Constitutively active Foxo3 in oocytes preserves ovarian reserve in mice

During female reproductive life, ovarian follicle reserve is reduced by maturation and atresia until menopause ensues. Foxo3 is required to maintain the ovarian reserve in mice. Here we show that overexpression of constitutively active FOXO3 can increase ovarian reproductive capacity in mice. We fin...

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Bibliographic Details
Published in:	Nature communications Vol. 4; no. 1; p. 1843
Main Authors:	Pelosi, Emanuele, Omari, Shakib, Michel, Marc, Ding, Jun, Amano, Tomokazu, Forabosco, Antonino, Schlessinger, David, Ottolenghi, Chris
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 2013 Nature Publishing Group
Subjects:	631/443/494 692/698/1460/1527/1710 Aging Animals Female Females Fertility Follicle Stimulating Hormone - blood Forkhead Box Protein O3 Forkhead Transcription Factors - metabolism Gene Expression Profiling Gene Expression Regulation, Developmental Humanities and Social Sciences Humans Luteinizing Hormone - blood Menopause Mice Mice, Knockout multidisciplinary Oligonucleotide Array Sequence Analysis Oocytes - cytology Oocytes - metabolism Ovarian Follicle - growth & development Ovarian Follicle - metabolism Ovary - cytology Ovary - metabolism Science Transgenes
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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