Long non‐coding RNAs in development and disease: conservation to mechanisms

Our genomes contain the blueprint of what makes us human and many indications as to why we develop disease. Until the last 10 years, most studies had focussed on protein‐coding genes, more specifically DNA sequences coding for proteins. However, this represents less than 5% of our genomes. The other...

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Vydáno v:	The Journal of pathology Ročník 250; číslo 5; s. 480 - 495
Hlavní autoři:	Tsagakis, Ioannis, Douka, Katerina, Birds, Isabel, Aspden, Julie L
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Chichester, UK John Wiley & Sons, Ltd 01.04.2020 Wiley Subscription Services, Inc
Témata:	Animals anti‐sense lncRNAs Base Sequence - genetics cancer Cell Nucleus - genetics conservation Cytoplasm Cytoplasm - metabolism development diabetes Evolutionary conservation Genomes Humans Invited Review Invited Reviews long intergenic non‐coding RNA long non‐coding RNA neurodegenerative disease Neurodegenerative Diseases - genetics Non-coding RNA Nucleotide sequence Proteins - genetics RNA, Long Noncoding - genetics stem cells translation United Kingdom X chromosome inactivation United Kingdom long intergenic non-coding RNA stem cells conservation development anti-sense lncRNAs neurodegenerative disease X chromosome inactivation translation cancer long non-coding RNA diabetes
ISSN:	0022-3417, 1096-9896, 1096-9896
On-line přístup:	Získat plný text
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