The functional roles of TCA cycle metabolites in cancer

The tricarboxylic acid cycle (TCA cycle) has been known for decades as a hub for generating cellular energy and precursors for biosynthetic pathways. Several cancers harbor mutations that affect the integrity of this cycle, mostly at the levels of isocitrate dehydrogenase (IDH), succinate dehydrogen...

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Bibliographic Details
Published in:	Oncogene Vol. 40; no. 19; pp. 3351 - 3363
Main Authors:	Eniafe, Joseph, Jiang, Shuai
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 13.05.2021 Nature Publishing Group
Subjects:	42/41 631/67/1059 631/67/2327 Apoptosis Cancer Cell Biology Citric Acid Cycle Dehydrogenases Development and progression Fumarate hydratase Fumarate Hydratase - metabolism Genetic aspects Health aspects Human Genetics Humans Intermediates Internal Medicine Isocitrate dehydrogenase Isocitrate Dehydrogenase - metabolism Krebs cycle Medicine Medicine & Public Health Metabolites Metabolome Molecular modelling Mutation Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Oncology Review Article Succinate dehydrogenase Succinate Dehydrogenase - metabolism Tricarboxylic acid cycle Tumorigenesis United States
ISSN:	0950-9232, 1476-5594, 1476-5594
Online Access:	Get full text
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