The role of the Nrf2/GSH antioxidant system in cisplatin resistance in malignant rhabdoid tumours

Purpose Malignant rhabdoid tumour (MRT) is a rare and aggressive childhood malignancy that occurs in the kidneys or central nervous system and is associated with very poor prognosis. Chemoresistance is a major issue in the treatment of this malignancy leading to an urgent need for a greater understa...

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Bibliographic Details
Published in:	Journal of cancer research and clinical oncology Vol. 149; no. 11; pp. 8379 - 8391
Main Authors:	Hannon Barroeta, Patricia, O’Sullivan, Maureen J., Zisterer, Daniela M.
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer Berlin Heidelberg 01.09.2023 Springer Nature B.V
Subjects:	Acetylcysteine antioxidant activity Antioxidants Antioxidants - pharmacology Apoptosis Buthionine Sulfoximine Cancer Research Cancer therapies cancer therapy Cell Line, Tumor Central nervous system Chemoresistance Chemotherapy Child childhood Children Cisplatin Cisplatin - pharmacology drug therapy Glutathione Glutathione - metabolism Hematology Humans Internal Medicine Malignancy Medicine Medicine & Public Health neoplasms NF-E2-Related Factor 2 - metabolism Oncology Oxidative stress prognosis Reactive oxygen species Reactive Oxygen Species - metabolism Rhabdoid Tumor - drug therapy siRNA transcription factors Tumors Reactive oxygen species Nuclear erythroid-related factor-2 Malignant rhabdoid tumour Chemoresistance Apoptosis Glutathione
ISSN:	0171-5216, 1432-1335, 1432-1335
Online Access:	Get full text
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