Characterization of the 18 kDa translocator protein (TSPO) expression in post‐mortem normal and Alzheimer's disease brains

The 18 kDa translocator protein (TSPO) is a widely used target for microglial PET imaging radioligands, but its expression in post‐mortem normal and diseased human brain is not well described. We aimed at characterizing the TSPO expression in human control (CTRL) and Alzheimer's disease (AD) br...

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Bibliographic Details
Published in:	Brain pathology (Zurich, Switzerland) Vol. 30; no. 1; pp. 151 - 164
Main Authors:	Gui, Yaxing, Marks, Jordan D., Das, Sudeshna, Hyman, Bradley T., Serrano‐Pozo, Alberto
Format:	Journal Article
Language:	English
Published:	Switzerland John Wiley & Sons, Inc 01.01.2020 John Wiley and Sons Inc
Subjects:	18 kDa translocator protein (TSPO) Alzheimer Disease - genetics Alzheimer Disease - pathology Alzheimer's disease amyloid plaques Astrocytes Astrocytes - pathology Autopsy - methods Brain Brain - pathology Cerebral cortex Disease control Endothelial cells Endothelial Cells - pathology Gene Expression - genetics Humans Immunohistochemistry Longitudinal Studies Microglia Microglia - pathology mRNA Muscles Neocortex Neurodegenerative diseases Neurofibrillary tangles Neurofibrillary Tangles - metabolism Neuroglia - pathology Neuroimaging neuroinflammation Neuronal-glial interactions Neuropathology peripheral benzodiazepine receptor Plaque, Amyloid - pathology Positron emission Positron emission tomography positron emission tomography (PET) Proteins Radioisotopes Receptors, GABA - genetics Receptors, GABA - metabolism rs6971 SNP Senile plaques Smooth muscle Substantia alba Target recognition Thickness Tomography Transcriptome - genetics rs6971 SNP neuroinflammation positron emission tomography (PET) neurofibrillary tangles peripheral benzodiazepine receptor 18 kDa translocator protein (TSPO) astrocytes Alzheimer's disease microglia amyloid plaques
ISSN:	1015-6305, 1750-3639, 1750-3639
Online Access:	Get full text
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