Liquid demixing of intrinsically disordered proteins is seeded by poly(ADP-ribose)

Intrinsically disordered proteins can phase separate from the soluble intracellular space, and tend to aggregate under pathological conditions. The physiological functions and molecular triggers of liquid demixing by phase separation are not well understood. Here we show in vitro and in vivo that th...

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Vydáno v:	Nature communications Ročník 6; číslo 1; s. 8088
Hlavní autoři:	Altmeyer, Matthias, Neelsen, Kai J., Teloni, Federico, Pozdnyakova, Irina, Pellegrino, Stefania, Grøfte, Merete, Rask, Maj-Britt Druedahl, Streicher, Werner, Jungmichel, Stephanie, Nielsen, Michael Lund, Lukas, Jiri
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 19.08.2015 Nature Publishing Group Nature Pub. Group
Témata:	14/1 14/28 14/35 14/63 631/337/1427 631/45 631/57/2269 Adenosine diphosphate Biopolymers Cell Line, Tumor Cloning, Molecular Deoxyribonucleic acid DNA DNA Damage Gene Expression Regulation - physiology Humanities and Social Sciences Humans multidisciplinary Nucleic acids Poly Adenosine Diphosphate Ribose - chemistry Protein Conformation Protein Structure, Tertiary Proteins - chemistry Proteins - genetics Proteins - metabolism Science Science (multidisciplinary)
ISSN:	2041-1723, 2041-1723
On-line přístup:	Získat plný text
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