Bio-computational modeling, POM analysis and molecular dynamic simulation for novel synthetic quinolone and benzo[d][1,3]oxazine candidates as antimicrobial inhibitors

The current study offers a metal-free, direct, and successful synthesis technique for a new series of quinolinone and benzo[d][1,3]oxazine, along with an assessment of their biological activities. Heteroannulation of anthranilic acid with carbonyl-containing chemicals (aroyl pyruvate, ethyl acetoace...

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Vydáno v:	Scientific reports Ročník 14; číslo 1; s. 28709 - 19
Hlavní autoři:	Elsayed, Doaa A., Abdu, Mohamed E., Marzouk, Mohammed A., Mahmoud, Elsayed M., El-Shwiniy, Walaa H., Spring, Andrew M., Shehab, Wesam S.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 20.11.2024 Nature Publishing Group Nature Portfolio
Témata:	639/638 639/638/403 Anthranilic acid Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Anti-Infective Agents - chemical synthesis Anti-Infective Agents - chemistry Anti-Infective Agents - pharmacology Antibacterial agents Antifungal activity Antifungal agents Antimicrobial Benzoxazines - chemical synthesis Benzoxazines - chemistry Benzoxazines - pharmacology Bio-computational modeling Carbonyl compounds Chemotherapy Cytotoxicity Doxorubicin Humanities and Social Sciences Humans Microbial Sensitivity Tests Molecular Docking Simulation Molecular dynamic simulation Molecular Dynamics Simulation multidisciplinary Oxazine POM analysis Pyruvic acid Quinolone Quinolones Quinolones - chemical synthesis Quinolones - chemistry Quinolones - pharmacology Science Science (multidisciplinary) Toxicity Antimicrobial Quinolone Bio-computational modeling Molecular dynamic simulation POM analysis
ISSN:	2045-2322, 2045-2322
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