Replicative history marks transcriptional and functional disparity in the CD8 + T cell memory pool

Clonal expansion is a core aspect of T cell immunity. However, little is known with respect to the relationship between replicative history and the formation of distinct CD8 memory T cell subgroups. To address this issue, we developed a genetic-tracing approach, termed the DivisionRecorder, that rep...

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Bibliographic Details

Published in:	Nature immunology Vol. 23; no. 5; pp. 791 - 801
Main Authors:	Bresser, Kaspar, Kok, Lianne, Swain, Arpit C, King, Lisa A, Jacobs, Laura, Weber, Tom S, Perié, Leïla, Duffy, Ken R, de Boer, Rob J, Scheeren, Ferenc A, Schumacher, Ton N
Format:	Journal Article
Language:	English
Published:	United States Nature Publishing Group 01.05.2022
Subjects:	CD8 antigen CD8-Positive T-Lymphocytes Immune clearance Immune response Immunologic Memory Immunological memory Lymphocytes Lymphocytes T Memory cells Pathogens Stem cells Transcriptomics
ISSN:	1529-2908, 1529-2916, 1529-2916
Online Access:	Get full text
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