Effect of reducing the dose of stavudine on body composition, bone density, and markers of mitochondrial toxicity in HIV-infected subjects: a randomized, controlled study

Stavudine is widely used in developing countries. Lipoatrophy and mitochondrial toxicity have been linked to stavudine use, but it is unclear whether switching to a lower dose can reduce these toxicities while maintaining human immunodeficiency virus (HIV) suppression. HIV-infected subjects receivin...

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Veröffentlicht in:	Clinical infectious diseases Jg. 46; H. 8; S. 1290
Hauptverfasser:	McComsey, G A, Lo Re, 3rd, V, O'Riordan, M, Walker, U A, Lebrecht, D, Baron, E, Mounzer, K, Frank, I
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 15.04.2008
Schlagworte:	Adipose Tissue - cytology Adipose Tissue - drug effects Adipose Tissue - metabolism Adult Anti-HIV Agents - adverse effects Anti-HIV Agents - therapeutic use Body Composition - drug effects Bone Density - drug effects DNA, Mitochondrial - drug effects DNA, Mitochondrial - genetics Female Genotype HIV Infections - drug therapy HIV Infections - genetics HIV Infections - metabolism Humans Lactic Acid - metabolism Leukocytes, Mononuclear - cytology Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - metabolism Male Middle Aged Pyruvic Acid - metabolism Stavudine - adverse effects Stavudine - therapeutic use
ISSN:	1537-6591, 1537-6591
Online-Zugang:	Weitere Angaben
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