Long non‐coding RNAs in development and disease: conservation to mechanisms

Our genomes contain the blueprint of what makes us human and many indications as to why we develop disease. Until the last 10 years, most studies had focussed on protein‐coding genes, more specifically DNA sequences coding for proteins. However, this represents less than 5% of our genomes. The other...

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Bibliographic Details
Published in:	The Journal of pathology Vol. 250; no. 5; pp. 480 - 495
Main Authors:	Tsagakis, Ioannis, Douka, Katerina, Birds, Isabel, Aspden, Julie L
Format:	Journal Article
Language:	English
Published:	Chichester, UK John Wiley & Sons, Ltd 01.04.2020 Wiley Subscription Services, Inc
Subjects:	Animals anti‐sense lncRNAs Base Sequence - genetics cancer Cell Nucleus - genetics conservation Cytoplasm Cytoplasm - metabolism development diabetes Evolutionary conservation Genomes Humans Invited Review Invited Reviews long intergenic non‐coding RNA long non‐coding RNA neurodegenerative disease Neurodegenerative Diseases - genetics Non-coding RNA Nucleotide sequence Proteins - genetics RNA, Long Noncoding - genetics stem cells translation United Kingdom X chromosome inactivation United Kingdom long intergenic non-coding RNA stem cells conservation development anti-sense lncRNAs neurodegenerative disease X chromosome inactivation translation cancer long non-coding RNA diabetes
ISSN:	0022-3417, 1096-9896, 1096-9896
Online Access:	Get full text
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