Co‐occurrence of immune‐mediated conditions and endometriosis among adolescents and adult women

Problem Associations between immune dysfunction conditions (eg, systemic lupus erythematous, rheumatoid arthritis) and endometriosis have been observed in adult women, but not assessed among a younger population. We investigated the association between immune‐mediated conditions and endometriosis am...

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Vydané v:American journal of reproductive immunology (1989) Ročník 86; číslo 1; s. e13404 - n/a
Hlavní autori: Shafrir, Amy L, Palmor, Marissa C., Fourquet, Jessica, DiVasta, Amy D., Farland, Leslie V., Vitonis, Allison F., Harris, Holly R, Laufer, Marc R., Cramer, Daniel W., Terry, Kathryn L., Missmer, Stacey A.
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Denmark Wiley Subscription Services, Inc 01.07.2021
Predmet:
Adolescent
Adolescents
Adult
Age Factors
allergies
Arthritis, Rheumatoid - epidemiology
Asthma
Atopy
autoimmune Diseases
Child
Child, Preschool
Chronic fatigue syndrome
Chronic infection
Chronic pain
Comorbidity
Cross-Sectional Studies
Eczema
Endocrine disorders
Endometriosis
Endometriosis - epidemiology
epidemiology
Fatigue
Female
Fibromyalgia
Humans
Inflammatory diseases
Mastocytosis, Systemic - epidemiology
Middle Aged
Mononucleosis
Rheumatoid arthritis
Systemic lupus erythematosus
Teenagers
United States - epidemiology
Womens health
Young Adult
United States
allergies
endometriosis
epidemiology
asthma
autoimmune Diseases
ISSN:1046-7408, 1600-0897, 1600-0897
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Shrnutí:Problem Associations between immune dysfunction conditions (eg, systemic lupus erythematous, rheumatoid arthritis) and endometriosis have been observed in adult women, but not assessed among a younger population. We investigated the association between immune‐mediated conditions and endometriosis among young women. Method of Study This cross‐sectional analysis in the Women's Health Study: From Adolescence to Adulthood included 551 participants with surgically diagnosed endometriosis (median age=19) and 652 controls without endometriosis (median age=24). Participants completed an expanded Endometriosis Phenome and Biobanking Harmonization Project questionnaire. We used logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (CIs) to investigate the associations between autoimmune/inflammatory, atopic, chronic pain/fatigue, and endocrine disorders with endometriosis, adjusting for confounders. Results Participants with any autoimmune and/or inflammatory condition had an increased odds of co‐occurring endometriosis (OR: 1.87; CI: 0.92–3.80), as did participants with allergies (OR: 1.76; CI: 1.32–2.36), asthma (OR: 1.35; CI: 0.97–1.88), chronic fatigue syndrome and/or fibromyalgia (OR: 5.81; CI: 1.89–17.9), or previous mononucleosis (OR: 1.75; CI: 1.14–2.68). Odds of endometriosis were lower among participants with eczema (OR: 0.68; CI: 0.44–1.04). We observed a positive trend between the number of immune‐mediated conditions and the odds of endometriosis (p‐trend=0.0002). Endocrine disorders were not associated with endometriosis. Conclusions Among this population of adolescents and adult women, endometriosis was more likely among participants with autoimmune and/or inflammatory diseases, allergies, asthma, previous mononucleosis infection, and chronic fatigue and/or fibromyalgia. We observed that an increasing number of immune‐mediated conditions were positively associated with endometriosis risk. It is important for clinicians who care for adolescents and women with these conditions to consider endometriosis as a comorbidity.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1046-7408
1600-0897
1600-0897
DOI:10.1111/aji.13404