluated the redox thiol response and APAP metabolites, in patients with a single APAP overdose treated with either the 20.25 h standard or 12 h modified regimen. We used liquid chromatography tandem mass spectrometry to quantify clinically important oxidative stress biomarkers and APAP metabolites in plasma samples from 45 patients who participated in a randomized controlled trial (SNAP trial). We investigated the time course response of plasma metabolites at predose, 12 h, and 20.25 h post-start of NAC infusion. The results showed that the 12 h modified regimen resulted in a significant elevation of plasma NAC and cysteine concentrations at 12 h post-infusion. We found no significant alteration in the metabolism of APAP, mitochondrial, amino acids, and other thiol biomarkers with the two regimens. We examined APAP and purine metabolism in overdose patients who developed ALI. We showed the major APAP-metabolites and xanthine were significantly higher in patients with ALI. These biomarkers correlated well with alanine aminotransferase activity at admission. Receiver operating characteristic analysis showed that at admission, plasma APAP-metabolites and xanthine concentrations were predictive for ALI. In conclusion, a significantly higher redox thiol response with the modified NAC regimen at 12 h postdose suggests this regimen may produce greater antioxidant efficacy. At baseline, plasma APAP and purine metabolites may be useful biomarkers for early prediction of APAP-induced ALI. Abstract N‐acetylcysteine (NAC) is an antidote to prevent acetaminophen (paracetamol‐APAP)‐induced acute liver injury (ALI). The 3‐bag licensed 20.25 h standard regimen, and a 12 h modified regimen, are used to treat APAP overdose. This study evaluated the redox thiol response and APAP metabolites, in patients with a single APAP overdose treated with either the 20.25 h standard or 12 h modified regimen. We used liquid chromatography tandem mass spectrometry to quantify clinically important oxidative stress biomarkers and APAP metabolites in plasma samples from 45 patients who participated in a randomized controlled trial (SNAP trial). We investigated the time course response of plasma metabolites at predose, 12 h, and 20.25 h post‐start of NAC infusion. The results showed that the 12 h modified regimen resulted in a significant elevation of plasma NAC and cysteine concentrations at 12 h post‐infusion. We found no significant alteration in the metabolism of APAP, mitochondrial, amino acids, and other thiol biomarkers with the two regimens. We examined APAP and purine metabolism in overdose patients who developed ALI. We showed the major APAP‐metabolites and xanthine were significantly higher in patients with ALI. These biomarkers correlated well with alanine aminotransferase activity at admission. Receiver operating characteristic analysis showed that at admission, plasma APAP‐metabolites and xanthine concentrations were predictive for ALI. In conclusion, a significantly higher redox thiol response with the modified NAC regimen at 12 h postdose suggests this regimen may produce greater antioxidant efficacy. At baseline, plasma APAP and purine metabolites may be useful biomarkers for early prediction of APAP‐induced ALI. |
| Author | Ng, Mei Li Leroy Sivappiragasam, Pakkiri Bateman, D. Nicholas Ibrahim, Baharudin Khoo, Benjamin Bing Jie Choi, Hyungwon Dear, James W Drum, Chester Lee |
| AuthorAffiliation | 3 Department of Medicine Yong Loo Lin School of Medicine National University of Singapore Singapore City Singapore 6 School of Pharmaceutical Sciences Universiti Sains Malaysia Kepala Batas Malaysia 1 Pharmacology, Toxicology, and Therapeutics Centre for Cardiovascular Science University of Edinburgh Edinburgh UK 5 Institute of Molecular and Cell Biology Agency for Science, Technology, and Research Singapore City Singapore 2 Cardiovascular Research Institute National University Health System Singapore City Singapore 7 Department of Surgery Yong Loo Lin School of Medicine National University of Singapore Singapore City Singapore 8 Department of Biochemistry Yong Loo Lin School of Medicine National University of Singapore Singapore City Singapore 4 Advanced Medical and Dental Institute Universiti Sains Malaysia Kepala Batas Malaysia |
| AuthorAffiliation_xml | – name: 2 Cardiovascular Research Institute National University Health System Singapore City Singapore – name: 4 Advanced Medical and Dental Institute Universiti Sains Malaysia Kepala Batas Malaysia – name: 7 Department of Surgery Yong Loo Lin School of Medicine National University of Singapore Singapore City Singapore – name: 1 Pharmacology, Toxicology, and Therapeutics Centre for Cardiovascular Science University of Edinburgh Edinburgh UK – name: 3 Department of Medicine Yong Loo Lin School of Medicine National University of Singapore Singapore City Singapore – name: 5 Institute of Molecular and Cell Biology Agency for Science, Technology, and Research Singapore City Singapore – name: 8 Department of Biochemistry Yong Loo Lin School of Medicine National University of Singapore Singapore City Singapore – name: 6 School of Pharmaceutical Sciences Universiti Sains Malaysia Kepala Batas Malaysia |
| Author_xml | – sequence: 1 givenname: James W surname: Dear fullname: Dear, James W organization: University of Edinburgh – sequence: 2 givenname: Mei Li surname: Ng fullname: Ng, Mei Li organization: Universiti Sains Malaysia – sequence: 3 givenname: D. Nicholas surname: Bateman fullname: Bateman, D. Nicholas organization: University of Edinburgh – sequence: 4 givenname: Pakkiri surname: Leroy Sivappiragasam fullname: Leroy Sivappiragasam, Pakkiri organization: National University Health System – sequence: 5 givenname: Hyungwon surname: Choi fullname: Choi, Hyungwon organization: Agency for Science, Technology, and Research – sequence: 6 givenname: Benjamin Bing Jie surname: Khoo fullname: Khoo, Benjamin Bing Jie organization: National University of Singapore – sequence: 7 givenname: Baharudin surname: Ibrahim fullname: Ibrahim, Baharudin organization: Universiti Sains Malaysia – sequence: 8 givenname: Chester Lee surname: Drum fullname: Drum, Chester Lee email: mdccld@nus.edu.sg organization: National University of Singapore |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33742775$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9ks1u3CAQgK0qVfPTHvoCFVIv6WETDMbGl0rRqj-RovbQ9IwwjHdZYXCBTeRbH6F9xT5JcTZdNZFaLiD45mNg5rg4cN5BUbws8VmZx7lK8aykGLdPiqOyYWTBcU0O9mtWHRbHMW4wrmnN2bPikNKmIk3DjoqfF2iAJDtv_WAUkk7aKZqIfI_S2niLAsTRuwio9wHFJJ2WQWdOo8Fr0xvQ6NOv7z-kgjRZpKaYwDhAKYBMA7iUBSuTFxEZh0aZTN6L6NakNZpj5GCcH9fgkL-BoH2E58XTXtoIL-7nk-Lr-3fXy4-Lq88fLpcXVwvFcNsueKu1JhWDFkhPmNQaesWg01Bnr8Ykn1e1ZAqwbjSUmpO25k2nmw4D5j09KS53Xu3lRozBDDJMwksj7jZ8WAkZklEWhMKatrzlTVn1VQdSclbRmhJQ-W_zDdn1ducat90AWuU3BmkfSB-eOLMWK38jOMUla6ssOL0XBP9tCzGJwUQF1koHfhsFYZhWFeFkRl8_Qjd-G3LdZirn1VBal5l69XdG-1T-VD4Db3aACj7GAP0eKbGYu0rkrhJ3XZXZ80esMimX0s-PMfZ_EbfGwvRvtVhef9lF_Aauy-On |
| CitedBy_id | crossref_primary_10_1038_s41392_024_02072_z crossref_primary_10_1002_iub_2625 crossref_primary_10_1016_j_jaci_2022_07_025 crossref_primary_10_1016_j_ecoenv_2022_113773 crossref_primary_10_1124_dmd_121_000455 crossref_primary_10_1080_17425255_2023_2259787 crossref_primary_10_1016_j_dsx_2024_103068 crossref_primary_10_1039_D3SC00224A |
| Cites_doi | 10.1016/j.tox.2020.152493 10.1172/JCI104186 10.1089/ars.2015.6317 10.1002/cpt1974164676 10.1186/1471-230X-11-20 10.1007/s00204-013-1118-1 10.1016/j.cca.2008.06.020 10.1016/0041-008X(89)90283-4 10.1016/S0140-6736(13)62062-0 10.1007/s11357-011-9218-4 10.1016/j.bbagen.2013.04.014 10.1111/j.1572-0241.2001.03700.x 10.1186/2050-6511-14-20 10.1124/jpet.110.166421 10.1039/C8RA02178C 10.1124/dmd.104.003095 10.1111/bcp.12789 10.1080/10715762.2018.1468564 10.1007/BF01373017 10.1155/2013/615754 10.1016/S0731-7085(03)00573-9 10.1016/j.redox.2018.04.019 10.1016/j.freeradbiomed.2019.05.035 10.1080/03602532.2017.1354014 10.1016/S0021-9258(19)39733-9 10.1016/j.eclinm.2019.04.005 10.1007/s10565-011-9208-4 10.1016/j.bbadis.2014.05.022 10.1007/s00726-018-2613-8 10.2174/0929867323666160725091915 10.1002/cpt.541 10.1056/NEJMct0708278 10.1111/j.1478-3231.2004.0906.x 10.1016/j.anireprosci.2007.12.003 10.1053/j.gastro.2006.01.033 10.1007/s00204-016-1745-4 |
| ContentType | Journal Article |
| Copyright | 2021 The Authors. published by Wiley Periodicals LLC on behalf of the American Society for Clinical Pharmacology and Therapeutics. 2021 The Authors. Clinical and Translational Science published by Wiley Periodicals LLC on behalf of the American Society for Clinical Pharmacology and Therapeutics. 2021. This work is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| Copyright_xml | – notice: 2021 The Authors. published by Wiley Periodicals LLC on behalf of the American Society for Clinical Pharmacology and Therapeutics. – notice: 2021 The Authors. Clinical and Translational Science published by Wiley Periodicals LLC on behalf of the American Society for Clinical Pharmacology and Therapeutics. – notice: 2021. This work is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| DBID | 24P AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7QP 7T5 7TK 7TM 7U9 7X7 7XB 8FD 8FE 8FH 8FI 8FJ 8FK ABUWG AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. LK8 M0S M7N M7P P64 PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS RC3 7X8 5PM DOA |
| DOI | 10.1111/cts.13009 |
| DatabaseName | Wiley Online Library Open Access CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Calcium & Calcified Tissue Abstracts Immunology Abstracts Neurosciences Abstracts Nucleic Acids Abstracts Virology and AIDS Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Technology Research Database ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials Biological Science Collection ProQuest Central Natural Science Collection ProQuest One Community College ProQuest Central Engineering Research Database Proquest Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Biological Sciences ProQuest Health & Medical Collection Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Biotechnology and BioEngineering Abstracts ProQuest Central Premium ProQuest One Academic (New) ProQuest Publicly Available Content ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Publicly Available Content Database ProQuest Central Student Technology Research Database ProQuest One Academic Middle East (New) ProQuest Central Essentials Nucleic Acids Abstracts ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Central China ProQuest Central ProQuest One Applied & Life Sciences ProQuest Health & Medical Research Collection Genetics Abstracts Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Collection AIDS and Cancer Research Abstracts ProQuest Central (New) Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection Neurosciences Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Immunology Abstracts Engineering Research Database ProQuest One Academic Calcium & Calcified Tissue Abstracts ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE Publicly Available Content Database CrossRef MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: 24P name: Wiley Online Library Open Access url: https://authorservices.wiley.com/open-science/open-access/browse-journals.html sourceTypes: Publisher – sequence: 2 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 3 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 4 dbid: PIMPY name: Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| DocumentTitleAlternate | Thiol Response in Standard and Modified NAC Regimen |
| EISSN | 1752-8062 |
| EndPage | 1489 |
| ExternalDocumentID | oai_doaj_org_article_c0d39898714f4beaa8543632ec0545ce PMC8301594 33742775 10_1111_cts_13009 CTS13009 |
| Genre | article Randomized Controlled Trial Research Support, Non-U.S. Gov't Journal Article Clinical Trial, Phase IV |
| GeographicLocations | United Kingdom--UK Scotland |
| GeographicLocations_xml | – name: United Kingdom--UK – name: Scotland |
| GrantInformation_xml | – fundername: Clinician Scientist Award (CSA) – fundername: National Research Foundation – fundername: National Medical Research Council of the Singapore Ministry of Health funderid: CSAINV17nov12 – fundername: National Medical Research Council of the Singapore Ministry of Health grantid: CSAINV17nov12 |
| GroupedDBID | --- 05W 0R~ 10A 1OC 24P 29B 31~ 4.4 52S 53G 5GY 5VS 7X7 8-1 8FE 8FH 8FI 8FJ AAHHS AANHP AAZKR ABDBF ABUWG ACBWZ ACCFJ ACCMX ACRPL ACUHS ACXQS ACYXJ ADKYN ADNMO ADZMN ADZOD AEEZP AEQDE AFBPY AFKRA AFZJQ AIWBW AJBDE ALIPV ALMA_UNASSIGNED_HOLDINGS ALUQN AVUZU BBNVY BDRZF BENPR BHPHI BPHCQ BRXPI BVXVI CAG CCPQU COF CS3 DIK EBD EBS EJD EMOBN ESX F5P FEDTE FYUFA G-S GODZA GROUPED_DOAJ HCIFZ HMCUK HVGLF HYE HZ~ IAO IHR ITC KQ8 LH4 LK8 LW6 M7P MY~ O9- OIG OK1 P2P PIMPY PQQKQ PROAC QB0 ROL RPM SUPJJ SV3 TUS UKHRP WIN XG1 AAYXX AFFHD AGQPQ CITATION PHGZM PHGZT PQGLB CGR CUY CVF ECM EIF NPM 3V. 7QP 7T5 7TK 7TM 7U9 7XB 8FD 8FK AZQEC DWQXO FR3 GNUQQ H94 K9. M7N P64 PJZUB PKEHL PPXIY PQEST PQUKI PRINS RC3 7X8 PUEGO 5PM |
| ID | FETCH-LOGICAL-c5099-89ddd245e9e2f25addefc5ebde6aced029dd46a5ce0d7de1d829687bd7b0e08f3 |
| IEDL.DBID | DOA |
| ISICitedReferencesCount | 9 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000638284100001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1752-8054 1752-8062 |
| IngestDate | Mon Nov 10 04:35:26 EST 2025 Tue Nov 04 01:38:41 EST 2025 Thu Oct 02 05:49:33 EDT 2025 Tue Oct 07 06:40:15 EDT 2025 Mon Jul 21 06:00:26 EDT 2025 Tue Nov 18 21:45:36 EST 2025 Sat Nov 29 02:23:12 EST 2025 Wed Jan 22 16:57:23 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 4 |
| Language | English |
| License | Attribution-NonCommercial 2021 The Authors. Clinical and Translational Science published by Wiley Periodicals LLC on behalf of the American Society for Clinical Pharmacology and Therapeutics. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c5099-89ddd245e9e2f25addefc5ebde6aced029dd46a5ce0d7de1d829687bd7b0e08f3 |
| Notes | Funding information James W. Dear and Mei Li Ng contributed equally to this work. This study was generously supported by the Clinician Scientist Award (CSA) grant, National Medical Research Council of the Singapore Ministry of Health [CSAINV17nov12], and National Research Foundation, under its artificial intelligence (AI) Singapore Programme (AISG Award No: AISG‐GC‐2019‐002). Correction added on 20 April, 2021, after first online publication: The author name Bing Jie Khoo has been corrected as Benjamin Bing Jie Khoo in the author byline. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Article-2 ObjectType-Feature-1 content type line 23 ObjectType-Undefined-3 |
| OpenAccessLink | https://doaj.org/article/c0d39898714f4beaa8543632ec0545ce |
| PMID | 33742775 |
| PQID | 2554373361 |
| PQPubID | 2029979 |
| PageCount | 14 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_c0d39898714f4beaa8543632ec0545ce pubmedcentral_primary_oai_pubmedcentral_nih_gov_8301594 proquest_miscellaneous_2503442824 proquest_journals_2554373361 pubmed_primary_33742775 crossref_primary_10_1111_cts_13009 crossref_citationtrail_10_1111_cts_13009 wiley_primary_10_1111_cts_13009_CTS13009 |
| PublicationCentury | 2000 |
| PublicationDate | July 2021 |
| PublicationDateYYYYMMDD | 2021-07-01 |
| PublicationDate_xml | – month: 07 year: 2021 text: July 2021 |
| PublicationDecade | 2020 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: Hoboken |
| PublicationTitle | Clinical and translational science |
| PublicationTitleAlternate | Clin Transl Sci |
| PublicationYear | 2021 |
| Publisher | John Wiley & Sons, Inc John Wiley and Sons Inc Wiley |
| Publisher_xml | – name: John Wiley & Sons, Inc – name: John Wiley and Sons Inc – name: Wiley |
| References | 1974; 16 2013; 1830 2019; 11 2017; 49 1988; 59 2004; 24 1960; 39 2008; 109 2006; 130 2011; 11 2020; 441 2019; 140 2014; 1842 2012; 34 1990; 265 2014; 88 2015; 23 2018; 17 2018; 8 2017; 91 2013; 14 1989; 101 2013; 2013 2004; 34 2010; 333 1997; 12 2008; 359 2018; 52 2012; 28 2016; 81 2018; 50 1990; 255 2017; 101 2014; 383 2008; 396 2005; 33 2001; 96 2016; 23 e_1_2_9_30_1 e_1_2_9_31_1 e_1_2_9_11_1 e_1_2_9_34_1 e_1_2_9_10_1 e_1_2_9_35_1 e_1_2_9_13_1 e_1_2_9_32_1 e_1_2_9_12_1 e_1_2_9_33_1 Gale GR (e_1_2_9_36_1) 1988; 59 e_1_2_9_15_1 e_1_2_9_14_1 e_1_2_9_39_1 e_1_2_9_17_1 e_1_2_9_16_1 e_1_2_9_37_1 e_1_2_9_19_1 e_1_2_9_18_1 Jaeschke H (e_1_2_9_38_1) 1990; 255 e_1_2_9_20_1 e_1_2_9_22_1 e_1_2_9_21_1 e_1_2_9_24_1 e_1_2_9_23_1 e_1_2_9_8_1 e_1_2_9_7_1 e_1_2_9_6_1 e_1_2_9_5_1 e_1_2_9_4_1 e_1_2_9_3_1 e_1_2_9_2_1 e_1_2_9_9_1 e_1_2_9_26_1 e_1_2_9_25_1 e_1_2_9_28_1 e_1_2_9_27_1 e_1_2_9_29_1 |
| References_xml | – volume: 52 start-page: 751 year: 2018 end-page: 762 article-title: N‐Acetylcysteine as an antioxidant and disulphide breaking agent: the reasons why publication-title: Free Radical Res. – volume: 33 start-page: 1867 year: 2005 end-page: 1876 article-title: Bioactivation of 4‐methylphenol (p‐cresol) via cytochrome p450‐mediated aromatic oxidation in human liver microsomes publication-title: Drug Metab Dispos – volume: 50 start-page: 1377 year: 2018 end-page: 1390 article-title: Acetaminophen reduces the protein levels of high affinity amino acid permeases and causes tryptophan depletion publication-title: Amino Acids – volume: 39 start-page: 1633 year: 1960 end-page: 1638 article-title: The concentrations of cysteine and cystine in human blood plasma publication-title: J Clin Invest – volume: 383 start-page: 697 year: 2014 end-page: 704 article-title: Reduction of adverse effects from intravenous acetylcysteine treatment for paracetamol poisoning: a randomised controlled trial publication-title: Lancet – volume: 101 start-page: 531 year: 2017 end-page: 540 article-title: Circulating acetaminophen metabolites are toxicokinetic biomarkers of acute liver injury publication-title: Clin Pharmacol Ther – volume: 16 start-page: 676 year: 1974 end-page: 684 article-title: Acetaminophen‐induced hepatic injury: Protective role of glutathione in man and rationale for therapy publication-title: Clin Pharmacol Ther – volume: 109 start-page: 88 year: 2008 end-page: 99 article-title: Metabolic requirements associated with GSH synthesis during in vitro maturation of cattle oocytes publication-title: Anim Reprod Sci – volume: 96 start-page: 1194 year: 2001 end-page: 1199 article-title: Serum xanthine oxidase in human liver disease publication-title: Am J Gastroenterol – volume: 91 start-page: 1385 year: 2017 end-page: 1400 article-title: A multicenter assessment of single‐cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity publication-title: Arch Toxicol – volume: 8 start-page: 23230 year: 2018 end-page: 23240 article-title: Bioactive properties: enhancement of hepatoprotective, antioxidant and DNA damage protective effects of golden grey mullet protein hydrolysates against paracetamol toxicity publication-title: RSC Adv – volume: 17 start-page: 274 year: 2018 end-page: 283 article-title: Mechanisms of acetaminophen‐induced liver injury and its implications for therapeutic interventions publication-title: Redox Biol – volume: 396 start-page: 43 year: 2008 end-page: 48 article-title: A rapid LC‐FTMS method for the analysis of cysteine, cystine and cysteine/cystine steady‐state redox potential in human plasma publication-title: Clin Chim Acta – volume: 265 start-page: 3059 year: 1990 end-page: 3065 article-title: Acetaminophen‐induced oxidation of protein thiols. Contribution of impaired thiol‐metabolizing enzymes and the breakdown of adenine nucleotides publication-title: J Biol Chem – volume: 1842 start-page: 1502 year: 2014 end-page: 1517 article-title: Pathophysiology of circulating xanthine oxidoreductase: new emerging roles for a multi‐tasking enzyme publication-title: Biochim Biophys Acta – volume: 24 start-page: 85 year: 2004 end-page: 89 article-title: Apoptosis and necrosis in liver disease publication-title: Liver Int – volume: 130 start-page: 687 year: 2006 end-page: 694 article-title: Measurement of serum acetaminophen‐protein adducts in patients with acute liver failure publication-title: Gastroenterology – volume: 34 start-page: 181 year: 2012 end-page: 193 article-title: Therapeutic paracetamol treatment in older persons induces dietary and metabolic modifications related to sulfur amino acids publication-title: Age (Dordr) – volume: 14 start-page: 20 year: 2013 article-title: Scottish and Newcastle antiemetic pre‐treatment for paracetamol poisoning study (SNAP) publication-title: BMC Pharmacol Toxicol – volume: 23 start-page: 4027 year: 2016 end-page: 4036 article-title: Xanthine oxidoreductase in drug metabolism: beyond a role as a detoxifying enzyme publication-title: Curr Med Chem – volume: 441 start-page: 152493 year: 2020 article-title: Mechanism‐based identification of plasma metabolites associated with liver toxicity publication-title: Toxicology – volume: 59 start-page: 305 year: 1988 end-page: 320 article-title: Interaction of caffeine with acetaminophen in mice: schedule dependency of the antagonism by caffeine of acetaminophen hepatotoxicity and the effects of caffeine metabolites, allopurinol, and diethyl ether publication-title: Res Commun Chem Pathol Pharmacol. – volume: 88 start-page: 391 year: 2014 end-page: 401 article-title: Circulating acylcarnitines as biomarkers of mitochondrial dysfunction after acetaminophen overdose in mice and humans publication-title: Arch Toxicol – volume: 12 start-page: 373 year: 1997 end-page: 377 article-title: Amino acids and plasma antioxidant capacity publication-title: Amino Acids – volume: 101 start-page: 356 year: 1989 end-page: 369 article-title: Effects of sulfur‐amino acid‐deficient diets on acetaminophen metabolism and hepatotoxicity in rats publication-title: Toxicol Appl Pharmacol – volume: 2013 start-page: 615754 year: 2013 article-title: An amino acids mixture improves the hepatotoxicity induced by acetaminophen in mice publication-title: J Amino Acids – volume: 11 start-page: 20 year: 2011 article-title: Acetaminophen‐cysteine adducts during therapeutic dosing and following overdose publication-title: BMC Gastroenterol – volume: 28 start-page: 69 year: 2012 end-page: 87 article-title: Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins publication-title: Cell Biol Toxicol – volume: 333 start-page: 939 year: 2010 end-page: 947 article-title: Oxidation of plasma cysteine/cystine and GSH/GSSG redox potentials by acetaminophen and sulfur amino acid insufficiency in humans publication-title: J Pharmacol Exp Ther – volume: 81 start-page: 471 year: 2016 end-page: 481 article-title: Evidence for the changing regimens of acetylcysteine publication-title: Br J Clin Pharmacol – volume: 34 start-page: 585 year: 2004 end-page: 593 article-title: The quantification of paracetamol, paracetamol glucuronide and paracetamol sulphate in plasma and urine using a single high‐performance liquid chromatography assay publication-title: J Pharm Biomed Anal – volume: 1830 start-page: 4943 year: 2013 end-page: 4959 article-title: Glutathione metabolism modeling: a mechanism for liver drug‐robustness and a new biomarker strategy publication-title: Biochem Biophys Acta – volume: 11 start-page: 11 year: 2019 end-page: 17 article-title: Safety and efficacy of the SNAP 12‐hour acetylcysteine regimen for the treatment of paracetamol overdose publication-title: EClinicalMedicine – volume: 140 start-page: 14 year: 2019 end-page: 27 article-title: The role of thiols in antioxidant systems publication-title: Free Radic Biol Med – volume: 23 start-page: 1144 year: 2015 end-page: 1170 article-title: Clinical relevance of biomarkers of oxidative stress publication-title: Antioxid Redox Signal – volume: 359 start-page: 285 year: 2008 end-page: 292 article-title: Acetylcysteine for acetaminophen poisoning publication-title: N Engl J Med – volume: 49 start-page: 395 year: 2017 end-page: 437 article-title: Paracetamol: overdose‐induced oxidative stress toxicity, metabolism, and protective effects of various compounds in vivo and in vitro publication-title: Drug Metab Rev – volume: 255 start-page: 935 year: 1990 end-page: 941 article-title: Glutathione disulfide formation and oxidant stress during acetaminophen‐induced hepatotoxicity in mice in vivo: the protective effect of allopurinol publication-title: J Pharmacol Exp Ther – ident: e_1_2_9_37_1 doi: 10.1016/j.tox.2020.152493 – ident: e_1_2_9_14_1 doi: 10.1172/JCI104186 – ident: e_1_2_9_25_1 doi: 10.1089/ars.2015.6317 – ident: e_1_2_9_33_1 doi: 10.1002/cpt1974164676 – ident: e_1_2_9_30_1 doi: 10.1186/1471-230X-11-20 – ident: e_1_2_9_10_1 doi: 10.1007/s00204-013-1118-1 – ident: e_1_2_9_15_1 doi: 10.1016/j.cca.2008.06.020 – ident: e_1_2_9_22_1 doi: 10.1016/0041-008X(89)90283-4 – ident: e_1_2_9_5_1 doi: 10.1016/S0140-6736(13)62062-0 – ident: e_1_2_9_17_1 doi: 10.1007/s11357-011-9218-4 – ident: e_1_2_9_21_1 doi: 10.1016/j.bbagen.2013.04.014 – ident: e_1_2_9_39_1 doi: 10.1111/j.1572-0241.2001.03700.x – ident: e_1_2_9_9_1 doi: 10.1186/2050-6511-14-20 – ident: e_1_2_9_16_1 doi: 10.1124/jpet.110.166421 – ident: e_1_2_9_23_1 doi: 10.1039/C8RA02178C – ident: e_1_2_9_29_1 doi: 10.1124/dmd.104.003095 – ident: e_1_2_9_7_1 doi: 10.1111/bcp.12789 – ident: e_1_2_9_8_1 doi: 10.1080/10715762.2018.1468564 – ident: e_1_2_9_26_1 doi: 10.1007/BF01373017 – ident: e_1_2_9_28_1 doi: 10.1155/2013/615754 – ident: e_1_2_9_31_1 doi: 10.1016/S0731-7085(03)00573-9 – volume: 59 start-page: 305 year: 1988 ident: e_1_2_9_36_1 article-title: Interaction of caffeine with acetaminophen in mice: schedule dependency of the antagonism by caffeine of acetaminophen hepatotoxicity and the effects of caffeine metabolites, allopurinol, and diethyl ether publication-title: Res Commun Chem Pathol Pharmacol. – ident: e_1_2_9_4_1 doi: 10.1016/j.redox.2018.04.019 – ident: e_1_2_9_13_1 doi: 10.1016/j.freeradbiomed.2019.05.035 – ident: e_1_2_9_24_1 doi: 10.1080/03602532.2017.1354014 – ident: e_1_2_9_35_1 doi: 10.1016/S0021-9258(19)39733-9 – ident: e_1_2_9_6_1 doi: 10.1016/j.eclinm.2019.04.005 – ident: e_1_2_9_19_1 doi: 10.1007/s10565-011-9208-4 – ident: e_1_2_9_34_1 doi: 10.1016/j.bbadis.2014.05.022 – ident: e_1_2_9_20_1 doi: 10.1007/s00726-018-2613-8 – ident: e_1_2_9_12_1 doi: 10.2174/0929867323666160725091915 – ident: e_1_2_9_11_1 doi: 10.1002/cpt.541 – volume: 255 start-page: 935 year: 1990 ident: e_1_2_9_38_1 article-title: Glutathione disulfide formation and oxidant stress during acetaminophen‐induced hepatotoxicity in mice in vivo: the protective effect of allopurinol publication-title: J Pharmacol Exp Ther – ident: e_1_2_9_3_1 doi: 10.1056/NEJMct0708278 – ident: e_1_2_9_2_1 doi: 10.1111/j.1478-3231.2004.0906.x – ident: e_1_2_9_27_1 doi: 10.1016/j.anireprosci.2007.12.003 – ident: e_1_2_9_32_1 doi: 10.1053/j.gastro.2006.01.033 – ident: e_1_2_9_18_1 doi: 10.1007/s00204-016-1745-4 |
| SSID | ssj0063685 |
| Score | 2.2957563 |
| Snippet | N‐acetylcysteine (NAC) is an antidote to prevent acetaminophen (paracetamol‐APAP)‐induced acute liver injury (ALI). The 3‐bag licensed 20.25 h standard... N ‐acetylcysteine (NAC) is an antidote to prevent acetaminophen (paracetamol‐APAP)‐induced acute liver injury (ALI). The 3‐bag licensed 20.25 h standard... N-acetylcysteine (NAC) is an antidote to prevent acetaminophen (paracetamol-APAP)-induced acute liver injury (ALI). The 3-bag licensed 20.25 h standard... N‐acetylcysteine (NAC) is an antidote to prevent acetaminophen (paracetamol‐APAP)‐induced acute liver injury (ALI). The 3‐bag licensed 20.25 h standard... N-acetylcysteine (NAC) is an antidote to prevent acetaminophen (paracetamol-APAP)-induced acute liver injury (ALI). The 3-bag licensed 20.25 h standard... Abstract N‐acetylcysteine (NAC) is an antidote to prevent acetaminophen (paracetamol‐APAP)‐induced acute liver injury (ALI). The 3‐bag licensed 20.25 h... |
| SourceID | doaj pubmedcentral proquest pubmed crossref wiley |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 1476 |
| SubjectTerms | Acetaminophen Acetaminophen - pharmacokinetics Acetaminophen - poisoning Acetylcysteine Acetylcysteine - administration & dosage Adult Alanine Alanine transaminase Analgesics Antidotes - administration & dosage Antioxidants Biomarkers Biomarkers - blood Biomarkers - metabolism Chemical and Drug Induced Liver Injury - blood Chemical and Drug Induced Liver Injury - diagnosis Chemical and Drug Induced Liver Injury - etiology Chemical and Drug Induced Liver Injury - prevention & control Clinical trials Cysteine Drug Administration Schedule Drug Monitoring - methods Drug Overdose - blood Drug Overdose - drug therapy Drug Overdose - etiology Female Humans Infusions, Intravenous Liquid chromatography Liver Male Mass spectroscopy Metabolism Metabolites Metabolomics Middle Aged Mitochondria Nonsteroidal anti-inflammatory drugs Overdose Oxidation-Reduction - drug effects Oxidative stress Paracetamol Patients Plasma Regulatory agencies ROC Curve Sulfhydryl Compounds - blood Sulfhydryl Compounds - metabolism |
| SummonAdditionalLinks | – databaseName: Biological Science Database dbid: M7P link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Nb9QwELWgIMSF749AQQZx6CUisZ3EOaFSUXFhVYki9RY59oRG2k3KJkXixk-Av8gvYcbrBFYULtyi9awVy8-TF_vlDWMvFHIgTUa3UoKMVa4grpEVxLUwxroUEmWMLzZRLBb65KQ8ChtuQ5BVTjnRJ2rXW9ojf4nUl1x4ZJ6-OvsUU9UoOl0NJTQusyvkkiC9dO9oysQ5mav7DyIzXPXITYKzECl57Dj4Qsjl1vPI2_ZfxDX_lEz-TmX9s-jw5v-O4ha7EVgo39_A5ja7BN0ddu1dOGe_y77v8xWMiI8lfbTMTXAu4X3Dx9O2X_L1RloLHDkvn7YjMM7xVe_aBnktX_z4-s1YGL8suSW7aOyYz7J2TgUh8GLgbceDt-vAaVOY03_Mqu3I8KDjpDB1_QD32IfDN8cHb-NQvCG2Gbl-6tI5J1QGJYhGZJRGG5tB7SDHflwisF3lJrOQuMIBIkaUuS5qV9QJJLqR99lO13fwkHGTNHWeapMaAcjebNkkFjNR2mhlpQYdsb1pCisbnM2pwMaymt5wcLb9uV0Zsedz6NnGzuOioNeEgzmAHLj9D_36YxUWdGUTJ6n2ZpGqRtVgjMaZzaUAi0DDUUVsd0JAFdLCUP2a_og9m5txQdMpjemgP6cYcmHEN2EVsQcb0M13ImWhRFFkESu24Lh1q9stXXvqTcM1ZvKsxD73PHD_Pvrq4Pi9v3j07xE8ZtcF6Xu8dHmX7Yzrc3jCrtrPYzusn_qF-BOalkGe priority: 102 providerName: ProQuest – databaseName: Wiley Online Library Open Access dbid: 24P link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Nb9QwEB2VghAXvj8CBRnEoZeVEttJHHEqFRUXqkoUqbfIsSc00m6CNikSN34C_EV-CTPeJOqKIiFxi9YTK86-mTzb4zcArzVxIMNCt0qhWuhM46IiVrCopLXOJxhra0Oxifz42JydFSc78GY6C7PRh5gX3NgzQrxmB7dVf8nJ3dCHUsbFNbieJMpw3QapT6YwnLGyejgNmZLLEzEZZYU4jWe-detjFDT7ryKaf-ZLXuax4UN0dOe_hnAXbo_8UxxsAHMPdrC9Dzc_jDvsD-DngVjhQMhY8nFlYUfNEtHVYjhvuqVYb5JqURDbFdNCBNl5sep8UxOjFce_vv-wDodvS-FYKJo6FnNCu-BSEHTRi6YVo6prL3g5WPA9dtW0LHXQCs4t9V2PD-HT0bvTw_eLsWzDwqWs92kK773UKRYoa5lyAK1dipXHjPrxsaR2ndnUYexzj4QVWWQmr3xexRibWj2C3bZr8QkIG9dVlhibWInE21xRx45iUFIb7ZRBE8H-9P-VbtQ059Iay3Ka29ArDjt2RQSvZtMvGyGPq4zeMghmA9beDj9068_l6Mqli73iqpt5omtdobUm1SpTEh2hjEYVwd4EoXIMCH1JMzcWkVJZEsHLuZlcmfdnbIvdBduw_iLNgXUEjzeIm59EqVzLPE8jyLewuPWo2y1tcx7kwg3F8LSgPvcDFv8--vLw9GO4ePrvps_gluQsn5DAvAe7w_oCn8MN93Vo-vWL4JG_AfIXPuQ priority: 102 providerName: Wiley-Blackwell |
| Title | A metabolomic analysis of thiol response for standard and modified N‐acetyl cysteine treatment regimens in patients with acetaminophen overdose |
| URI | https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fcts.13009 https://www.ncbi.nlm.nih.gov/pubmed/33742775 https://www.proquest.com/docview/2554373361 https://www.proquest.com/docview/2503442824 https://pubmed.ncbi.nlm.nih.gov/PMC8301594 https://doaj.org/article/c0d39898714f4beaa8543632ec0545ce |
| Volume | 14 |
| WOSCitedRecordID | wos000638284100001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1752-8062 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0063685 issn: 1752-8054 databaseCode: DOA dateStart: 20160101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 1752-8062 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0063685 issn: 1752-8054 databaseCode: M7P dateStart: 20160201 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1752-8062 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0063685 issn: 1752-8054 databaseCode: 7X7 dateStart: 20160201 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1752-8062 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0063685 issn: 1752-8054 databaseCode: BENPR dateStart: 20160201 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database customDbUrl: eissn: 1752-8062 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0063685 issn: 1752-8054 databaseCode: PIMPY dateStart: 20160201 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest – providerCode: PRVWIB databaseName: Wiley Online Library Free Content customDbUrl: eissn: 1752-8062 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0063685 issn: 1752-8054 databaseCode: WIN dateStart: 20080101 isFulltext: true titleUrlDefault: https://onlinelibrary.wiley.com providerName: Wiley-Blackwell – providerCode: PRVWIB databaseName: Wiley Online Library Open Access customDbUrl: eissn: 1752-8062 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0063685 issn: 1752-8054 databaseCode: 24P dateStart: 20080101 isFulltext: true titleUrlDefault: https://authorservices.wiley.com/open-science/open-access/browse-journals.html providerName: Wiley-Blackwell |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3NbtQwELagRYgL4rcEysogDr2sSBwndo5t1YoeGq2giOUUOfZEjbSboE2KxI1HgFfkSZhxsquuKOLCJUriieV4xuPP8eQbxt5IxECaiG7jGOKpTCVMS0QF01IYY10EoTTGJ5tQea7n82x2LdUXxYQN9MBDx721oYspx6GKZCVLMEYnMk5jARbBRmKBvC-invViavDBKdGq-18hExzvKDhyClEMj-07nwI525qJPGH_TSjzz2DJ6yDWz0KnD9j9ET7yw6HZD9ktaB6xu-fjBvlj9vOQL6FHxS7ob2NuRsoR3la8v6zbBV8NMbHAEazy9XcElHN82bq6QkDK81_ffxgL_bcFt8TzjBXzTTw6p0wOeNLxuuEjKWvH6Wsup2fMsm6IqaDhFBrq2g6esI-nJxfH76Zj1oWpTYiuU2fOOSETyEBUIiH_V9kESgcp1uNCgeUyNdj1oVMOUNUiS7UqnSpDCHUVP2U7TdvAM8ZNWJVppE1kBCDsslkVWnQhUaWljTXogB2sNVDYkZKcMmMsivXSBJXlN9yygL3eiH4ZeDhuEjoiNW4EiDrb30CDKkaDKv5lUAHbXxtBMY7nrsCFF3FAxWkUsFebYhyJtL1iGmivSIboE3EJKwO2N9jMpiVxrKRQKgmY2rKmraZulzT1pWf71uiCkwzrPPB29_e3L44vPviT5_-jG16we4LCd3xk8j7b6VdX8JLdsV_7ultN2G0hZ3hUc-WPesJ2j07y2fuJH4cTCqHF8t3Z2fnsM159Ost_A5PGO0g |
| linkProvider | Directory of Open Access Journals |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V3NbtQwELbKFgEX_n8CBQwCqZeIxHES54BQKVRdtbtaiUUqp-DYDo20m5RNCuqNR4AX4aF4EmacZGFF4dYDt2g9a9nJ5_Fne_wNIU84cCCBQrdBYAKXR9y4GbACN2NSKu0bj0tpk03E47E4OEgma-R7fxcGwyp7n2gdta4U7pE_A-qLKjxB5L84-uhi1ig8Xe1TaLSw2DMnn2HJVj8fvoLv-5SxndfT7V23yyrgqhDlKEWitWY8NIlhOQtxfOcqNJk2kVRGewzKeSRDZTwdawNdYUkk4kzHmWc8kQdQ7zmyzgHsYkDWJ8PR5F3v-yOUc7dXMEPwM8CGOi0jjB1STW1TLycrM6BNFHAau_0zSPN38mxnv50r_9t7u0oudzybbrUD4xpZM-V1cmHURRLcIN-26Nw0MAJmeC2byk6bhVY5bQ6LakYXbfCwocDqab_hAnaazitd5MDc6fjHl6_QqOZkRhUKYkPFdBm4TzHlBTzUtChpp15bU9z2pvgfOS9KlHQoKcbQ6qo2N8nbM3kht8igrEpzh1Dp5VnkC-lLZoCfqiT3FPhaPxdcBcIIh2z2kElVp92OKURmab-GA3TZk8nEIY-XpketYMlpRi8Rd0sD1Bi3P1SLD2nnslLl6QCzi8Y-z3lmpBSApChgRgGwoVcO2egRl3aOr05_wc0hj5bF4LLwHEqWpjpGG9SZhLU-d8jtFuTLlgRBzFkchw6JV-C_0tTVkrI4tLLoAuaqMIE6N-1A-Xvv0-3pG_tw9989eEgu7k5H--n-cLx3j1xiGM1kA7U3yKBZHJv75Lz61BT14kHnBih5f9Yj6CflpqTn |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V3NbtQwELZKQRUX_n8CBQwCqZeoifPnHBAqLSuqwmolitRb6tgTGmk3KZsU1BuPAK_D4_AkzDjJworCrQduUexYdjIz_mJ__oaxpyFiIElCt0EAgRvGIbg5ogI3F0pp44MXKmWTTSTjsTw4SCcr7PtwFoZolUNMtIHa1JrWyDcR-pIKTxD7m0VPi5jsjF4cf3QpgxTttA7pNDoT2YPTz_j71jzf3cFv_UyI0av97ddun2HA1RFJU8rUGCPCCFIQhYjI1wsdQW4gVhqMJ7A8jFWkwTOJARyWSGOZ5CbJPfBkEWC7F9jFhETLLW1wMswCMQm728OYEUYcxEW9qhGxiHTb2CTM6dJcaFMGnIVz_6Rr_g6j7Tw4uvo_v8Fr7EqPvvlW5y7X2QpUN9ja255fcJN92-IzaNEvpnRYm6tesYXXBW-PynrK5x2lGDhifT4sw2A9w2e1KQvE83z848tX7FR7OuWaZLKxYb6g83NKhIEXDS8r3mvaNpwWwzk9o2ZlRUIPFSdmrakbuMXen8sLuc1Wq7qCu4wrr8hjXypfCUDUqtPC0xiB_UKGOpAgHbYxmE-me0V3SiwyzYY_O7Q0u1-ZOuzJoupxJ2NyVqWXZIOLCqQ8bm_U8w9ZH8gy7ZmAco4mfliEOSgl0ariQIBGI8dROWx9sL6sD4dN9sv0HPZ4UYyBjHanVAX1CdUh9UkhReiwO53BL3oSBEkokiRyWLLkCktdXS6pyiMrli5xBotSbHPDOs3fR59t77-zF_f-PYJHbA3dJnuzO967zy4LojhZ9vY6W23nJ_CAXdKf2rKZP7TxgLPD83afn87OrCY |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+metabolomic+analysis+of+thiol+response+for+standard+and+modified+N+%E2%80%90acetyl+cysteine+treatment+regimens+in+patients+with+acetaminophen+overdose&rft.jtitle=Clinical+and+translational+science&rft.au=Dear%2C+James+W&rft.au=Ng%2C+Mei+Li&rft.au=Bateman%2C+D.+Nicholas&rft.au=Leroy+Sivappiragasam%2C+Pakkiri&rft.date=2021-07-01&rft.issn=1752-8054&rft.eissn=1752-8062&rft.volume=14&rft.issue=4&rft.spage=1476&rft.epage=1489&rft_id=info:doi/10.1111%2Fcts.13009&rft.externalDBID=n%2Fa&rft.externalDocID=10_1111_cts_13009 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1752-8054&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1752-8054&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1752-8054&client=summon |