Circulating tumor DNA quantity is related to tumor volume and both predict survival in metastatic pancreatic ductal adenocarcinoma

Circulating tumor DNA (ctDNA) is assumed to reflect tumor burden and has been suggested as a tool for prognostication and follow‐up in patients with metastatic pancreatic ductal adenocarcinoma (mPDAC). However, the prognostic value of ctDNA and its relation with tumor burden has yet to be substantia...

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Bibliographic Details
Published in:	International journal of cancer Vol. 146; no. 5; pp. 1445 - 1456
Main Authors:	Strijker, Marin, Soer, Eline C., Pastena, Matteo, Creemers, Aafke, Balduzzi, Alberto, Beagan, Jamie J., Busch, Olivier R., Delden, Otto M., Halfwerk, Hans, Hooft, Jeanin E., Lienden, Krijn P., Marchegiani, Giovanni, Meijer, Sybren L., Noesel, Carel J., Reinten, Roy J., Roos, Eva, Schokker, Sandor, Verheij, Joanne, Vijver, Marc J., Waasdorp, Cynthia, Wilmink, Johanna W., Ylstra, Bauke, Besselink, Marc G., Bijlsma, Maarten F., Dijk, Frederike, Laarhoven, Hanneke W.
Format:	Journal Article
Language:	English
Published:	Hoboken, USA John Wiley & Sons, Inc 01.03.2020 Wiley Subscription Services, Inc
Subjects:	Adenocarcinoma Aged Biomarkers, Tumor - blood Biomarkers, Tumor - isolation & purification Cancer Carcinoma, Pancreatic Ductal - blood Carcinoma, Pancreatic Ductal - mortality Carcinoma, Pancreatic Ductal - secondary circulating tumor DNA Circulating Tumor DNA - blood Circulating Tumor DNA - isolation & purification Deoxyribonucleic acid DNA Female Follow-Up Studies Gene frequency High-Throughput Nucleotide Sequencing Humans KRAS Liver Liver Neoplasms - blood Liver Neoplasms - mortality Liver Neoplasms - secondary Male Medical research Metastases Metastasis Middle Aged Pancreas Pancreatic cancer Pancreatic Neoplasms - blood Pancreatic Neoplasms - mortality Pancreatic Neoplasms - pathology Prognosis Prospective Studies Retrospective Studies Tumor Burden Tumor Markers and Signatures tumor volume pancreatic cancer KRAS tumor volume prognosis circulating tumor DNA
ISSN:	0020-7136, 1097-0215, 1097-0215
Online Access:	Get full text
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