High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions

Somatic mutations activating telomerase reverse-trancriptase promoter were recently identified in several tumour types. Here we identify frequent similar mutations in human hepatocellular carcinomas (59%), cirrhotic preneoplastic macronodules (25%) and hepatocellular adenomas with malignant transfor...

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Bibliographic Details
Published in:	Nature communications Vol. 4; no. 1; p. 2218
Main Authors:	Nault, Jean Charles, Mallet, Maxime, Pilati, Camilla, Calderaro, Julien, Bioulac-Sage, Paulette, Laurent, Christophe, Laurent, Alexis, Cherqui, Daniel, Balabaud, Charles, Zucman-Rossi, Jessica
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 26.07.2013 Nature Publishing Group Nature Pub. Group
Subjects:	631/208/68 631/67/1504/1610 Adenoma, Liver Cell - genetics Adenoma, Liver Cell - metabolism Adenoma, Liver Cell - pathology Aged Base Sequence beta Catenin - genetics beta Catenin - metabolism Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Female Gene Expression Humanities and Social Sciences Humans Lesions Liver - metabolism Liver - pathology Liver Cirrhosis - genetics Liver Cirrhosis - metabolism Liver Cirrhosis - pathology Liver Neoplasms - genetics Liver Neoplasms - metabolism Liver Neoplasms - pathology Male Middle Aged Molecular Sequence Data multidisciplinary Mutation Precancerous Conditions - genetics Precancerous Conditions - metabolism Precancerous Conditions - pathology Promoter Regions, Genetic RNA, Messenger - genetics RNA, Messenger - metabolism Science Science (multidisciplinary) Telomerase - genetics Telomerase - metabolism
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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