Established and emerging therapeutic uses of PDE type 5 inhibitors in cardiovascular disease

PDE type 5 inhibitors (PDE5Is), such as sildenafil, tadalafil and vardenafil, are a class of drugs used to prolong the physiological effects of NO/cGMP signalling in tissues through the inhibition of cGMP degradation. Although these agents were originally developed for the treatment of hypertension...

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Bibliographic Details

Published in:	British journal of pharmacology Vol. 177; no. 24; pp. 5467 - 5488
Main Authors:	Tzoumas, Nikolaos, Farrah, Tariq E., Dhaun, Neeraj, Webb, David J.
Format:	Journal Article
Language:	English
Published:	England Blackwell Publishing Ltd 01.12.2020 John Wiley and Sons Inc
Subjects:	Angina Cardiovascular diseases Cerebral infarction Cyclic GMP Diabetes mellitus Erectile dysfunction Hypertension Kidney diseases Myocardial infarction Review Sildenafil TARGETING THE NITRIC OXIDE (NO)‐cGMP PATHWAY: THERAPEUTIC OPPORTUNITIES IN THE 21ST CENTURY
ISSN:	0007-1188, 1476-5381, 1476-5381
Online Access:	Get full text
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