Global cerebrospinal fluid as a zero‐reference regularization for brain quantitative susceptibility mapping

Background and Purpose The objective ofthis study was to demonstrate a global cerebrospinal fluid (CSF) method for a consistent and automated zero referencing of brain quantitative susceptibility mapping (QSM). Methods Whole brain CSF mask was automatically segmented by thresholding the gradient ech...

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Veröffentlicht in:Journal of neuroimaging Jg. 32; H. 1; S. 141 - 147
Hauptverfasser: Dimov, Alexey V., Nguyen, Thanh D., Spincemaille, Pascal, Sweeney, Elizabeth M., Zinger, Nicole, Kovanlikaya, Ilhami, Kopell, Brian H., Gauthier, Susan A., Wang, Yi
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States Wiley Subscription Services, Inc 01.01.2022
Schlagworte:
Algorithms
artifact reduction
Brain
Brain - diagnostic imaging
Brain mapping
Brain Mapping - methods
Cerebrospinal fluid
Humans
Image Processing, Computer-Assisted - methods
Image quality
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Mapping
Movement disorders
Multiple sclerosis
Neurodegenerative diseases
Neuroimaging
Parkinson's disease
quantitative susceptibility mapping
Referencing
Regularization
Regularization methods
repeatability
Reproducibility
Susceptibility
Ventricle
zero referencing
repeatability
quantitative susceptibility mapping
zero referencing
artifact reduction
ISSN:1051-2284, 1552-6569, 1552-6569
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Zusammenfassung:Background and Purpose The objective ofthis study was to demonstrate a global cerebrospinal fluid (CSF) method for a consistent and automated zero referencing of brain quantitative susceptibility mapping (QSM). Methods Whole brain CSF mask was automatically segmented by thresholding the gradient echo transverse relaxation (R2∗) map, and regularization was employed to enforce uniform susceptibility distribution within the CSF volume in the field‐to‐susceptibility inversion. This global CSF regularization method was compared with a prior ventricular CSF regularization. Both reconstruction methods were compared in a repeatability study of 12 healthy subjects using t‐test on susceptibility measurements, and in patient studies of 17 multiple sclerosis (MS) and 10 Parkinson's disease (PD) patients using Wilcoxon rank‐sum test on radiological scores. Results In scan‐rescan experiments, global CSF regularization provided more consistent CSF volume as well as higher repeatability of QSM measurements than ventricular CSF regularization with a smaller bias: –2.7 parts per billion (ppb) versus –0.13 ppb (t‐test p<0.05) and a narrower 95% limits of agreement: [−7.25, 6.99] ppb versus [−16.60, 11.19 ppb] (f‐test p<0.05). In PD and MS patients, global CSF regularization reduced smoothly varying shadow artifacts and significantly improved the QSM quality score (p<0.001). Conclusions The proposed whole brain CSF method for QSM zero referencing improves repeatability and image quality of brain QSM compared to the ventricular CSF method.
Bibliographie:Funding information
This work was supported in part by the NIH R01NS105144, R01NS095562, R21AG067466, and S10OD021782
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ISSN:1051-2284
1552-6569
1552-6569
DOI:10.1111/jon.12923