QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies

In 2003, the QUADAS tool for systematic reviews of diagnostic accuracy studies was developed. Experience, anecdotal reports, and feedback suggested areas for improvement; therefore, QUADAS-2 was developed. This tool comprises 4 domains: patient selection, index test, reference standard, and flow and...

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Veröffentlicht in:	Annals of internal medicine Jg. 155; H. 8; S. 529
Hauptverfasser:	Whiting, Penny F, Rutjes, Anne W S, Westwood, Marie E, Mallett, Susan, Deeks, Jonathan J, Reitsma, Johannes B, Leeflang, Mariska M G, Sterne, Jonathan A C, Bossuyt, Patrick M M
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 18.10.2011
Schlagworte:	Bias Diagnosis Evidence-Based Medicine Humans Patient Selection Quality Control Reference Standards Review Literature as Topic Surveys and Questionnaires Time Factors
ISSN:	1539-3704, 1539-3704
Online-Zugang:	Weitere Angaben
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Abstract	In 2003, the QUADAS tool for systematic reviews of diagnostic accuracy studies was developed. Experience, anecdotal reports, and feedback suggested areas for improvement; therefore, QUADAS-2 was developed. This tool comprises 4 domains: patient selection, index test, reference standard, and flow and timing. Each domain is assessed in terms of risk of bias, and the first 3 domains are also assessed in terms of concerns regarding applicability. Signalling questions are included to help judge risk of bias. The QUADAS-2 tool is applied in 4 phases: summarize the review question, tailor the tool and produce review-specific guidance, construct a flow diagram for the primary study, and judge bias and applicability. This tool will allow for more transparent rating of bias and applicability of primary diagnostic accuracy studies.
AbstractList	In 2003, the QUADAS tool for systematic reviews of diagnostic accuracy studies was developed. Experience, anecdotal reports, and feedback suggested areas for improvement; therefore, QUADAS-2 was developed. This tool comprises 4 domains: patient selection, index test, reference standard, and flow and timing. Each domain is assessed in terms of risk of bias, and the first 3 domains are also assessed in terms of concerns regarding applicability. Signalling questions are included to help judge risk of bias. The QUADAS-2 tool is applied in 4 phases: summarize the review question, tailor the tool and produce review-specific guidance, construct a flow diagram for the primary study, and judge bias and applicability. This tool will allow for more transparent rating of bias and applicability of primary diagnostic accuracy studies.In 2003, the QUADAS tool for systematic reviews of diagnostic accuracy studies was developed. Experience, anecdotal reports, and feedback suggested areas for improvement; therefore, QUADAS-2 was developed. This tool comprises 4 domains: patient selection, index test, reference standard, and flow and timing. Each domain is assessed in terms of risk of bias, and the first 3 domains are also assessed in terms of concerns regarding applicability. Signalling questions are included to help judge risk of bias. The QUADAS-2 tool is applied in 4 phases: summarize the review question, tailor the tool and produce review-specific guidance, construct a flow diagram for the primary study, and judge bias and applicability. This tool will allow for more transparent rating of bias and applicability of primary diagnostic accuracy studies. In 2003, the QUADAS tool for systematic reviews of diagnostic accuracy studies was developed. Experience, anecdotal reports, and feedback suggested areas for improvement; therefore, QUADAS-2 was developed. This tool comprises 4 domains: patient selection, index test, reference standard, and flow and timing. Each domain is assessed in terms of risk of bias, and the first 3 domains are also assessed in terms of concerns regarding applicability. Signalling questions are included to help judge risk of bias. The QUADAS-2 tool is applied in 4 phases: summarize the review question, tailor the tool and produce review-specific guidance, construct a flow diagram for the primary study, and judge bias and applicability. This tool will allow for more transparent rating of bias and applicability of primary diagnostic accuracy studies.
Author	Whiting, Penny F Reitsma, Johannes B Leeflang, Mariska M G Rutjes, Anne W S Sterne, Jonathan A C Westwood, Marie E Bossuyt, Patrick M M Mallett, Susan Deeks, Jonathan J
Author_xml	– sequence: 1 givenname: Penny F surname: Whiting fullname: Whiting, Penny F email: penny.whiting@bristol.ac.uk organization: University of Bristol, United Kingdom. penny.whiting@bristol.ac.uk – sequence: 2 givenname: Anne W S surname: Rutjes fullname: Rutjes, Anne W S – sequence: 3 givenname: Marie E surname: Westwood fullname: Westwood, Marie E – sequence: 4 givenname: Susan surname: Mallett fullname: Mallett, Susan – sequence: 5 givenname: Jonathan J surname: Deeks fullname: Deeks, Jonathan J – sequence: 6 givenname: Johannes B surname: Reitsma fullname: Reitsma, Johannes B – sequence: 7 givenname: Mariska M G surname: Leeflang fullname: Leeflang, Mariska M G – sequence: 8 givenname: Jonathan A C surname: Sterne fullname: Sterne, Jonathan A C – sequence: 9 givenname: Patrick M M surname: Bossuyt fullname: Bossuyt, Patrick M M
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/22007046$$D View this record in MEDLINE/PubMed
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ContentType	Journal Article
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References	22351721 - Ann Intern Med. 2012 Feb 21;156(4):323; author reply 323-4. doi: 10.7326/0003-4819-156-4-201202210-00018.
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