Constitutively active Foxo3 in oocytes preserves ovarian reserve in mice

During female reproductive life, ovarian follicle reserve is reduced by maturation and atresia until menopause ensues. Foxo3 is required to maintain the ovarian reserve in mice. Here we show that overexpression of constitutively active FOXO3 can increase ovarian reproductive capacity in mice. We fin...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	Nature communications Ročník 4; číslo 1; s. 1843
Hlavní autoři:	Pelosi, Emanuele, Omari, Shakib, Michel, Marc, Ding, Jun, Amano, Tomokazu, Forabosco, Antonino, Schlessinger, David, Ottolenghi, Chris
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 2013 Nature Publishing Group
Témata:	631/443/494 692/698/1460/1527/1710 Aging Animals Female Females Fertility Follicle Stimulating Hormone - blood Forkhead Box Protein O3 Forkhead Transcription Factors - metabolism Gene Expression Profiling Gene Expression Regulation, Developmental Humanities and Social Sciences Humans Luteinizing Hormone - blood Menopause Mice Mice, Knockout multidisciplinary Oligonucleotide Array Sequence Analysis Oocytes - cytology Oocytes - metabolism Ovarian Follicle - growth & development Ovarian Follicle - metabolism Ovary - cytology Ovary - metabolism Science Transgenes
ISSN:	2041-1723, 2041-1723
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Buďte první, kdo okomentuje tento záznam!