A Test for Creutzfeldt–Jakob Disease Using Nasal Brushings

This preliminary study assessed the accuracy of testing nasal brushings for the prion protein (PrPCJD) found in Creutzfeldt–Jakob disease. In 31 patients with disease and 43 controls, the test had 97% sensitivity and 100% specificity. Prion diseases, or transmissible spongiform encephalopathies, are...

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Vydané v:	The New England journal of medicine Ročník 371; číslo 6; s. 519 - 529
Hlavní autori:	Orrú, Christina D, Bongianni, Matilde, Tonoli, Giovanni, Ferrari, Sergio, Hughson, Andrew G, Groveman, Bradley R, Fiorini, Michele, Pocchiari, Maurizio, Monaco, Salvatore, Caughey, Byron, Zanusso, Gianluigi
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Waltham, MA Massachusetts Medical Society 07.08.2014
Predmet:	Aged Allergies Amyloid Biological and medical sciences Biopsy Brain - pathology Cerebrospinal fluid Creutzfeldt-Jakob disease Creutzfeldt-Jakob Syndrome - diagnosis Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Diagnosis Diagnostic tests Epithelium - chemistry Female Fibrils Fluorescence General aspects Humans Indicator Dilution Techniques Infectious diseases Male Medical sciences Middle Aged Nasal Mucosa - chemistry Neurology Olfactory epithelium Polymerization Prion protein Prions Prions - analysis Prions - cerebrospinal fluid Protein seeding Proteins Seeds Sensitivity and Specificity Italy Infection Medicine Prion disease Nervous system diseases Nose Central nervous system disease Creutzfeldt-Jakob disease Brushing Degenerative disease Nasopharynx Prion Cerebral disorder
ISSN:	0028-4793, 1533-4406, 1533-4406
On-line prístup:	Získať plný text
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