Nonhuman Primate Optogenetics: Recent Advances and Future Directions

Optogenetics is the use of genetically coded, light-gated ion channels or pumps (opsins) for millisecond resolution control of neural activity. By targeting opsin expression to specific cell types and neuronal pathways, optogenetics can expand our understanding of the neural basis of normal and path...

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Vydáno v:The Journal of neuroscience Ročník 37; číslo 45; s. 10894
Hlavní autoři: Galvan, Adriana, Stauffer, William R, Acker, Leah, El-Shamayleh, Yasmine, Inoue, Ken-Ichi, Ohayon, Shay, Schmid, Michael C
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 08.11.2017
Témata:
Animals
Brain - physiology
Humans
Neurology - methods
Neurology - trends
Optogenetics - instrumentation
Optogenetics - methods
Optogenetics - trends
Primates - physiology
promoter
monkey
optrode
optogenetic
opsins
NHP
ISSN:1529-2401, 1529-2401
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Shrnutí:Optogenetics is the use of genetically coded, light-gated ion channels or pumps (opsins) for millisecond resolution control of neural activity. By targeting opsin expression to specific cell types and neuronal pathways, optogenetics can expand our understanding of the neural basis of normal and pathological behavior. To maximize the potential of optogenetics to study human cognition and behavior, optogenetics should be applied to the study of nonhuman primates (NHPs). The homology between NHPs and humans makes these animals the best experimental model for understanding human brain function and dysfunction. Moreover, for genetic tools to have translational promise, their use must be demonstrated effectively in large, wild-type animals such as Rhesus macaques. Here, we review recent advances in primate optogenetics. We highlight the technical hurdles that have been cleared, challenges that remain, and summarize how optogenetic experiments are expanding our understanding of primate brain function.
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ISSN:1529-2401
1529-2401
DOI:10.1523/JNEUROSCI.1839-17.2017