High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions

Somatic mutations activating telomerase reverse-trancriptase promoter were recently identified in several tumour types. Here we identify frequent similar mutations in human hepatocellular carcinomas (59%), cirrhotic preneoplastic macronodules (25%) and hepatocellular adenomas with malignant transfor...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	Nature communications Ročník 4; číslo 1; s. 2218
Hlavní autoři:	Nault, Jean Charles, Mallet, Maxime, Pilati, Camilla, Calderaro, Julien, Bioulac-Sage, Paulette, Laurent, Christophe, Laurent, Alexis, Cherqui, Daniel, Balabaud, Charles, Zucman-Rossi, Jessica
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 26.07.2013 Nature Publishing Group Nature Pub. Group
Témata:	631/208/68 631/67/1504/1610 Adenoma, Liver Cell - genetics Adenoma, Liver Cell - metabolism Adenoma, Liver Cell - pathology Aged Base Sequence beta Catenin - genetics beta Catenin - metabolism Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Female Gene Expression Humanities and Social Sciences Humans Lesions Liver - metabolism Liver - pathology Liver Cirrhosis - genetics Liver Cirrhosis - metabolism Liver Cirrhosis - pathology Liver Neoplasms - genetics Liver Neoplasms - metabolism Liver Neoplasms - pathology Male Middle Aged Molecular Sequence Data multidisciplinary Mutation Precancerous Conditions - genetics Precancerous Conditions - metabolism Precancerous Conditions - pathology Promoter Regions, Genetic RNA, Messenger - genetics RNA, Messenger - metabolism Science Science (multidisciplinary) Telomerase - genetics Telomerase - metabolism
ISSN:	2041-1723, 2041-1723
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Buďte první, kdo okomentuje tento záznam!