Frequency of alcohol consumption in humans; the role of metabotropic glutamate receptors and downstream signaling pathways

Rodent models implicate metabotropic glutamate receptors (mGluRs) and downstream signaling pathways in addictive behaviors through metaplasticity. One way mGluRs can influence synaptic plasticity is by regulating the local translation of AMPA receptor trafficking proteins via eukaryotic elongation f...

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Bibliographic Details
Published in:	Translational psychiatry Vol. 5; no. 6; p. e586
Main Authors:	Meyers, J L, Salling, M C, Almli, L M, Ratanatharathorn, A, Uddin, M, Galea, S, Wildman, D E, Aiello, A E, Bradley, B, Ressler, K, Koenen, K C
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 23.06.2015 Nature Publishing Group
Subjects:	38/43 49/39 631/208/212 Adult Aged Alcohol Drinking - genetics Behavioral Sciences Biological Psychology Calcium-Calmodulin-Dependent Protein Kinase Type 2 - genetics Carrier Proteins - genetics Cytoskeletal Proteins - genetics Elongation Factor 2 Kinase - genetics Eukaryotic Initiation Factor-2 - genetics Eukaryotic Initiation Factor-4E - genetics Female Homer Scaffolding Proteins Humans Linear Models Male Medicine Medicine & Public Health Middle Aged Nerve Tissue Proteins - genetics Neuronal Plasticity - genetics Neurosciences Original original-article Pharmacotherapy Polymorphism, Single Nucleotide Psychiatry Receptor, Metabotropic Glutamate 5 - genetics Receptors, AMPA - genetics Receptors, Metabotropic Glutamate - genetics Signal Transduction - genetics TOR Serine-Threonine Kinases - genetics
ISSN:	2158-3188, 2158-3188
Online Access:	Get full text
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