Detection and characterization of H5N1 HPAIV in environmental samples from a dairy farm

The recent expansion of HPAIV H5N1 infections in terrestrial mammals in the Americas, most recently including the outbreak in dairy cattle, emphasizes the critical need for better epidemiological monitoring of zoonotic diseases. In this work, we detected, isolated, and characterized the HPAIV H5N1 f...

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Vydáno v:	Virus genes Ročník 60; číslo 5; s. 517 - 527
Hlavní autoři:	Singh, Gagandeep, Trujillo, Jessie D., McDowell, Chester D., Matias-Ferreyra, Franco, Kafle, Sujan, Kwon, Taeyong, Gaudreault, Natasha N., Fitz, Isaac, Noll, Lance, Morozov, Igor, Retallick, Jamie, Richt, Juergen A.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	New York Springer US 01.10.2024 Springer Nature B.V
Témata:	Animals Avian flu Biomedical and Life Sciences Biomedicine birds Cattle Cattle Diseases - epidemiology Cattle Diseases - virology Dairy cattle dairy farming Dairy farms Dairying Environmental monitoring Epidemiology Farms genes Genetic analysis genomics Humans Influenza A Virus, H5N1 Subtype - classification Influenza A Virus, H5N1 Subtype - genetics Influenza A Virus, H5N1 Subtype - isolation & purification Influenza A Virus, H5N1 Subtype - pathogenicity Kansas Medical Microbiology Original Paper Phylogenetics Phylogeny Plant Sciences Rare species species Virology viruses Whole genome sequencing Zoonoses Kansas H5N1 Environmental Highly pathogenic avian influenza virus Bovine Mammalian
ISSN:	0920-8569, 1572-994X, 1572-994X
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Abstract	The recent expansion of HPAIV H5N1 infections in terrestrial mammals in the Americas, most recently including the outbreak in dairy cattle, emphasizes the critical need for better epidemiological monitoring of zoonotic diseases. In this work, we detected, isolated, and characterized the HPAIV H5N1 from environmental swab samples collected from a dairy farm in the state of Kansas, USA. Genomic sequencing of these samples uncovered two distinctive substitutions in the PB2 (E249G) and NS1 (R21Q) genes which are rare and absent in recent 2024 isolates of H5N1 circulating in the mammalian and avian species. Additionally, approximately 1.7% of the sequence reads indicated a PB2 (E627K) substitution, commonly associated with virus adaptation to mammalian hosts. Phylogenetic analyses of the PB2 and NS genes demonstrated more genetic identity between this environmental isolate and the 2024 human isolate (A/Texas/37/2024) of H5N1. Conversely, HA and NA gene analyses revealed a closer relationship between our isolate and those found in other dairy cattle with almost 100% identity, sharing a common phylogenetic subtree. These findings underscore the rapid evolutionary progression of HPAIV H5N1 among dairy cattle and reinforces the need for more epidemiological monitoring which can be done using environmental sampling.
AbstractList	The recent expansion of HPAIV H5N1 infections in terrestrial mammals in the Americas, most recently including the outbreak in dairy cattle, emphasizes the critical need for better epidemiological monitoring of zoonotic diseases. In this work, we detected, isolated, and characterized the HPAIV H5N1 from environmental swab samples collected from a dairy farm in the state of Kansas, USA. Genomic sequencing of these samples uncovered two distinctive substitutions in the PB2 (E249G) and NS1 (R21Q) genes which are rare and absent in recent 2024 isolates of H5N1 circulating in the mammalian and avian species. Additionally, approximately 1.7% of the sequence reads indicated a PB2 (E627K) substitution, commonly associated with virus adaptation to mammalian hosts. Phylogenetic analyses of the PB2 and NS genes demonstrated more genetic identity between this environmental isolate and the 2024 human isolate (A/Texas/37/2024) of H5N1. Conversely, HA and NA gene analyses revealed a closer relationship between our isolate and those found in other dairy cattle with almost 100% identity, sharing a common phylogenetic subtree. These findings underscore the rapid evolutionary progression of HPAIV H5N1 among dairy cattle and reinforces the need for more epidemiological monitoring which can be done using environmental sampling. The recent expansion of HPAIV H5N1 infections in terrestrial mammals in the Americas, most recently including the outbreak in dairy cattle, emphasizes the critical need for better epidemiological monitoring of zoonotic diseases. In this work, we detected, isolated, and characterized the HPAIV H5N1 from environmental swab samples collected from a dairy farm in the state of Kansas, USA. Genomic sequencing of these samples uncovered two distinctive substitutions in the PB2 (E249G) and NS1 (R21Q) genes which are rare and absent in recent 2024 isolates of H5N1 circulating in the mammalian and avian species. Additionally, approximately 1.7% of the sequence reads indicated a PB2 (E627K) substitution, commonly associated with virus adaptation to mammalian hosts. Phylogenetic analyses of the PB2 and NS genes demonstrated more genetic identity between this environmental isolate and the 2024 human isolate (A/Texas/37/2024) of H5N1. Conversely, HA and NA gene analyses revealed a closer relationship between our isolate and those found in other dairy cattle with almost 100% identity, sharing a common phylogenetic subtree. These findings underscore the rapid evolutionary progression of HPAIV H5N1 among dairy cattle and reinforces the need for more epidemiological monitoring which can be done using environmental sampling.The recent expansion of HPAIV H5N1 infections in terrestrial mammals in the Americas, most recently including the outbreak in dairy cattle, emphasizes the critical need for better epidemiological monitoring of zoonotic diseases. In this work, we detected, isolated, and characterized the HPAIV H5N1 from environmental swab samples collected from a dairy farm in the state of Kansas, USA. Genomic sequencing of these samples uncovered two distinctive substitutions in the PB2 (E249G) and NS1 (R21Q) genes which are rare and absent in recent 2024 isolates of H5N1 circulating in the mammalian and avian species. Additionally, approximately 1.7% of the sequence reads indicated a PB2 (E627K) substitution, commonly associated with virus adaptation to mammalian hosts. Phylogenetic analyses of the PB2 and NS genes demonstrated more genetic identity between this environmental isolate and the 2024 human isolate (A/Texas/37/2024) of H5N1. Conversely, HA and NA gene analyses revealed a closer relationship between our isolate and those found in other dairy cattle with almost 100% identity, sharing a common phylogenetic subtree. These findings underscore the rapid evolutionary progression of HPAIV H5N1 among dairy cattle and reinforces the need for more epidemiological monitoring which can be done using environmental sampling.
Author	Retallick, Jamie McDowell, Chester D. Matias-Ferreyra, Franco Richt, Juergen A. Noll, Lance Trujillo, Jessie D. Kafle, Sujan Kwon, Taeyong Fitz, Isaac Singh, Gagandeep Gaudreault, Natasha N. Morozov, Igor
AuthorAffiliation	1 Department of Diagnostic Medicine/Pathobiology (DMP), College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA 2 Kansas State Veterinary Diagnostic Laboratory (KSVDL), College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA
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Cites_doi	10.1038/nature05264 10.1126/science.1062882 10.1099/vir.0.80368-0 10.1128/JVI.72.11.8550-8558.1998 10.1128/JVI.05705-11 10.1038/msb.2011.75 10.3201/eid3007.240508 10.1016/S0140-6736(97)11212-0 10.1093/molbev/msab120 10.3201/eid1603.091737 10.4236/cmb.2013.32005 10.1093/bioinformatics/btz305 10.1016/j.jviromet.2022.114454 10.1093/molbev/msy118 10.1007/s007050170002 10.1128/JVI.00296-10 10.2307/1592241 10.1016/j.virol.2003.11.030 10.1016/j.antiviral.2023.105679 10.3390/v11060561 10.1128/jvi.67.4.1761-1764.1993 10.1038/cr.2009.124 10.1099/vir.0.82411-0 10.1016/j.jviromet.2005.08.004 10.3201/eid1206.051336 10.1016/S0042-6822(03)00119-3 10.1101/2023.12.13.571575 10.1101/2024.05.22.595317
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References	Sievers (CR35) 2011; 7 Senne (CR2) 1996; 40 James (CR10) 2022; 301 Uyeki (CR13) 2005 Neumann, Kawaoka (CR17) 2006; 12 Zhou, Wentworth, Kawaoka, Neumann (CR32) 2012 Sponseller (CR9) 2010; 16 CR12 CR34 Russo, Selvatti (CR37) 2018; 35 Hoffmann, Stech, Guan, Webster, Perez (CR33) 2001; 146 Nguyen (CR22) 2023; 217 Ma (CR31) 2011; 85 CR30 Neumann, Chen, Gao, Shu, Kawaoka (CR16) 2010; 20 Puthavathana (CR26) 2005; 86 Burrough (CR14) 2021 Kozlov, Darriba, Flouri, Morel, Stamatakis (CR36) 2019; 35 Shinya (CR28) 2004; 320 Hatta, Gao, Halfmann, Kawaoka (CR25) 2001; 293 CR4 Payungporn (CR11) 2006; 131 CR3 Sreenivasan, Thomas, Kaushik, Wang, Li (CR15) 2019; 11 CR6 CR5 Stoner (CR23) 2010; 84 CR8 Krug, Yuan, Noah, Latham (CR18) 2003; 309 CR7 CR24 Shinya, Watanabe, Ito, Kasai, Kawaoka (CR27) 2007; 88 Subbarao, London, Murphy (CR29) 1993; 67 CR21 Claas (CR1) 1998; 351 Tamura, Stecher, Kumar (CR38) 2021; 38 García-Sastre (CR19) 1998; 72 Yamada (CR20) 2006; 444 G Neumann (2085_CR17) 2006; 12 K Shinya (2085_CR28) 2004; 320 K Shinya (2085_CR27) 2007; 88 F Sievers (2085_CR35) 2011; 7 S Payungporn (2085_CR11) 2006; 131 2085_CR24 E Hoffmann (2085_CR33) 2001; 146 ER Burrough (2085_CR14) 2021 2085_CR21 K Tamura (2085_CR38) 2021; 38 B Zhou (2085_CR32) 2012 P Puthavathana (2085_CR26) 2005; 86 AM Kozlov (2085_CR36) 2019; 35 W Ma (2085_CR31) 2011; 85 HT Nguyen (2085_CR22) 2023; 217 A García-Sastre (2085_CR19) 1998; 72 G Neumann (2085_CR16) 2010; 20 M Hatta (2085_CR25) 2001; 293 EK Subbarao (2085_CR29) 1993; 67 TM Uyeki (2085_CR13) 2005 BA Sponseller (2085_CR9) 2010; 16 CC Sreenivasan (2085_CR15) 2019; 11 EC Claas (2085_CR1) 1998; 351 2085_CR7 2085_CR8 2085_CR12 S Yamada (2085_CR20) 2006; 444 2085_CR34 RM Krug (2085_CR18) 2003; 309 2085_CR3 2085_CR4 2085_CR5 J James (2085_CR10) 2022; 301 TD Stoner (2085_CR23) 2010; 84 2085_CR30 2085_CR6 DA Senne (2085_CR2) 1996; 40 CADM Russo (2085_CR37) 2018; 35
References_xml	– volume: 444 start-page: 378 year: 2006 end-page: 382 ident: CR20 article-title: Haemagglutinin mutations responsible for the binding of H5N1 influenza A viruses to human-type receptors publication-title: Nature doi: 10.1038/nature05264 – volume: 293 start-page: 1840 year: 2001 end-page: 1842 ident: CR25 article-title: Molecular basis for high virulence of Hong Kong H5N1 Influenza A viruses publication-title: Science doi: 10.1126/science.1062882 – ident: CR4 – volume: 86 start-page: 423 year: 2005 end-page: 433 ident: CR26 article-title: Molecular characterization of the complete genome of human influenza H5N1 virus isolates from Thailand publication-title: J. Gen. Virol. doi: 10.1099/vir.0.80368-0 – volume: 72 start-page: 8550 year: 1998 end-page: 8558 ident: CR19 article-title: The role of interferon in Influenza virus tissue tropism publication-title: J Virol doi: 10.1128/JVI.72.11.8550-8558.1998 – ident: CR12 – ident: CR30 – volume: 85 start-page: 11626 year: 2011 end-page: 11637 ident: CR31 article-title: 2009 Pandemic H1N1 influenza virus causes disease and upregulation of genes related to inflammatory and immune responses, cell death, and lipid metabolism in pigs publication-title: J Virol doi: 10.1128/JVI.05705-11 – volume: 7 start-page: 539 year: 2011 ident: CR35 article-title: Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega publication-title: Mol Syst Biol doi: 10.1038/msb.2011.75 – year: 2021 ident: CR14 article-title: Early release—highly pathogenic avian Influenza A(H5N1) Clade 2.3.4.4b virus infection in domestic dairy cattle and cats, United States publication-title: Emerg Infect Dis J doi: 10.3201/eid3007.240508 – volume: 351 start-page: 472 year: 1998 end-page: 477 ident: CR1 article-title: Human influenza A H5N1 virus related to a highly pathogenic avian influenza virus publication-title: Lancet doi: 10.1016/S0140-6736(97)11212-0 – ident: CR6 – volume: 38 start-page: 3022 year: 2021 end-page: 3027 ident: CR38 article-title: MEGA11: molecular evolutionary genetics analysis version 11 publication-title: Mol Biol Evol doi: 10.1093/molbev/msab120 – volume: 16 start-page: 534 year: 2010 end-page: 537 ident: CR9 article-title: Influenza A pandemic (H1N1) 2009 virus infection in domestic cat publication-title: Emerg Infect Dis doi: 10.3201/eid1603.091737 – year: 2005 ident: CR13 article-title: Highly pathogenic avian Influenza A(H5N1) virus infection in a dairy farm worker publication-title: N Engl J Med doi: 10.4236/cmb.2013.32005 – ident: CR8 – volume: 35 start-page: 4453 year: 2019 end-page: 4455 ident: CR36 article-title: RAxML-NG: a fast, scalable and user-friendly tool for maximum likelihood phylogenetic inference publication-title: Bioinformatics doi: 10.1093/bioinformatics/btz305 – volume: 301 start-page: 114454 year: 2022 ident: CR10 article-title: Rapid and sensitive detection of high pathogenicity Eurasian clade 2.3.4.4b avian influenza viruses in wild birds and poultry publication-title: J Virol Methods doi: 10.1016/j.jviromet.2022.114454 – ident: CR21 – volume: 35 start-page: 2327 year: 2018 end-page: 2333 ident: CR37 article-title: Bootstrap and rogue identification tests for phylogenetic analyses publication-title: Mol Biol Evol doi: 10.1093/molbev/msy118 – volume: 146 start-page: 2275 year: 2001 end-page: 2289 ident: CR33 article-title: Universal primer set for the full-length amplification of all influenza A viruses publication-title: Arch Virol doi: 10.1007/s007050170002 – volume: 84 start-page: 9800 year: 2010 end-page: 9809 ident: CR23 article-title: Antiviral susceptibility of avian and swine Influenza virus of the N1 neuraminidase subtype publication-title: J. Virol. doi: 10.1128/JVI.00296-10 – volume: 40 start-page: 425 year: 1996 end-page: 437 ident: CR2 article-title: Survey of the hemagglutinin (HA) cleavage site sequence of H5 and H7 Avian Influenza viruses: amino acid sequence at the HA cleavage site as a marker of pathogenicity potential publication-title: Avian Dis. doi: 10.2307/1592241 – volume: 320 start-page: 258 year: 2004 end-page: 266 ident: CR28 article-title: PB2 amino acid at position 627 affects replicative efficiency, but not cell tropism, of Hong Kong H5N1 influenza A viruses in mice publication-title: Virology doi: 10.1016/j.virol.2003.11.030 – ident: CR3 – volume: 217 start-page: 105679 year: 2023 ident: CR22 article-title: Antiviral susceptibility of clade 2.3.4.4b highly pathogenic avian influenza A(H5N1) viruses isolated from birds and mammals in the United States, 2022 publication-title: Antiviral Res. doi: 10.1016/j.antiviral.2023.105679 – year: 2012 ident: CR32 article-title: Influenza A virus molecular virology techniques publication-title: Influenza virus: methods and protocols – volume: 11 start-page: 561 year: 2019 ident: CR15 article-title: Influenza A in bovine species: a narrative literature review publication-title: Viruses doi: 10.3390/v11060561 – volume: 67 start-page: 1761 year: 1993 end-page: 1764 ident: CR29 article-title: A single amino acid in the PB2 gene of influenza A virus is a determinant of host range publication-title: J Virol doi: 10.1128/jvi.67.4.1761-1764.1993 – volume: 20 start-page: 51 year: 2010 end-page: 61 ident: CR16 article-title: H5N1 influenza viruses: outbreaks and biological properties publication-title: Cell Res. doi: 10.1038/cr.2009.124 – volume: 88 start-page: 547 year: 2007 end-page: 553 ident: CR27 article-title: Adaptation of an H7N7 equine influenza A virus in mice publication-title: J Gen Virol doi: 10.1099/vir.0.82411-0 – volume: 131 start-page: 143 year: 2006 end-page: 147 ident: CR11 article-title: Single step multiplex real-time RT-PCR for H5N1 influenza A virus detection publication-title: J. Virol. Methods doi: 10.1016/j.jviromet.2005.08.004 – ident: CR34 – ident: CR5 – ident: CR7 – ident: CR24 – volume: 12 start-page: 881 year: 2006 end-page: 886 ident: CR17 article-title: Host range restriction and pathogenicity in the context of Influenza pandemic publication-title: Emerg Infect Dis doi: 10.3201/eid1206.051336 – volume: 309 start-page: 181 year: 2003 end-page: 189 ident: CR18 article-title: Intracellular warfare between human influenza viruses and human cells: the roles of the viral NS1 protein publication-title: Virology doi: 10.1016/S0042-6822(03)00119-3 – volume: 72 start-page: 8550 year: 1998 ident: 2085_CR19 publication-title: J Virol doi: 10.1128/JVI.72.11.8550-8558.1998 – volume: 86 start-page: 423 year: 2005 ident: 2085_CR26 publication-title: J. Gen. Virol. doi: 10.1099/vir.0.80368-0 – volume: 20 start-page: 51 year: 2010 ident: 2085_CR16 publication-title: Cell Res. doi: 10.1038/cr.2009.124 – volume: 85 start-page: 11626 year: 2011 ident: 2085_CR31 publication-title: J Virol doi: 10.1128/JVI.05705-11 – volume: 217 start-page: 105679 year: 2023 ident: 2085_CR22 publication-title: Antiviral Res. doi: 10.1016/j.antiviral.2023.105679 – volume: 67 start-page: 1761 year: 1993 ident: 2085_CR29 publication-title: J Virol doi: 10.1128/jvi.67.4.1761-1764.1993 – volume: 351 start-page: 472 year: 1998 ident: 2085_CR1 publication-title: Lancet doi: 10.1016/S0140-6736(97)11212-0 – volume: 38 start-page: 3022 year: 2021 ident: 2085_CR38 publication-title: Mol Biol Evol doi: 10.1093/molbev/msab120 – volume: 7 start-page: 539 year: 2011 ident: 2085_CR35 publication-title: Mol Syst Biol doi: 10.1038/msb.2011.75 – volume: 301 start-page: 114454 year: 2022 ident: 2085_CR10 publication-title: J Virol Methods doi: 10.1016/j.jviromet.2022.114454 – ident: 2085_CR24 – volume: 293 start-page: 1840 year: 2001 ident: 2085_CR25 publication-title: Science doi: 10.1126/science.1062882 – volume: 84 start-page: 9800 year: 2010 ident: 2085_CR23 publication-title: J. Virol. doi: 10.1128/JVI.00296-10 – ident: 2085_CR21 doi: 10.4236/cmb.2013.32005 – volume: 88 start-page: 547 year: 2007 ident: 2085_CR27 publication-title: J Gen Virol doi: 10.1099/vir.0.82411-0 – ident: 2085_CR6 – volume: 131 start-page: 143 year: 2006 ident: 2085_CR11 publication-title: J. Virol. Methods doi: 10.1016/j.jviromet.2005.08.004 – volume-title: Influenza virus: methods and protocols year: 2012 ident: 2085_CR32 – volume: 40 start-page: 425 year: 1996 ident: 2085_CR2 publication-title: Avian Dis. doi: 10.2307/1592241 – ident: 2085_CR34 – year: 2021 ident: 2085_CR14 publication-title: Emerg Infect Dis J doi: 10.3201/eid3007.240508 – volume: 12 start-page: 881 year: 2006 ident: 2085_CR17 publication-title: Emerg Infect Dis doi: 10.3201/eid1206.051336 – ident: 2085_CR4 – volume: 16 start-page: 534 year: 2010 ident: 2085_CR9 publication-title: Emerg Infect Dis doi: 10.3201/eid1603.091737 – ident: 2085_CR30 – volume: 309 start-page: 181 year: 2003 ident: 2085_CR18 publication-title: Virology doi: 10.1016/S0042-6822(03)00119-3 – ident: 2085_CR8 doi: 10.1101/2023.12.13.571575 – volume: 146 start-page: 2275 year: 2001 ident: 2085_CR33 publication-title: Arch Virol doi: 10.1007/s007050170002 – volume: 35 start-page: 4453 year: 2019 ident: 2085_CR36 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btz305 – volume: 444 start-page: 378 year: 2006 ident: 2085_CR20 publication-title: Nature doi: 10.1038/nature05264 – ident: 2085_CR5 – year: 2005 ident: 2085_CR13 publication-title: N Engl J Med doi: 10.4236/cmb.2013.32005 – volume: 11 start-page: 561 year: 2019 ident: 2085_CR15 publication-title: Viruses doi: 10.3390/v11060561 – volume: 35 start-page: 2327 year: 2018 ident: 2085_CR37 publication-title: Mol Biol Evol doi: 10.1093/molbev/msy118 – volume: 320 start-page: 258 year: 2004 ident: 2085_CR28 publication-title: Virology doi: 10.1016/j.virol.2003.11.030 – ident: 2085_CR3 – ident: 2085_CR7 doi: 10.1101/2024.05.22.595317 – ident: 2085_CR12
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Snippet	The recent expansion of HPAIV H5N1 infections in terrestrial mammals in the Americas, most recently including the outbreak in dairy cattle, emphasizes the...
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SubjectTerms	Animals Avian flu Biomedical and Life Sciences Biomedicine birds Cattle Cattle Diseases - epidemiology Cattle Diseases - virology Dairy cattle dairy farming Dairy farms Dairying Environmental monitoring Epidemiology Farms genes Genetic analysis genomics Humans Influenza A Virus, H5N1 Subtype - classification Influenza A Virus, H5N1 Subtype - genetics Influenza A Virus, H5N1 Subtype - isolation & purification Influenza A Virus, H5N1 Subtype - pathogenicity Kansas Medical Microbiology Original Paper Phylogenetics Phylogeny Plant Sciences Rare species species Virology viruses Whole genome sequencing Zoonoses
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Title	Detection and characterization of H5N1 HPAIV in environmental samples from a dairy farm
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