Identification of novel DNA-damage tolerance genes reveals regulation of translesion DNA synthesis by nucleophosmin

Cells cope with replication-blocking lesions via translesion DNA synthesis (TLS). TLS is carried out by low-fidelity DNA polymerases that replicate across lesions, thereby preventing genome instability at the cost of increased point mutations. Here we perform a two-stage siRNA-based functional scree...

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Bibliographic Details
Published in:	Nature communications Vol. 5; no. 1; p. 5437
Main Authors:	Ziv, Omer, Zeisel, Amit, Mirlas-Neisberg, Nataly, Swain, Umakanta, Nevo, Reinat, Ben-Chetrit, Nir, Martelli, Maria Paola, Rossi, Roberta, Schiesser, Stefan, Canman, Christine E., Carell, Thomas, Geacintov, Nicholas E., Falini, Brunangelo, Domany, Eytan, Livneh, Zvi
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 25.11.2014 Nature Publishing Group Nature Pub. Group
Subjects:	13 13/106 13/109 13/31 13/89 14 14/1 14/19 14/34 14/63 38 38/47 38/77 631/337/1427/2354 631/67/1990/283/1897 631/80/86 Cell Line Deoxyribonucleic acid DNA DNA Damage - radiation effects DNA Repair DNA Replication - radiation effects DNA-Directed DNA Polymerase - genetics DNA-Directed DNA Polymerase - metabolism Humanities and Social Sciences Humans Lesions Leukemia Leukemia, Myeloid, Acute - enzymology Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - metabolism multidisciplinary Mutation Nuclear Proteins - genetics Nuclear Proteins - metabolism Protein Binding Science Science (multidisciplinary) Ultraviolet Rays
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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