Low MITF/AXL ratio predicts early resistance to multiple targeted drugs in melanoma

Increased expression of the Microphthalmia-associated transcription factor (MITF) contributes to melanoma progression and resistance to BRAF pathway inhibition. Here we show that the lack of MITF is associated with more severe resistance to a range of inhibitors, while its presence is required for r...

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Bibliographic Details
Published in:	Nature communications Vol. 5; no. 1; p. 5712
Main Authors:	Müller, Judith, Krijgsman, Oscar, Tsoi, Jennifer, Robert, Lidia, Hugo, Willy, Song, Chunying, Kong, Xiangju, Possik, Patricia A., Cornelissen-Steijger, Paulien D. M., Foppen, Marnix H Geukes, Kemper, Kristel, Goding, Colin R., McDermott, Ultan, Blank, Christian, Haanen, John, Graeber, Thomas G., Ribas, Antoni, Lo, Roger S., Peeper, Daniel S.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 15.12.2014 Nature Publishing Group
Subjects:	13 38 631/154/53/2423 631/67/1059/2326 631/67/1813/1634 82 96 Aminopyridines - pharmacology Animals Antineoplastic Agents - pharmacology Benzamides - pharmacology Cell Line, Tumor Drug Resistance, Neoplasm - genetics Extracellular Signal-Regulated MAP Kinases - genetics Extracellular Signal-Regulated MAP Kinases - metabolism Gene Expression Regulation, Neoplastic Humanities and Social Sciences Humans Imatinib Mesylate Imidazoles - pharmacology Indoles - pharmacology Melanoma Melanoma - drug therapy Melanoma - genetics Melanoma - metabolism Melanoma - pathology Mice Microphthalmia-Associated Transcription Factor - genetics Microphthalmia-Associated Transcription Factor - metabolism multidisciplinary Oximes - pharmacology Piperazines - pharmacology Prognosis Protein Kinase Inhibitors - pharmacology Proto-Oncogene Proteins - antagonists & inhibitors Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins B-raf - antagonists & inhibitors Proto-Oncogene Proteins B-raf - genetics Proto-Oncogene Proteins B-raf - metabolism Pyridones - pharmacology Pyrimidines - pharmacology Pyrimidinones - pharmacology Receptor Protein-Tyrosine Kinases - antagonists & inhibitors Receptor Protein-Tyrosine Kinases - genetics Receptor Protein-Tyrosine Kinases - metabolism Science Science (multidisciplinary) Signal Transduction Skin Neoplasms - drug therapy Skin Neoplasms - genetics Skin Neoplasms - metabolism Skin Neoplasms - pathology Sulfonamides - pharmacology Xenograft Model Antitumor Assays
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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