Phylodynamics of H1N1/2009 influenza reveals the transition from host adaptation to immune-driven selection

Influenza A H1N1/2009 virus that emerged from swine rapidly replaced the previous seasonal H1N1 virus. Although the early emergence and diversification of H1N1/2009 is well characterized, the ongoing evolutionary and global transmission dynamics of the virus remain poorly investigated. To address th...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Nature communications Ročník 6; číslo 1; s. 7952
Hlavní autoři: Su, Yvonne C. F., Bahl, Justin, Joseph, Udayan, Butt, Ka Man, Peck, Heidi A., Koay, Evelyn S. C., Oon, Lynette L. E., Barr, Ian G., Vijaykrishna, Dhanasekaran, Smith, Gavin J. D.
Médium: Journal Article
Jazyk:angličtina
Vydáno: London Nature Publishing Group UK 06.08.2015
Nature Publishing Group
Témata:
631/208/212/2306
631/208/457
631/326/596/2554
82/1
Adaptation
Adaptation, Biological
Animals
Dogs
Epidemiology
Evolution & development
Evolution, Molecular
Genetic diversity
Genome, Viral
Genomes
Host-Pathogen Interactions - genetics
Host-Pathogen Interactions - immunology
Humanities and Social Sciences
Humans
Infections
Influenza A Virus, H1N1 Subtype - genetics
Influenza A Virus, H1N1 Subtype - immunology
Madin Darby Canine Kidney Cells
Molecular Sequence Data
multidisciplinary
Pandemics
Phylogeny
Phylogeography
Science
Science (multidisciplinary)
Selection, Genetic
Swine flu
Vaccines
Viruses
United States > US
Singapore
ISSN:2041-1723, 2041-1723
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:Influenza A H1N1/2009 virus that emerged from swine rapidly replaced the previous seasonal H1N1 virus. Although the early emergence and diversification of H1N1/2009 is well characterized, the ongoing evolutionary and global transmission dynamics of the virus remain poorly investigated. To address this we analyse >3,000 H1N1/2009 genomes, including 214 full genomes generated from our surveillance in Singapore, in conjunction with antigenic data. Here we show that natural selection acting on H1N1/2009 directly after introduction into humans was driven by adaptation to the new host. Since then, selection has been driven by immunological escape, with these changes corresponding to restricted antigenic diversity in the virus population. We also show that H1N1/2009 viruses have been subject to regular seasonal bottlenecks and a global reduction in antigenic and genetic diversity in 2014. Influenza A H1N1/2009 virus emerged from swine and rapidly replaced the seasonal H1N1 virus. Here, the authors show that natural selection acting on H1N1/2009 after introduction into humans was driven by adaptation to the new host but later selection has been driven by immunological escape.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ISSN:2041-1723
2041-1723
DOI:10.1038/ncomms8952