mRNA methylation in cell senescence

Cellular senescence, a developmental program central to normal aging and aging pathologies, is robustly regulated at the post‐transcriptional level. This regulation involves the interaction of RNA‐binding proteins and noncoding RNAs with senescence‐associated messenger RNAs (mRNAs). There is increas...

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Bibliographic Details
Published in:Wiley interdisciplinary reviews. RNA Vol. 10; no. 6; pp. e1547 - n/a
Main Authors: Casella, Gabriel, Tsitsipatis, Dimitrios, Abdelmohsen, Kotb, Gorospe, Myriam
Format: Journal Article
Language:English
Published: Hoboken, USA John Wiley & Sons, Inc 01.11.2019
Wiley Subscription Services, Inc
Subjects:
5‐methylcytosine
Aging
Cellular Senescence
Gene expression
Gene mapping
Gene regulation
Humans
Localization
Mass spectroscopy
Methylation
mRNA modifications
N6-methyladenosine
Nucleotides
RNA editing
RNA modification
RNA processing
RNA transport
RNA, Messenger - metabolism
RNA-Binding Proteins - metabolism
Senescence
Transcription
mRNA modifications
senescence
5-methylcytosine
N6-methyladenosine
aging
ISSN:1757-7004, 1757-7012, 1757-7012
Online Access:Get full text
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Summary:Cellular senescence, a developmental program central to normal aging and aging pathologies, is robustly regulated at the post‐transcriptional level. This regulation involves the interaction of RNA‐binding proteins and noncoding RNAs with senescence‐associated messenger RNAs (mRNAs). There is increasing evidence that these associations are modulated by chemical modifications of specific mRNA nucleotides which can enhance or reduce the binding of regulatory factors. Recent technological advances in mass spectrometry, next‐generation sequencing, and genome mapping have improved markedly the detection of mRNA modifications. Given the rising interest in the epitranscriptomic control of gene expression in aging, we discuss our incipient understanding of the chemical mRNA modifications, specifically m6A and m5C, that influence cellular senescence. This article is categorized under: RNA Export and Localization > RNA Localization RNA Processing > RNA Editing and Modification Main regulatory modifications reported in mRNAs encoding senescence‐associated proteins, m6A and m5C. Each modification can promote (green) or repress (purple) protein expression from the respective mRNAs.
Bibliography:Funding information
National Institute on Aging, NIH, Grant/Award Number: AG000393‐11
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Gabriel Casella and Dimitrios Tsitsipatis contributed equally to this study.
ISSN:1757-7004
1757-7012
1757-7012
DOI:10.1002/wrna.1547