Impact of treatment delay on survival of oral/oropharyngeal cancers: Results of a nationwide screening program

Background To assess the impact of treatment delay on survival of oral/oropharyngeal cancer (OSCC). Methods We followed 5743 OSCCs between 2004 and 2009 from a population‐based screening program and ascertained death until the end of 2012. Results The hazard ratios (HRs) of mortality from OSCC were...

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Published in:Head & neck Vol. 43; no. 2; pp. 473 - 484
Main Authors: Su, William Wang‐Yu, Lee, Yi‐Huah, Yen, Amy Ming‐Fang, Chen, Sam Li‐Sheng, Hsu, Chen‐Yang, Chiu, Sherry Yueh‐Hsia, Fann, Jean Ching‐Yuan, Lee, Yi‐Chia, Chiu, Han‐Mo, Hsiao, Shu‐Chun, Hsu, Tsui‐Hsia, Chen, Hsiu‐Hsi
Format: Journal Article
Language:English
Published: Hoboken, USA John Wiley & Sons, Inc 01.02.2021
Wiley Subscription Services, Inc
Subjects:
betel quid chewing
cigarette smoking
Head & neck cancer
Head and neck
Mortality
Oral cancer
oral/oropharyngeal cancer
Original
Oropharyngeal cancer
Palate
Survival
Throat cancer
treatment delay
cigarette smoking
betel quid chewing
treatment delay
oral/oropharyngeal cancer
survival
ISSN:1043-3074, 1097-0347, 1097-0347
Online Access:Get full text
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Summary:Background To assess the impact of treatment delay on survival of oral/oropharyngeal cancer (OSCC). Methods We followed 5743 OSCCs between 2004 and 2009 from a population‐based screening program and ascertained death until the end of 2012. Results The hazard ratios (HRs) of mortality from OSCC were 1.46 (1.30‐1.65) and 1.18 (1.04‐1.33) in univariable and multivariable analyses, respectively, for treatment delay longer than 6 weeks compared with that shorter than 3 weeks. The corresponding figures were 1.12 (1.01‐1.24) and 1.00 (0.91‐1.11) for treatment delay between 3 and 6 weeks. Advancing age (1.01), higher stage (stage II: 1.84, stage III: 2.97, stage IV: 6.33), cancer in tongue (1.37), or hard palate (1.63) had higher HR of mortality (P < .05). However, treatment at medical center had a lower mortality (0.83, 0.75‐0.91) than local/regional hospital. Conclusions Treatment delay longer than 6 weeks for OSCCs detected via a population‐based screening program had unfavorable survival.
Bibliography:William Wang‐Yu Su and Yi‐Huah Lee contributed equally to this study.
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Section Editor: Benjamin Judson
ISSN:1043-3074
1097-0347
1097-0347
DOI:10.1002/hed.26504