Characterization of Immune Responses Induced by Ebola Virus Glycoprotein (GP) and Truncated GP Isoform DNA Vaccines and Protection Against Lethal Ebola Virus Challenge in Mice

In addition to its surface glycoprotein (GP), Ebola virus directs the production of large quantities of a truncated glycoprotein isoform (sGP) that is secreted into the extracellular space. We recently reported that sGP actively diverts host antibody responses against the epitopes that it shares wit...

Full description

Saved in:

Bibliographic Details
Published in:	The Journal of infectious diseases Vol. 212 Suppl 2; p. S398
Main Authors:	Li, Wenfang, Ye, Ling, Carrion, Jr, Ricardo, Mohan, Gopi S, Nunneley, Jerritt, Staples, Hilary, Ticer, Anysha, Patterson, Jean L, Compans, Richard W, Yang, Chinglai
Format:	Journal Article
Language:	English
Published:	United States 01.10.2015
Subjects:	Animals Antibodies, Viral - immunology Antibody Formation - immunology Ebola Vaccines - immunology Ebolavirus - immunology Female Glycoproteins - immunology HEK293 Cells Hemorrhagic Fever, Ebola - immunology Hemorrhagic Fever, Ebola - virology Humans Immunization, Secondary - methods Mice Mice, Inbred BALB C Protein Isoforms - immunology Vaccination - methods Vaccines, DNA - immunology Viral Proteins - immunology antigenic subversion vaccine Ebola soluble GP
ISSN:	1537-6613, 1537-6613
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!