Flipping the Metabolic Switch: Understanding and Applying the Health Benefits of Fasting
Objective Intermittent fasting (IF) is a term used to describe a variety of eating patterns in which no or few calories are consumed for time periods that can range from 12 hours to several days, on a recurring basis. This review is focused on the physiological responses of major organ systems, incl...
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| Vydáno v: | Obesity (Silver Spring, Md.) Ročník 26; číslo 2; s. 254 - 268 |
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| Hlavní autoři: | , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
United States
Blackwell Publishing Ltd
01.02.2018
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| Témata: | |
| ISSN: | 1930-7381, 1930-739X, 1930-739X |
| On-line přístup: | Získat plný text |
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| Abstract | Objective
Intermittent fasting (IF) is a term used to describe a variety of eating patterns in which no or few calories are consumed for time periods that can range from 12 hours to several days, on a recurring basis. This review is focused on the physiological responses of major organ systems, including the musculoskeletal system, to the onset of the metabolic switch: the point of negative energy balance at which liver glycogen stores are depleted and fatty acids are mobilized (typically beyond 12 hours after cessation of food intake).
Results and Conclusions
Emerging findings suggest that the metabolic switch from glucose to fatty acid‐derived ketones represents an evolutionarily conserved trigger point that shifts metabolism from lipid/cholesterol synthesis and fat storage to mobilization of fat through fatty acid oxidation and fatty acid‐derived ketones, which serve to preserve muscle mass and function. Thus, IF regimens that induce the metabolic switch have the potential to improve body composition in overweight individuals. Moreover, IF regimens also induce the coordinated activation of signaling pathways that optimize physiological function, enhance performance, and slow aging and disease processes. Future randomized controlled IF trials should use biomarkers of the metabolic switch (e.g., plasma ketone levels) as a measure of compliance and of the magnitude of negative energy balance during the fasting period. |
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| AbstractList | Intermittent fasting (IF) is a term used to describe a variety of eating patterns in which no or few calories are consumed for time periods that can range from 12 hours to several days, on a recurring basis. Here we focus on the physiological responses of major organ systems, including the musculoskeletal system, to the onset of the metabolic switch – the point of negative energy balance at which liver glycogen stores are depleted and fatty acids are mobilized (typically beyond 12 hours after cessation of food intake). Emerging findings suggest the metabolic switch from glucose to fatty acid-derived ketones represents an evolutionarily conserved trigger point that shifts metabolism from lipid/cholesterol synthesis and fat storage to mobilization of fat through fatty acid oxidation and fatty-acid derived ketones, which serve to preserve muscle mass and function. Thus, IF regimens that induce the metabolic switch have the potential to improve body composition in overweight individuals. Moreover, IF regimens also induce the coordinated activation of signaling pathways that optimize physiological function, enhance performance, and slow aging and disease processes. Future randomized controlled IF trials should use biomarkers of the metabolic switch (e.g., plasma ketone levels) as a measure of compliance and the magnitude of negative energy balance during the fasting period. Intermittent fasting (IF) is a term used to describe a variety of eating patterns in which no or few calories are consumed for time periods that can range from 12 hours to several days, on a recurring basis. This review is focused on the physiological responses of major organ systems, including the musculoskeletal system, to the onset of the metabolic switch: the point of negative energy balance at which liver glycogen stores are depleted and fatty acids are mobilized (typically beyond 12 hours after cessation of food intake). Emerging findings suggest that the metabolic switch from glucose to fatty acid-derived ketones represents an evolutionarily conserved trigger point that shifts metabolism from lipid/cholesterol synthesis and fat storage to mobilization of fat through fatty acid oxidation and fatty acid-derived ketones, which serve to preserve muscle mass and function. Thus, IF regimens that induce the metabolic switch have the potential to improve body composition in overweight individuals. Moreover, IF regimens also induce the coordinated activation of signaling pathways that optimize physiological function, enhance performance, and slow aging and disease processes. Future randomized controlled IF trials should use biomarkers of the metabolic switch (e.g., plasma ketone levels) as a measure of compliance and of the magnitude of negative energy balance during the fasting period. Intermittent fasting (IF) is a term used to describe a variety of eating patterns in which no or few calories are consumed for time periods that can range from 12 hours to several days, on a recurring basis. This review is focused on the physiological responses of major organ systems, including the musculoskeletal system, to the onset of the metabolic switch: the point of negative energy balance at which liver glycogen stores are depleted and fatty acids are mobilized (typically beyond 12 hours after cessation of food intake).OBJECTIVEIntermittent fasting (IF) is a term used to describe a variety of eating patterns in which no or few calories are consumed for time periods that can range from 12 hours to several days, on a recurring basis. This review is focused on the physiological responses of major organ systems, including the musculoskeletal system, to the onset of the metabolic switch: the point of negative energy balance at which liver glycogen stores are depleted and fatty acids are mobilized (typically beyond 12 hours after cessation of food intake).Emerging findings suggest that the metabolic switch from glucose to fatty acid-derived ketones represents an evolutionarily conserved trigger point that shifts metabolism from lipid/cholesterol synthesis and fat storage to mobilization of fat through fatty acid oxidation and fatty acid-derived ketones, which serve to preserve muscle mass and function. Thus, IF regimens that induce the metabolic switch have the potential to improve body composition in overweight individuals. Moreover, IF regimens also induce the coordinated activation of signaling pathways that optimize physiological function, enhance performance, and slow aging and disease processes. Future randomized controlled IF trials should use biomarkers of the metabolic switch (e.g., plasma ketone levels) as a measure of compliance and of the magnitude of negative energy balance during the fasting period.RESULTS AND CONCLUSIONSEmerging findings suggest that the metabolic switch from glucose to fatty acid-derived ketones represents an evolutionarily conserved trigger point that shifts metabolism from lipid/cholesterol synthesis and fat storage to mobilization of fat through fatty acid oxidation and fatty acid-derived ketones, which serve to preserve muscle mass and function. Thus, IF regimens that induce the metabolic switch have the potential to improve body composition in overweight individuals. Moreover, IF regimens also induce the coordinated activation of signaling pathways that optimize physiological function, enhance performance, and slow aging and disease processes. Future randomized controlled IF trials should use biomarkers of the metabolic switch (e.g., plasma ketone levels) as a measure of compliance and of the magnitude of negative energy balance during the fasting period. Objective Intermittent fasting (IF) is a term used to describe a variety of eating patterns in which no or few calories are consumed for time periods that can range from 12 hours to several days, on a recurring basis. This review is focused on the physiological responses of major organ systems, including the musculoskeletal system, to the onset of the metabolic switch: the point of negative energy balance at which liver glycogen stores are depleted and fatty acids are mobilized (typically beyond 12 hours after cessation of food intake). Results and Conclusions Emerging findings suggest that the metabolic switch from glucose to fatty acid‐derived ketones represents an evolutionarily conserved trigger point that shifts metabolism from lipid/cholesterol synthesis and fat storage to mobilization of fat through fatty acid oxidation and fatty acid‐derived ketones, which serve to preserve muscle mass and function. Thus, IF regimens that induce the metabolic switch have the potential to improve body composition in overweight individuals. Moreover, IF regimens also induce the coordinated activation of signaling pathways that optimize physiological function, enhance performance, and slow aging and disease processes. Future randomized controlled IF trials should use biomarkers of the metabolic switch (e.g., plasma ketone levels) as a measure of compliance and of the magnitude of negative energy balance during the fasting period. Intermittent fasting (IF) is a term used to describe a variety of eating patterns in which no or few calories are consumed for time periods that can range from 12 hours to several days, on a recurring basis. This review is focused on the physiological responses of major organ systems, including the musculoskeletal system, to the onset of the metabolic switch: the point of negative energy balance at which liver glycogen stores are depleted and fatty acids are mobilized (typically beyond 12 hours after cessation of food intake). Emerging findings suggest that the metabolic switch from glucose to fatty acid-derived ketones represents an evolutionarily conserved trigger point that shifts metabolism from lipid/cholesterol synthesis and fat storage to mobilization of fat through fatty acid oxidation and fatty acid-derived ketones, which serve to preserve muscle mass and function. Thus, IF regimens that induce the metabolic switch have the potential to improve body composition in overweight individuals. Moreover, IF regimens also induce the coordinated activation of signaling pathways that optimize physiological function, enhance performance, and slow aging and disease processes. Future randomized controlled IF trials should use biomarkers of the metabolic switch (e.g., plasma ketone levels) as a measure of compliance and of the magnitude of negative energy balance during the fasting period. |
| Author | Anton, Stephen D. Mainous, Arch G. Leeuwenburgh, Christiaan Mattson, Mark P. Moehl, Keelin Lee, Stephanie A. Donahoo, William T. Marosi, Krisztina |
| AuthorAffiliation | 4 Department of Health Services Research, Management and Policy; Department of Community Health and Family Medicine, University of Florida, Gainesville, FL 32610 5 Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205 3 Division of Endocrinology, Diabetes and Metabolism, University of Florida College of Medicine, Gainesville, FL 32610 2 Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224 1 Department of Aging and Geriatric Research, Institute on Aging, Department of Clinical and Health Psychology, University of Florida, Gainesville, FL 32610 |
| AuthorAffiliation_xml | – name: 1 Department of Aging and Geriatric Research, Institute on Aging, Department of Clinical and Health Psychology, University of Florida, Gainesville, FL 32610 – name: 2 Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224 – name: 5 Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205 – name: 4 Department of Health Services Research, Management and Policy; Department of Community Health and Family Medicine, University of Florida, Gainesville, FL 32610 – name: 3 Division of Endocrinology, Diabetes and Metabolism, University of Florida College of Medicine, Gainesville, FL 32610 |
| Author_xml | – sequence: 1 givenname: Stephen D. orcidid: 0000-0001-5020-5280 surname: Anton fullname: Anton, Stephen D. email: santon@ufl.edu organization: University of Florida – sequence: 2 givenname: Keelin surname: Moehl fullname: Moehl, Keelin organization: Laboratory of Neurosciences, National Institute on Aging Intramural Research Program – sequence: 3 givenname: William T. surname: Donahoo fullname: Donahoo, William T. organization: University of Florida – sequence: 4 givenname: Krisztina surname: Marosi fullname: Marosi, Krisztina organization: Laboratory of Neurosciences, National Institute on Aging Intramural Research Program – sequence: 5 givenname: Stephanie A. surname: Lee fullname: Lee, Stephanie A. organization: University of Florida – sequence: 6 givenname: Arch G. surname: Mainous fullname: Mainous, Arch G. organization: University of Florida – sequence: 7 givenname: Christiaan surname: Leeuwenburgh fullname: Leeuwenburgh, Christiaan organization: University of Florida – sequence: 8 givenname: Mark P. surname: Mattson fullname: Mattson, Mark P. email: mark.mattson@nih.gov organization: Johns Hopkins University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29086496$$D View this record in MEDLINE/PubMed |
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| Notes | Drs. Anton and Leeuwenburgh are supported by the University of Florida's Claude D. Pepper Older Americans Independence Center (NIH/NIA P30AG028740). Drs. Moehl, Marosi, and Mattson are supported by the National Institute on Aging Intramural Research Program. The authors declared no conflict of interest. Disclosure Funding agencies ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 |
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| Publisher | Blackwell Publishing Ltd |
| Publisher_xml | – name: Blackwell Publishing Ltd |
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Intermittent fasting (IF) is a term used to describe a variety of eating patterns in which no or few calories are consumed for time periods that can... Intermittent fasting (IF) is a term used to describe a variety of eating patterns in which no or few calories are consumed for time periods that can range from... |
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| SubjectTerms | Body composition Brain Clinical trials Diabetes Eating - physiology Energy Energy Intake - physiology Exercise Fasting Fasting - metabolism Fasting - physiology Fatty acids Feeding Behavior - physiology Glucose Humans Insulin resistance Lipids Metabolic syndrome Obesity Physical fitness Physiology Risk factors Weight control |
| Title | Flipping the Metabolic Switch: Understanding and Applying the Health Benefits of Fasting |
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