Small-Molecule Stabilization of Protein-Protein Interactions: An Underestimated Concept in Drug Discovery?

The modulation of protein–protein interactions (PPIs) has been recognized as one of the most challenging tasks in drug discovery. While their systematic development has long been considered as intractable, this view has changed over the last years, with the first drug candidates undergoing clinical...

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Bibliographic Details
Published in:	Angewandte Chemie International Edition Vol. 51; no. 9; pp. 2012 - 2018
Main Authors:	Thiel, Philipp, Kaiser, Markus, Ottmann, Christian
Format:	Journal Article
Language:	English
Published:	Weinheim WILEY-VCH Verlag 27.02.2012 WILEY‐VCH Verlag Wiley Subscription Services, Inc
Edition:	International ed. in English
Subjects:	Animals Biological Products - chemistry Biological Products - pharmacology Construction drug design Drug Discovery - methods Drugs Humans Inhibitors Medical research Models, Molecular Modulation Modulators Pharmaceutical industry Protein Binding - drug effects Protein Interaction Mapping protein-protein interaction Proteins Proteins - chemistry Proteins - metabolism Recognition Small Molecule Libraries - chemistry Small Molecule Libraries - pharmacology small-molecule drugs Stabilization Strategy Tasks
ISSN:	1433-7851, 1521-3773, 1521-3773
Online Access:	Get full text
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