Retinoid X Receptor: Cellular and Biochemical Roles of Nuclear Receptor with a Focus on Neuropathological Involvement

Retinoid X receptors (RXRs) present a subgroup of the nuclear receptor superfamily with particularly high evolutionary conservation of ligand binding domain. The receptor exists in α, β, and γ isotypes that form homo-/heterodimeric complexes with other permissive and non-permissive receptors. While...

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Bibliographic Details
Published in:	Molecular neurobiology Vol. 59; no. 4; pp. 2027 - 2050
Main Authors:	Sharma, Samridhi, Shen, Ting, Chitranshi, Nitin, Gupta, Veer, Basavarajappa, Devaraj, Sarkar, Soumalya, Mirzaei, Mehdi, You, Yuyi, Krezel, Wojciech, Graham, Stuart L., Gupta, Vivek
Format:	Journal Article
Language:	English
Published:	New York Springer US 01.04.2022 Springer Nature B.V Springer
Subjects:	Alzheimer's disease Animal models Animals Biomedical and Life Sciences Biomedicine Cell Biology Cell culture Evolutionary conservation Gene Expression Regulation Glaucoma Inflammation Isotypes Life Sciences Ligands Movement disorders Multiple sclerosis Nervous System Diseases Neurobiology Neurodegenerative diseases Neurological diseases Neurology Neurons and Cognition Neuropathology Neurosciences Parkinson's disease Receptors, Cytoplasmic and Nuclear - metabolism Retinoid X receptors Retinoid X Receptors - metabolism Structure-function relationships Therapeutic targets Lipid metabolism ligand Glaucoma Neuroprotection Bexarotene Multiple sclerosis Stroke Endogenous ligands Alzheimer disease Parkinson disease Neuroinflammation Lipid X receptor (LXR) Nuclear receptors Neuronal stress Exogenous ligands Glucose metabolism Nuclear receptor-related 1 (Nurr1) Retinoid X receptor (RXR) Peroxisome proliferator-activated receptor (PPAR) Heterodimerisation Neuroinfammation
ISSN:	0893-7648, 1559-1182, 1559-1182
Online Access:	Get full text
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