Replicative history marks transcriptional and functional disparity in the CD8 + T cell memory pool

Clonal expansion is a core aspect of T cell immunity. However, little is known with respect to the relationship between replicative history and the formation of distinct CD8 memory T cell subgroups. To address this issue, we developed a genetic-tracing approach, termed the DivisionRecorder, that rep...

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Vydáno v:	Nature immunology Ročník 23; číslo 5; s. 791 - 801
Hlavní autoři:	Bresser, Kaspar, Kok, Lianne, Swain, Arpit C, King, Lisa A, Jacobs, Laura, Weber, Tom S, Perié, Leïla, Duffy, Ken R, de Boer, Rob J, Scheeren, Ferenc A, Schumacher, Ton N
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Nature Publishing Group 01.05.2022
Témata:	CD8 antigen CD8-Positive T-Lymphocytes Immune clearance Immune response Immunologic Memory Immunological memory Lymphocytes Lymphocytes T Memory cells Pathogens Stem cells Transcriptomics
ISSN:	1529-2908, 1529-2916, 1529-2916
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