Cholangiocyte senescence by way of N‐ras activation is a characteristic of primary sclerosing cholangitis

Primary sclerosing cholangitis (PSC) is an incurable cholangiopathy of unknown etiopathogenesis. Here we tested the hypothesis that cholangiocyte senescence is a pathophysiologically important phenotype in PSC. We assessed markers of cellular senescence and senescence‐associated secretory phenotype...

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Bibliographic Details
Published in:Hepatology (Baltimore, Md.) Vol. 59; no. 6; pp. 2263 - 2275
Main Authors: Tabibian, James H., O'Hara, Steven P., Splinter, Patrick L., Trussoni, Christy E., LaRusso, Nicholas F.
Format: Journal Article
Language:English
Published: United States Wolters Kluwer Health, Inc 01.06.2014
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ISSN:0270-9139, 1527-3350, 1527-3350
Online Access:Get full text
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