A probiotic modulates the microbiome and immunity in multiple sclerosis
Objective Effect of a probiotic on the gut microbiome and peripheral immune function in healthy controls and relapsing‐remitting multiple sclerosis (MS) patients. Methods MS patients (N = 9) and controls (N = 13) were orally administered a probiotic containing Lactobacillus, Bifidobacterium, and Str...
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| Vydáno v: | Annals of neurology Ročník 83; číslo 6; s. 1147 - 1161 |
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| Hlavní autoři: | , , , , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
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United States
Wiley Subscription Services, Inc
01.06.2018
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| Témata: | |
| ISSN: | 0364-5134, 1531-8249, 1531-8249 |
| On-line přístup: | Získat plný text |
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| Abstract | Objective
Effect of a probiotic on the gut microbiome and peripheral immune function in healthy controls and relapsing‐remitting multiple sclerosis (MS) patients.
Methods
MS patients (N = 9) and controls (N = 13) were orally administered a probiotic containing Lactobacillus, Bifidobacterium, and Streptococcus twice‐daily for two months. Blood and stool specimens were collected at baseline, after completion of the 2‐month treatment, and 3 months after discontinuation of therapy. Frozen peripheral blood mononuclear cells (PBMCs) were used for immune cell profiling. Stool samples were used for 16S rRNA profiling and metabolomics.
Results
Probiotic administration increased the abundance of several taxa known to be depleted in MS such as Lactobacillus. We found that probiotic use decreased the abundance of taxa previously associated with dysbiosis in MS, including Akkermansia and Blautia. Predictive metagenomic analysis revealed a decrease in the abundance of several KEGG (Kyoto Encyclopedia of Genes and Genomes) pathways associated with altered gut microbiota function in MS patients, such as methane metabolism, following probiotic supplementation. At the immune level, probiotic administration induced an anti‐inflammatory peripheral immune response characterized by decreased frequency of inflammatory monocytes, decreased mean fluorescence intensity (MFI) of CD80 on classical monocytes, as well as decreased human leukocyte antigen (HLA) D related MFI on dendritic cells. Probiotic administration was also associated with decreased expression of MS risk allele HLA‐DQA1 in controls. Probiotic‐induced increase in abundance of Lactobacillus and Bifidobacterium was associated with decreased expression of MS risk allele HLA.DPB1 in controls.
Interpretation
Our results suggest that probiotics could have a synergistic effect with current MS therapies. Ann Neurol 2018 |
|---|---|
| AbstractList | ObjectiveEffect of a probiotic on the gut microbiome and peripheral immune function in healthy controls and relapsing‐remitting multiple sclerosis (MS) patients.MethodsMS patients (N = 9) and controls (N = 13) were orally administered a probiotic containing Lactobacillus, Bifidobacterium, and Streptococcus twice‐daily for two months. Blood and stool specimens were collected at baseline, after completion of the 2‐month treatment, and 3 months after discontinuation of therapy. Frozen peripheral blood mononuclear cells (PBMCs) were used for immune cell profiling. Stool samples were used for 16S rRNA profiling and metabolomics.ResultsProbiotic administration increased the abundance of several taxa known to be depleted in MS such as Lactobacillus. We found that probiotic use decreased the abundance of taxa previously associated with dysbiosis in MS, including Akkermansia and Blautia. Predictive metagenomic analysis revealed a decrease in the abundance of several KEGG (Kyoto Encyclopedia of Genes and Genomes) pathways associated with altered gut microbiota function in MS patients, such as methane metabolism, following probiotic supplementation. At the immune level, probiotic administration induced an anti‐inflammatory peripheral immune response characterized by decreased frequency of inflammatory monocytes, decreased mean fluorescence intensity (MFI) of CD80 on classical monocytes, as well as decreased human leukocyte antigen (HLA) D related MFI on dendritic cells. Probiotic administration was also associated with decreased expression of MS risk allele HLA‐DQA1 in controls. Probiotic‐induced increase in abundance of Lactobacillus and Bifidobacterium was associated with decreased expression of MS risk allele HLA.DPB1 in controls.InterpretationOur results suggest that probiotics could have a synergistic effect with current MS therapies. Ann Neurol 2018 Objective Effect of a probiotic on the gut microbiome and peripheral immune function in healthy controls and relapsing‐remitting multiple sclerosis (MS) patients. Methods MS patients (N = 9) and controls (N = 13) were orally administered a probiotic containing Lactobacillus, Bifidobacterium, and Streptococcus twice‐daily for two months. Blood and stool specimens were collected at baseline, after completion of the 2‐month treatment, and 3 months after discontinuation of therapy. Frozen peripheral blood mononuclear cells (PBMCs) were used for immune cell profiling. Stool samples were used for 16S rRNA profiling and metabolomics. Results Probiotic administration increased the abundance of several taxa known to be depleted in MS such as Lactobacillus. We found that probiotic use decreased the abundance of taxa previously associated with dysbiosis in MS, including Akkermansia and Blautia. Predictive metagenomic analysis revealed a decrease in the abundance of several KEGG (Kyoto Encyclopedia of Genes and Genomes) pathways associated with altered gut microbiota function in MS patients, such as methane metabolism, following probiotic supplementation. At the immune level, probiotic administration induced an anti‐inflammatory peripheral immune response characterized by decreased frequency of inflammatory monocytes, decreased mean fluorescence intensity (MFI) of CD80 on classical monocytes, as well as decreased human leukocyte antigen (HLA) D related MFI on dendritic cells. Probiotic administration was also associated with decreased expression of MS risk allele HLA‐DQA1 in controls. Probiotic‐induced increase in abundance of Lactobacillus and Bifidobacterium was associated with decreased expression of MS risk allele HLA.DPB1 in controls. Interpretation Our results suggest that probiotics could have a synergistic effect with current MS therapies. Ann Neurol 2018 Effect of a probiotic on the gut microbiome and peripheral immune function in healthy controls and relapsing-remitting multiple sclerosis (MS) patients.OBJECTIVEEffect of a probiotic on the gut microbiome and peripheral immune function in healthy controls and relapsing-remitting multiple sclerosis (MS) patients.MS patients (N = 9) and controls (N = 13) were orally administered a probiotic containing Lactobacillus, Bifidobacterium, and Streptococcus twice-daily for two months. Blood and stool specimens were collected at baseline, after completion of the 2-month treatment, and 3 months after discontinuation of therapy. Frozen peripheral blood mononuclear cells (PBMCs) were used for immune cell profiling. Stool samples were used for 16S rRNA profiling and metabolomics.METHODSMS patients (N = 9) and controls (N = 13) were orally administered a probiotic containing Lactobacillus, Bifidobacterium, and Streptococcus twice-daily for two months. Blood and stool specimens were collected at baseline, after completion of the 2-month treatment, and 3 months after discontinuation of therapy. Frozen peripheral blood mononuclear cells (PBMCs) were used for immune cell profiling. Stool samples were used for 16S rRNA profiling and metabolomics.Probiotic administration increased the abundance of several taxa known to be depleted in MS such as Lactobacillus. We found that probiotic use decreased the abundance of taxa previously associated with dysbiosis in MS, including Akkermansia and Blautia. Predictive metagenomic analysis revealed a decrease in the abundance of several KEGG (Kyoto Encyclopedia of Genes and Genomes) pathways associated with altered gut microbiota function in MS patients, such as methane metabolism, following probiotic supplementation. At the immune level, probiotic administration induced an anti-inflammatory peripheral immune response characterized by decreased frequency of inflammatory monocytes, decreased mean fluorescence intensity (MFI) of CD80 on classical monocytes, as well as decreased human leukocyte antigen (HLA) D related MFI on dendritic cells. Probiotic administration was also associated with decreased expression of MS risk allele HLA-DQA1 in controls. Probiotic-induced increase in abundance of Lactobacillus and Bifidobacterium was associated with decreased expression of MS risk allele HLA.DPB1 in controls.RESULTSProbiotic administration increased the abundance of several taxa known to be depleted in MS such as Lactobacillus. We found that probiotic use decreased the abundance of taxa previously associated with dysbiosis in MS, including Akkermansia and Blautia. Predictive metagenomic analysis revealed a decrease in the abundance of several KEGG (Kyoto Encyclopedia of Genes and Genomes) pathways associated with altered gut microbiota function in MS patients, such as methane metabolism, following probiotic supplementation. At the immune level, probiotic administration induced an anti-inflammatory peripheral immune response characterized by decreased frequency of inflammatory monocytes, decreased mean fluorescence intensity (MFI) of CD80 on classical monocytes, as well as decreased human leukocyte antigen (HLA) D related MFI on dendritic cells. Probiotic administration was also associated with decreased expression of MS risk allele HLA-DQA1 in controls. Probiotic-induced increase in abundance of Lactobacillus and Bifidobacterium was associated with decreased expression of MS risk allele HLA.DPB1 in controls.Our results suggest that probiotics could have a synergistic effect with current MS therapies. Ann Neurol 2018.INTERPRETATIONOur results suggest that probiotics could have a synergistic effect with current MS therapies. Ann Neurol 2018. Effect of a probiotic on the gut microbiome and peripheral immune function in healthy controls and relapsing-remitting multiple sclerosis (MS) patients. MS patients (N = 9) and controls (N = 13) were orally administered a probiotic containing Lactobacillus, Bifidobacterium, and Streptococcus twice-daily for two months. Blood and stool specimens were collected at baseline, after completion of the 2-month treatment, and 3 months after discontinuation of therapy. Frozen peripheral blood mononuclear cells (PBMCs) were used for immune cell profiling. Stool samples were used for 16S rRNA profiling and metabolomics. Probiotic administration increased the abundance of several taxa known to be depleted in MS such as Lactobacillus. We found that probiotic use decreased the abundance of taxa previously associated with dysbiosis in MS, including Akkermansia and Blautia. Predictive metagenomic analysis revealed a decrease in the abundance of several KEGG (Kyoto Encyclopedia of Genes and Genomes) pathways associated with altered gut microbiota function in MS patients, such as methane metabolism, following probiotic supplementation. At the immune level, probiotic administration induced an anti-inflammatory peripheral immune response characterized by decreased frequency of inflammatory monocytes, decreased mean fluorescence intensity (MFI) of CD80 on classical monocytes, as well as decreased human leukocyte antigen (HLA) D related MFI on dendritic cells. Probiotic administration was also associated with decreased expression of MS risk allele HLA-DQA1 in controls. Probiotic-induced increase in abundance of Lactobacillus and Bifidobacterium was associated with decreased expression of MS risk allele HLA.DPB1 in controls. Our results suggest that probiotics could have a synergistic effect with current MS therapies. Ann Neurol 2018. |
| Author | Glanz, Bonnie Gandhi, Roopali Tankou, Stephanie K. Tjon, Emily Laghi, Luca Cook, Sandra Cox, Laura M. Kivisäkk, Pia Pierre, Isabelle V. Stankiewicz, James Weiner, Howard L. Healy, Brian C. Hrishikesh, Lokhande Regev, Keren |
| AuthorAffiliation | 1 Ann Romney Center for Neurologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women’s Hospital, Department of Neurology, Harvard Medical School, Boston, Massachusetts 02115, USA 2 Evergrande Center for Immunologic Diseases 3 University of Bologna, Department of Agricultural and Food Sciences, Cesena 47521, Italy |
| AuthorAffiliation_xml | – name: 3 University of Bologna, Department of Agricultural and Food Sciences, Cesena 47521, Italy – name: 1 Ann Romney Center for Neurologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women’s Hospital, Department of Neurology, Harvard Medical School, Boston, Massachusetts 02115, USA – name: 2 Evergrande Center for Immunologic Diseases |
| Author_xml | – sequence: 1 givenname: Stephanie K. surname: Tankou fullname: Tankou, Stephanie K. email: stankou@bwh.harvard.edu organization: Evergrande Center for Immunologic Diseases – sequence: 2 givenname: Keren surname: Regev fullname: Regev, Keren organization: Ann Romney Center for Neurologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Department of Neurology, Harvard Medical School – sequence: 3 givenname: Brian C. surname: Healy fullname: Healy, Brian C. organization: Ann Romney Center for Neurologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Department of Neurology, Harvard Medical School – sequence: 4 givenname: Emily surname: Tjon fullname: Tjon, Emily organization: Evergrande Center for Immunologic Diseases – sequence: 5 givenname: Luca surname: Laghi fullname: Laghi, Luca organization: University of Bologna, Department of Agricultural and Food Sciences – sequence: 6 givenname: Laura M. surname: Cox fullname: Cox, Laura M. organization: Evergrande Center for Immunologic Diseases – sequence: 7 givenname: Pia surname: Kivisäkk fullname: Kivisäkk, Pia organization: Evergrande Center for Immunologic Diseases – sequence: 8 givenname: Isabelle V. surname: Pierre fullname: Pierre, Isabelle V. organization: Evergrande Center for Immunologic Diseases – sequence: 9 givenname: Lokhande surname: Hrishikesh fullname: Hrishikesh, Lokhande organization: Ann Romney Center for Neurologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Department of Neurology, Harvard Medical School – sequence: 10 givenname: Roopali surname: Gandhi fullname: Gandhi, Roopali organization: Evergrande Center for Immunologic Diseases – sequence: 11 givenname: Sandra surname: Cook fullname: Cook, Sandra organization: Ann Romney Center for Neurologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Department of Neurology, Harvard Medical School – sequence: 12 givenname: Bonnie surname: Glanz fullname: Glanz, Bonnie organization: Ann Romney Center for Neurologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Department of Neurology, Harvard Medical School – sequence: 13 givenname: James surname: Stankiewicz fullname: Stankiewicz, James organization: Ann Romney Center for Neurologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Department of Neurology, Harvard Medical School – sequence: 14 givenname: Howard L. surname: Weiner fullname: Weiner, Howard L. organization: Evergrande Center for Immunologic Diseases |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29679417$$D View this record in MEDLINE/PubMed |
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| Copyright | 2018 American Neurological Association 2018 American Neurological Association. |
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Effect of a probiotic on the gut microbiome and peripheral immune function in healthy controls and relapsing‐remitting multiple sclerosis (MS)... Effect of a probiotic on the gut microbiome and peripheral immune function in healthy controls and relapsing-remitting multiple sclerosis (MS) patients. MS... ObjectiveEffect of a probiotic on the gut microbiome and peripheral immune function in healthy controls and relapsing‐remitting multiple sclerosis (MS)... Effect of a probiotic on the gut microbiome and peripheral immune function in healthy controls and relapsing-remitting multiple sclerosis (MS)... |
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| SubjectTerms | Abundance Adult Alleles Bifidobacterium Bifidobacterium - genetics Bifidobacterium - immunology CD80 antigen Dendritic cells DQA1 protein Dysbacteriosis Encyclopedias Female Fluorescence Gastrointestinal Microbiome - physiology Genomes Histocompatibility antigen HLA Humans Immune response Immune system Immunity Inflammation Intestinal microflora Lactobacillus Lactobacillus - genetics Lactobacillus - immunology Leukocytes Leukocytes (mononuclear) Leukocytes, Mononuclear - metabolism Male Metabolism Metabolomics Microbiomes Microbiota Microbiota - genetics Microbiota - immunology Middle Aged Monocytes Multiple sclerosis Multiple Sclerosis - genetics Multiple Sclerosis - immunology Oral administration Patients Peripheral blood mononuclear cells Probiotics Probiotics - metabolism RNA, Ribosomal, 16S - genetics rRNA 16S Supplements Synergistic effect Young Adult |
| Title | A probiotic modulates the microbiome and immunity in multiple sclerosis |
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