Deep gray matter volume loss drives disability worsening in multiple sclerosis

Objective Gray matter (GM) atrophy occurs in all multiple sclerosis (MS) phenotypes. We investigated whether there is a spatiotemporal pattern of GM atrophy that is associated with faster disability accumulation in MS. Methods We analyzed 3,604 brain high‐resolution T1‐weighted magnetic resonance im...

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Bibliographic Details
Published in:	Annals of neurology Vol. 83; no. 2; pp. 210 - 222
Main Authors:	Eshaghi, Arman, Prados, Ferran, Brownlee, Wallace J., Altmann, Daniel R., Tur, Carmen, Cardoso, M. Jorge, De Angelis, Floriana, van de Pavert, Steven H., Cawley, Niamh, De Stefano, Nicola, Stromillo, M. Laura, Battaglini, Marco, Ruggieri, Serena, Gasperini, Claudio, Filippi, Massimo, Rocca, Maria A., Rovira, Alex, Sastre‐Garriga, Jaume, Vrenken, Hugo, Leurs, Cyra E., Killestein, Joep, Pirpamer, Lukas, Enzinger, Christian, Ourselin, Sebastien, Wheeler‐Kingshott, Claudia A.M. Gandini, Chard, Declan, Thompson, Alan J., Alexander, Daniel C., Barkhof, Frederik, Ciccarelli, Olga
Format:	Journal Article
Language:	English
Published:	United States Wiley Subscription Services, Inc 01.02.2018 John Wiley and Sons Inc
Subjects:	Accumulation Adult Atrophy Atrophy - pathology Brain Brain - diagnostic imaging Brain - pathology Brain stem Cerebellum Confidence intervals Correlation analysis Cortex Disability Evaluation Disease Progression Female Gray Matter - diagnostic imaging Gray Matter - pathology Humans Image Interpretation, Computer-Assisted Longitudinal Studies Magnetic resonance imaging Magnetic Resonance Imaging - methods Male Middle Aged Multiple sclerosis Multiple Sclerosis - diagnostic imaging Multiple Sclerosis - pathology Neuroimaging Neuroimaging - methods Patients Regional analysis Regional development Retrospective Studies Standard deviation Substantia alba Substantia grisea Therapeutic applications
ISSN:	0364-5134, 1531-8249, 1531-8249
Online Access:	Get full text
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