Phylodynamics of H1N1/2009 influenza reveals the transition from host adaptation to immune-driven selection

Influenza A H1N1/2009 virus that emerged from swine rapidly replaced the previous seasonal H1N1 virus. Although the early emergence and diversification of H1N1/2009 is well characterized, the ongoing evolutionary and global transmission dynamics of the virus remain poorly investigated. To address th...

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Vydáno v:Nature communications Ročník 6; číslo 1; s. 7952
Hlavní autoři: Su, Yvonne C. F., Bahl, Justin, Joseph, Udayan, Butt, Ka Man, Peck, Heidi A., Koay, Evelyn S. C., Oon, Lynette L. E., Barr, Ian G., Vijaykrishna, Dhanasekaran, Smith, Gavin J. D.
Médium: Journal Article
Jazyk:angličtina
Vydáno: London Nature Publishing Group UK 06.08.2015
Nature Publishing Group
Témata:
631/208/212/2306
631/208/457
631/326/596/2554
82/1
Adaptation
Adaptation, Biological
Animals
Dogs
Epidemiology
Evolution & development
Evolution, Molecular
Genetic diversity
Genome, Viral
Genomes
Host-Pathogen Interactions - genetics
Host-Pathogen Interactions - immunology
Humanities and Social Sciences
Humans
Infections
Influenza A Virus, H1N1 Subtype - genetics
Influenza A Virus, H1N1 Subtype - immunology
Madin Darby Canine Kidney Cells
Molecular Sequence Data
multidisciplinary
Pandemics
Phylogeny
Phylogeography
Science
Science (multidisciplinary)
Selection, Genetic
Swine flu
Vaccines
Viruses
United States > US
Singapore
ISSN:2041-1723, 2041-1723
On-line přístup:Získat plný text
Tagy: Přidat tag
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Abstract Influenza A H1N1/2009 virus that emerged from swine rapidly replaced the previous seasonal H1N1 virus. Although the early emergence and diversification of H1N1/2009 is well characterized, the ongoing evolutionary and global transmission dynamics of the virus remain poorly investigated. To address this we analyse >3,000 H1N1/2009 genomes, including 214 full genomes generated from our surveillance in Singapore, in conjunction with antigenic data. Here we show that natural selection acting on H1N1/2009 directly after introduction into humans was driven by adaptation to the new host. Since then, selection has been driven by immunological escape, with these changes corresponding to restricted antigenic diversity in the virus population. We also show that H1N1/2009 viruses have been subject to regular seasonal bottlenecks and a global reduction in antigenic and genetic diversity in 2014. Influenza A H1N1/2009 virus emerged from swine and rapidly replaced the seasonal H1N1 virus. Here, the authors show that natural selection acting on H1N1/2009 after introduction into humans was driven by adaptation to the new host but later selection has been driven by immunological escape.
AbstractList Influenza A H1N1/2009 virus that emerged from swine rapidly replaced the previous seasonal H1N1 virus. Although the early emergence and diversification of H1N1/2009 is well characterized, the ongoing evolutionary and global transmission dynamics of the virus remain poorly investigated. To address this we analyse >3,000 H1N1/2009 genomes, including 214 full genomes generated from our surveillance in Singapore, in conjunction with antigenic data. Here we show that natural selection acting on H1N1/2009 directly after introduction into humans was driven by adaptation to the new host. Since then, selection has been driven by immunological escape, with these changes corresponding to restricted antigenic diversity in the virus population. We also show that H1N1/2009 viruses have been subject to regular seasonal bottlenecks and a global reduction in antigenic and genetic diversity in 2014. Influenza A H1N1/2009 virus emerged from swine and rapidly replaced the seasonal H1N1 virus. Here, the authors show that natural selection acting on H1N1/2009 after introduction into humans was driven by adaptation to the new host but later selection has been driven by immunological escape.
Influenza A H1N1/2009 virus that emerged from swine rapidly replaced the previous seasonal H1N1 virus. Although the early emergence and diversification of H1N1/2009 is well characterized, the ongoing evolutionary and global transmission dynamics of the virus remain poorly investigated. To address this we analyse >3,000 H1N1/2009 genomes, including 214 full genomes generated from our surveillance in Singapore, in conjunction with antigenic data. Here we show that natural selection acting on H1N1/2009 directly after introduction into humans was driven by adaptation to the new host. Since then, selection has been driven by immunological escape, with these changes corresponding to restricted antigenic diversity in the virus population. We also show that H1N1/2009 viruses have been subject to regular seasonal bottlenecks and a global reduction in antigenic and genetic diversity in 2014.
Influenza A H1N1/2009 virus that emerged from swine rapidly replaced the previous seasonal H1N1 virus. Although the early emergence and diversification of H1N1/2009 is well characterized, the ongoing evolutionary and global transmission dynamics of the virus remain poorly investigated. To address this we analyse >3,000 H1N1/2009 genomes, including 214 full genomes generated from our surveillance in Singapore, in conjunction with antigenic data. Here we show that natural selection acting on H1N1/2009 directly after introduction into humans was driven by adaptation to the new host. Since then, selection has been driven by immunological escape, with these changes corresponding to restricted antigenic diversity in the virus population. We also show that H1N1/2009 viruses have been subject to regular seasonal bottlenecks and a global reduction in antigenic and genetic diversity in 2014.Influenza A H1N1/2009 virus that emerged from swine rapidly replaced the previous seasonal H1N1 virus. Although the early emergence and diversification of H1N1/2009 is well characterized, the ongoing evolutionary and global transmission dynamics of the virus remain poorly investigated. To address this we analyse >3,000 H1N1/2009 genomes, including 214 full genomes generated from our surveillance in Singapore, in conjunction with antigenic data. Here we show that natural selection acting on H1N1/2009 directly after introduction into humans was driven by adaptation to the new host. Since then, selection has been driven by immunological escape, with these changes corresponding to restricted antigenic diversity in the virus population. We also show that H1N1/2009 viruses have been subject to regular seasonal bottlenecks and a global reduction in antigenic and genetic diversity in 2014.
Influenza A H1N1/2009 virus that emerged from swine rapidly replaced the previous seasonal H1N1 virus. Although the early emergence and diversification of H1N1/2009 is well characterized, the ongoing evolutionary and global transmission dynamics of the virus remain poorly investigated. To address this we analyse >3,000 H1N1/2009 genomes, including 214 full genomes generated from our surveillance in Singapore, in conjunction with antigenic data. Here we show that natural selection acting on H1N1/2009 directly after introduction into humans was driven by adaptation to the new host. Since then, selection has been driven by immunological escape, with these changes corresponding to restricted antigenic diversity in the virus population. We also show that H1N1/2009 viruses have been subject to regular seasonal bottlenecks and a global reduction in antigenic and genetic diversity in 2014. Influenza A H1N1/2009 virus emerged from swine and rapidly replaced the seasonal H1N1 virus. Here, the authors show that natural selection acting on H1N1/2009 after introduction into humans was driven by adaptation to the new host but later selection has been driven by immunological escape.
ArticleNumber 7952
Author Peck, Heidi A.
Su, Yvonne C. F.
Oon, Lynette L. E.
Vijaykrishna, Dhanasekaran
Bahl, Justin
Barr, Ian G.
Smith, Gavin J. D.
Koay, Evelyn S. C.
Butt, Ka Man
Joseph, Udayan
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  surname: Su
  fullname: Su, Yvonne C. F.
  email: yvonne.su@duke-nus.edu.sg
  organization: Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School
– sequence: 2
  givenname: Justin
  orcidid: 0000-0001-7572-4300
  surname: Bahl
  fullname: Bahl, Justin
  organization: Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School, Division of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas
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  givenname: Udayan
  surname: Joseph
  fullname: Joseph, Udayan
  organization: Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School
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  givenname: Ka Man
  surname: Butt
  fullname: Butt, Ka Man
  organization: Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School
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  givenname: Heidi A.
  surname: Peck
  fullname: Peck, Heidi A.
  organization: World Health Organisation Collaborating Centre for Reference and Research on Influenza
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  givenname: Evelyn S. C.
  surname: Koay
  fullname: Koay, Evelyn S. C.
  organization: Department of Laboratory Medicine, Molecular Diagnosis Centre, National University Hospital
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  givenname: Lynette L. E.
  surname: Oon
  fullname: Oon, Lynette L. E.
  organization: Department of Pathology, Singapore General Hospital
– sequence: 8
  givenname: Ian G.
  surname: Barr
  fullname: Barr, Ian G.
  organization: World Health Organisation Collaborating Centre for Reference and Research on Influenza
– sequence: 9
  givenname: Dhanasekaran
  surname: Vijaykrishna
  fullname: Vijaykrishna, Dhanasekaran
  organization: Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School, World Health Organisation Collaborating Centre for Reference and Research on Influenza, Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore
– sequence: 10
  givenname: Gavin J. D.
  orcidid: 0000-0001-5031-468X
  surname: Smith
  fullname: Smith, Gavin J. D.
  email: gavin.smith@duke-nus.edu.sg
  organization: Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School, World Health Organisation Collaborating Centre for Reference and Research on Influenza, Duke Global Health Institute, Duke University
BackLink https://www.ncbi.nlm.nih.gov/pubmed/26245473$$D View this record in MEDLINE/PubMed
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ContentType Journal Article
Copyright The Author(s) 2015
Copyright Nature Publishing Group Aug 2015
Copyright © 2015, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. 2015 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.
Copyright_xml – notice: The Author(s) 2015
– notice: Copyright Nature Publishing Group Aug 2015
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Snippet Influenza A H1N1/2009 virus that emerged from swine rapidly replaced the previous seasonal H1N1 virus. Although the early emergence and diversification of...
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proquest
pubmed
crossref
springer
SourceType Open Access Repository
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Index Database
Enrichment Source
Publisher
StartPage 7952
SubjectTerms 631/208/212/2306
631/208/457
631/326/596/2554
82/1
Adaptation
Adaptation, Biological
Animals
Dogs
Epidemiology
Evolution & development
Evolution, Molecular
Genetic diversity
Genome, Viral
Genomes
Host-Pathogen Interactions - genetics
Host-Pathogen Interactions - immunology
Humanities and Social Sciences
Humans
Infections
Influenza A Virus, H1N1 Subtype - genetics
Influenza A Virus, H1N1 Subtype - immunology
Madin Darby Canine Kidney Cells
Molecular Sequence Data
multidisciplinary
Pandemics
Phylogeny
Phylogeography
Science
Science (multidisciplinary)
Selection, Genetic
Swine flu
Vaccines
Viruses
Title Phylodynamics of H1N1/2009 influenza reveals the transition from host adaptation to immune-driven selection
URI https://link.springer.com/article/10.1038/ncomms8952
https://www.ncbi.nlm.nih.gov/pubmed/26245473
https://www.proquest.com/docview/1701896475
https://www.proquest.com/docview/1702649793
https://pubmed.ncbi.nlm.nih.gov/PMC4918339
Volume 6
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