Retinoid X Receptor: Cellular and Biochemical Roles of Nuclear Receptor with a Focus on Neuropathological Involvement

Retinoid X receptors (RXRs) present a subgroup of the nuclear receptor superfamily with particularly high evolutionary conservation of ligand binding domain. The receptor exists in α, β, and γ isotypes that form homo-/heterodimeric complexes with other permissive and non-permissive receptors. While...

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Vydáno v:Molecular neurobiology Ročník 59; číslo 4; s. 2027 - 2050
Hlavní autoři: Sharma, Samridhi, Shen, Ting, Chitranshi, Nitin, Gupta, Veer, Basavarajappa, Devaraj, Sarkar, Soumalya, Mirzaei, Mehdi, You, Yuyi, Krezel, Wojciech, Graham, Stuart L., Gupta, Vivek
Médium: Journal Article
Jazyk:angličtina
Vydáno: New York Springer US 01.04.2022
Springer Nature B.V
Springer
Témata:
Alzheimer's disease
Animal models
Animals
Biomedical and Life Sciences
Biomedicine
Cell Biology
Cell culture
Evolutionary conservation
Gene Expression Regulation
Glaucoma
Inflammation
Isotypes
Life Sciences
Ligands
Movement disorders
Multiple sclerosis
Nervous System Diseases
Neurobiology
Neurodegenerative diseases
Neurological diseases
Neurology
Neurons and Cognition
Neuropathology
Neurosciences
Parkinson's disease
Receptors, Cytoplasmic and Nuclear - metabolism
Retinoid X receptors
Retinoid X Receptors - metabolism
Structure-function relationships
Therapeutic targets
Lipid metabolism ligand
Glaucoma
Neuroprotection
Bexarotene
Multiple sclerosis
Stroke
Endogenous ligands
Alzheimer disease
Parkinson disease
Neuroinflammation
Lipid X receptor (LXR)
Nuclear receptors
Neuronal stress
Exogenous ligands
Glucose metabolism
Nuclear receptor-related 1 (Nurr1)
Retinoid X receptor (RXR)
Peroxisome proliferator-activated receptor (PPAR)
Heterodimerisation
Neuroinfammation
ISSN:0893-7648, 1559-1182, 1559-1182
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Abstract Retinoid X receptors (RXRs) present a subgroup of the nuclear receptor superfamily with particularly high evolutionary conservation of ligand binding domain. The receptor exists in α, β, and γ isotypes that form homo-/heterodimeric complexes with other permissive and non-permissive receptors. While research has identified the biochemical roles of several nuclear receptor family members, the roles of RXRs in various neurological disorders remain relatively under-investigated. RXR acts as ligand-regulated transcription factor, modulating the expression of genes that plays a critical role in mediating several developmental, metabolic, and biochemical processes. Cumulative evidence indicates that abnormal RXR signalling affects neuronal stress and neuroinflammatory networks in several neuropathological conditions. Protective effects of targeting RXRs through pharmacological ligands have been established in various cell and animal models of neuronal injury including Alzheimer disease, Parkinson disease, glaucoma, multiple sclerosis, and stroke. This review summarises the existing knowledge about the roles of RXR, its interacting partners, and ligands in CNS disorders. Future research will determine the importance of structural and functional heterogeneity amongst various RXR isotypes as well as elucidate functional links between RXR homo- or heterodimers and specific physiological conditions to increase drug targeting efficiency in pathological conditions.
AbstractList Retinoid X receptors (RXRs) present a subgroup of the nuclear receptor superfamily with particularly high evolutionary conservation of ligand binding domain. The receptor exists in α, β, and γ isotypes that form homo-/heterodimeric complexes with other permissive and non-permissive receptors. While research has identified the biochemical roles of several nuclear receptor family members, the roles of RXRs in various neurological disorders remain relatively under-investigated. RXR acts as ligand-regulated transcription factor, modulating the expression of genes that plays a critical role in mediating several developmental, metabolic, and biochemical processes. Cumulative evidence indicates that abnormal RXR signalling affects neuronal stress and neuroinflammatory networks in several neuropathological conditions. Protective effects of targeting RXRs through pharmacological ligands have been established in various cell and animal models of neuronal injury including Alzheimer disease, Parkinson disease, glaucoma, multiple sclerosis, and stroke. This review summarises the existing knowledge about the roles of RXR, its interacting partners, and ligands in CNS disorders. Future research will determine the importance of structural and functional heterogeneity amongst various RXR isotypes as well as elucidate functional links between RXR homo- or heterodimers and specific physiological conditions to increase drug targeting efficiency in pathological conditions.Retinoid X receptors (RXRs) present a subgroup of the nuclear receptor superfamily with particularly high evolutionary conservation of ligand binding domain. The receptor exists in α, β, and γ isotypes that form homo-/heterodimeric complexes with other permissive and non-permissive receptors. While research has identified the biochemical roles of several nuclear receptor family members, the roles of RXRs in various neurological disorders remain relatively under-investigated. RXR acts as ligand-regulated transcription factor, modulating the expression of genes that plays a critical role in mediating several developmental, metabolic, and biochemical processes. Cumulative evidence indicates that abnormal RXR signalling affects neuronal stress and neuroinflammatory networks in several neuropathological conditions. Protective effects of targeting RXRs through pharmacological ligands have been established in various cell and animal models of neuronal injury including Alzheimer disease, Parkinson disease, glaucoma, multiple sclerosis, and stroke. This review summarises the existing knowledge about the roles of RXR, its interacting partners, and ligands in CNS disorders. Future research will determine the importance of structural and functional heterogeneity amongst various RXR isotypes as well as elucidate functional links between RXR homo- or heterodimers and specific physiological conditions to increase drug targeting efficiency in pathological conditions.
Retinoid X receptors (RXRs) present a subgroup of the nuclear receptor superfamily with particularly high evolutionary conservation of ligand binding domain. The receptor exists in α, β, and γ isotypes that form homo-/heterodimeric complexes with other permissive and non-permissive receptors. While research has identified the biochemical roles of several nuclear receptor family members, the roles of RXRs in various neurological disorders remain relatively under-investigated. RXR acts as ligand-regulated transcription factor, modulating the expression of genes that plays a critical role in mediating several developmental, metabolic, and biochemical processes. Cumulative evidence indicates that abnormal RXR signalling affects neuronal stress and neuroinflammatory networks in several neuropathological conditions. Protective effects of targeting RXRs through pharmacological ligands have been established in various cell and animal models of neuronal injury including Alzheimer disease, Parkinson disease, glaucoma, multiple sclerosis, and stroke. This review summarises the existing knowledge about the roles of RXR, its interacting partners, and ligands in CNS disorders. Future research will determine the importance of structural and functional heterogeneity amongst various RXR isotypes as well as elucidate functional links between RXR homo- or heterodimers and specific physiological conditions to increase drug targeting efficiency in pathological conditions.
Author Shen, Ting
Sharma, Samridhi
Mirzaei, Mehdi
Graham, Stuart L.
Chitranshi, Nitin
Sarkar, Soumalya
You, Yuyi
Basavarajappa, Devaraj
Krezel, Wojciech
Gupta, Veer
Gupta, Vivek
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/35015251$$D View this record in MEDLINE/PubMed
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1559-1182
IngestDate Tue Nov 04 02:02:28 EST 2025
Tue Nov 18 06:21:00 EST 2025
Thu Sep 04 16:58:52 EDT 2025
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Tue Nov 18 20:31:56 EST 2025
Fri Feb 21 02:46:30 EST 2025
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Issue 4
Keywords Lipid metabolism ligand
Glaucoma
Neuroprotection
Bexarotene
Multiple sclerosis
Stroke
Endogenous ligands
Alzheimer disease
Parkinson disease
Neuroinflammation
Lipid X receptor (LXR)
Nuclear receptors
Neuronal stress
Exogenous ligands
Glucose metabolism
Nuclear receptor-related 1 (Nurr1)
Retinoid X receptor (RXR)
Peroxisome proliferator-activated receptor (PPAR)
Heterodimerisation
Neuroinfammation
Language English
License 2021. The Author(s).
licence_http://creativecommons.org/publicdomain/zero/: http://creativecommons.org/publicdomain/zero
Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
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PublicationTitle Molecular neurobiology
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– reference: 35278210 - Mol Neurobiol. 2022 Mar 12;:
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Animal models
Animals
Biomedical and Life Sciences
Biomedicine
Cell Biology
Cell culture
Evolutionary conservation
Gene Expression Regulation
Glaucoma
Inflammation
Isotypes
Life Sciences
Ligands
Movement disorders
Multiple sclerosis
Nervous System Diseases
Neurobiology
Neurodegenerative diseases
Neurological diseases
Neurology
Neurons and Cognition
Neuropathology
Neurosciences
Parkinson's disease
Receptors, Cytoplasmic and Nuclear - metabolism
Retinoid X receptors
Retinoid X Receptors - metabolism
Structure-function relationships
Therapeutic targets
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