Constitutively active Foxo3 in oocytes preserves ovarian reserve in mice

During female reproductive life, ovarian follicle reserve is reduced by maturation and atresia until menopause ensues. Foxo3 is required to maintain the ovarian reserve in mice. Here we show that overexpression of constitutively active FOXO3 can increase ovarian reproductive capacity in mice. We fin...

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Published in:	Nature communications Vol. 4; no. 1; p. 1843
Main Authors:	Pelosi, Emanuele, Omari, Shakib, Michel, Marc, Ding, Jun, Amano, Tomokazu, Forabosco, Antonino, Schlessinger, David, Ottolenghi, Chris
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 2013 Nature Publishing Group
Subjects:	631/443/494 692/698/1460/1527/1710 Aging Animals Female Females Fertility Follicle Stimulating Hormone - blood Forkhead Box Protein O3 Forkhead Transcription Factors - metabolism Gene Expression Profiling Gene Expression Regulation, Developmental Humanities and Social Sciences Humans Luteinizing Hormone - blood Menopause Mice Mice, Knockout multidisciplinary Oligonucleotide Array Sequence Analysis Oocytes - cytology Oocytes - metabolism Ovarian Follicle - growth & development Ovarian Follicle - metabolism Ovary - cytology Ovary - metabolism Science Transgenes
ISSN:	2041-1723, 2041-1723
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Abstract	During female reproductive life, ovarian follicle reserve is reduced by maturation and atresia until menopause ensues. Foxo3 is required to maintain the ovarian reserve in mice. Here we show that overexpression of constitutively active FOXO3 can increase ovarian reproductive capacity in mice. We find increased follicle numbers and decreased gonadotropin levels in aging FOXO3 -transgenic mice compared with wild-type littermates, suggesting maintenance of a greater ovarian reserve. Based on cumulative progeny in aging animals, we find 31–49% increased fertility in transgenic females. The gene expression profile of Foxo3−/− knockout ovaries appears older than that of wild-type littermates, and the transgene induces a younger-looking profile, restoring much of the wild-type transcriptome. This is the first gain-of-function model of augmented reproductive reserve in mice, thus emphasizing the role of Foxo3 as a guardian of the ovarian follicle pool in mammals and a potential determinant of the onset of menopause. The number of primordial follicles, which constitute the ovarian reserve, decreases with age. By overexpressing a constitutively active version of the transcription factor FOXO3, the authors increase the ovarian reserve and fertility in aging female mice.
AbstractList	During female reproductive life, ovarian follicle reserve is reduced by maturation and atresia until menopause ensues. Foxo3 is required to maintain the ovarian reserve in mice. Here we show that overexpression of constitutively active FOXO3 can increase ovarian reproductive capacity in mice. We find increased follicle numbers and decreased gonadotropin levels in aging FOXO3 -transgenic mice compared with wild-type littermates, suggesting maintenance of a greater ovarian reserve. Based on cumulative progeny in aging animals, we find 31–49% increased fertility in transgenic females. The gene expression profile of Foxo3−/− knockout ovaries appears older than that of wild-type littermates, and the transgene induces a younger-looking profile, restoring much of the wild-type transcriptome. This is the first gain-of-function model of augmented reproductive reserve in mice, thus emphasizing the role of Foxo3 as a guardian of the ovarian follicle pool in mammals and a potential determinant of the onset of menopause. The number of primordial follicles, which constitute the ovarian reserve, decreases with age. By overexpressing a constitutively active version of the transcription factor FOXO3, the authors increase the ovarian reserve and fertility in aging female mice. During female reproductive life, ovarian follicle reserve is reduced by maturation and atresia until menopause ensues. Foxo3 is required to maintain the ovarian reserve in mice. Here we show that overexpression of constitutively active FOXO3 can increase ovarian reproductive capacity in mice. We find increased follicle numbers and decreased gonadotropin levels in aging FOXO3 transgenic mice compared to wild-type littermates, suggesting maintenance of a greater ovarian reserve. Based on cumulative progeny in aging animals, we find 31 to 49% increased fertility in transgenic females. The gene expression profile of Foxo3−/− knockout ovaries appears more mature than that of wild-type littermates, and the transgene induces a younger-looking profile, restoring much of the wild-type transcriptome. This is the first gain-of-function model of augmented reproductive reserve in mice, thus emphasizing the role of Foxo3 as a guardian of the ovarian follicle pool in mammals and a potential determinant of the onset of menopause. During female reproductive life, ovarian follicle reserve is reduced by maturation and atresia until menopause ensues. Foxo3 is required to maintain the ovarian reserve in mice. Here we show that overexpression of constitutively active FOXO3 can increase ovarian reproductive capacity in mice. We find increased follicle numbers and decreased gonadotropin levels in aging FOXO3-transgenic mice compared with wild-type littermates, suggesting maintenance of a greater ovarian reserve. Based on cumulative progeny in aging animals, we find 31-49% increased fertility in transgenic females. The gene expression profile of Foxo3-/- knockout ovaries appears older than that of wild-type littermates, and the transgene induces a younger-looking profile, restoring much of the wild-type transcriptome. This is the first gain-of-function model of augmented reproductive reserve in mice, thus emphasizing the role of Foxo3 as a guardian of the ovarian follicle pool in mammals and a potential determinant of the onset of menopause.During female reproductive life, ovarian follicle reserve is reduced by maturation and atresia until menopause ensues. Foxo3 is required to maintain the ovarian reserve in mice. Here we show that overexpression of constitutively active FOXO3 can increase ovarian reproductive capacity in mice. We find increased follicle numbers and decreased gonadotropin levels in aging FOXO3-transgenic mice compared with wild-type littermates, suggesting maintenance of a greater ovarian reserve. Based on cumulative progeny in aging animals, we find 31-49% increased fertility in transgenic females. The gene expression profile of Foxo3-/- knockout ovaries appears older than that of wild-type littermates, and the transgene induces a younger-looking profile, restoring much of the wild-type transcriptome. This is the first gain-of-function model of augmented reproductive reserve in mice, thus emphasizing the role of Foxo3 as a guardian of the ovarian follicle pool in mammals and a potential determinant of the onset of menopause. During female reproductive life, ovarian follicle reserve is reduced by maturation and atresia until menopause ensues. Foxo3 is required to maintain the ovarian reserve in mice. Here we show that overexpression of constitutively active FOXO3 can increase ovarian reproductive capacity in mice. We find increased follicle numbers and decreased gonadotropin levels in aging FOXO3-transgenic mice compared with wild-type littermates, suggesting maintenance of a greater ovarian reserve. Based on cumulative progeny in aging animals, we find 31-49% increased fertility in transgenic females. The gene expression profile of Foxo3-/- knockout ovaries appears older than that of wild-type littermates, and the transgene induces a younger-looking profile, restoring much of the wild-type transcriptome. This is the first gain-of-function model of augmented reproductive reserve in mice, thus emphasizing the role of Foxo3 as a guardian of the ovarian follicle pool in mammals and a potential determinant of the onset of menopause.
ArticleNumber	1843
Author	Pelosi, Emanuele Omari, Shakib Amano, Tomokazu Ding, Jun Michel, Marc Schlessinger, David Forabosco, Antonino Ottolenghi, Chris
AuthorAffiliation	2 Genomic Research Center, Cante di Montevecchio Association, via Negusanti, Fano (PU) 61032, Italy 3 Unite’ UMR-S 747 Inserm - University of Paris Descartes, Toxicologie Pharmacologie et Signalisation Cellulaire, 45 rue des Saints Pères, 75270 Paris 06 France 1 Laboratory of Genetics, NIA/NIH-IRP, 251 Bayview blvd, Baltimore MD 21224, USA
AuthorAffiliation_xml	– name: 3 Unite’ UMR-S 747 Inserm - University of Paris Descartes, Toxicologie Pharmacologie et Signalisation Cellulaire, 45 rue des Saints Pères, 75270 Paris 06 France – name: 1 Laboratory of Genetics, NIA/NIH-IRP, 251 Bayview blvd, Baltimore MD 21224, USA – name: 2 Genomic Research Center, Cante di Montevecchio Association, via Negusanti, Fano (PU) 61032, Italy
Author_xml	– sequence: 1 givenname: Emanuele surname: Pelosi fullname: Pelosi, Emanuele email: pelosie@mail.nih.gov organization: Laboratory of Genetics, NIA/NIH-IRP, 251 Bayview blvd, room 10B014, Baltimore, Maryland 21224, USA – sequence: 2 givenname: Shakib surname: Omari fullname: Omari, Shakib organization: Laboratory of Genetics, NIA/NIH-IRP, 251 Bayview blvd, room 10B014, Baltimore, Maryland 21224, USA – sequence: 3 givenname: Marc surname: Michel fullname: Michel, Marc organization: Laboratory of Genetics, NIA/NIH-IRP, 251 Bayview blvd, room 10B014, Baltimore, Maryland 21224, USA – sequence: 4 givenname: Jun surname: Ding fullname: Ding, Jun organization: Laboratory of Genetics, NIA/NIH-IRP, 251 Bayview blvd, room 10B014, Baltimore, Maryland 21224, USA – sequence: 5 givenname: Tomokazu surname: Amano fullname: Amano, Tomokazu organization: Laboratory of Genetics, NIA/NIH-IRP, 251 Bayview blvd, room 10B014, Baltimore, Maryland 21224, USA – sequence: 6 givenname: Antonino surname: Forabosco fullname: Forabosco, Antonino organization: Genomic Research Center, Cante di Montevecchio Association, via Negusanti – sequence: 7 givenname: David surname: Schlessinger fullname: Schlessinger, David organization: Laboratory of Genetics, NIA/NIH-IRP, 251 Bayview blvd, room 10B014, Baltimore, Maryland 21224, USA – sequence: 8 givenname: Chris surname: Ottolenghi fullname: Ottolenghi, Chris organization: Unite’ UMR-S 747 Inserm–University of Paris Descartes, Toxicologie Pharmacologie et Signalisation Cellulaire, 45 rue des Saints Pères, 75270 Paris 06, France
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Cites_doi	10.1242/jcs.001222 10.1038/5985 10.1016/j.exger.2006.05.015 10.1210/endo.141.7.7578 10.1095/biolreprod64.4.1153 10.1210/edrv.19.4.0341 10.1242/dev.02667 10.1093/bioinformatics/btg242 10.1126/science.1086336 10.1101/gad.9.4.455 10.1210/jcem-65-6-1231 10.1093/oxfordjournals.humrep.a137570 10.1210/mend.13.6.0309 10.1073/pnas.0601083103 10.1186/1471-213X-9-36 10.1210/endo-124-2-1000 10.1016/j.ydbio.2008.06.017 10.1016/j.cell.2005.06.031 10.1258/0007142001903445 10.1073/pnas.082099299 10.1002/ajmg.10565 10.1038/ncb1869 10.1016/S0925-4773(98)00161-0 10.1016/j.fertnstert.2006.11.191 10.1016/j.ydbio.2005.08.023 10.1534/genetics.107.074823 10.1242/dev.110.4.1057
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References	Schlessinger (CR4) 2002; 111 Pangas (CR17) 2006; 103 Arden (CR8) 2006; 41 Perez (CR27) 1999; 21 Cole, Galic, Zack (CR28) 2003; 19 Bedell (CR16) 1995; 9 Johnson (CR20) 2005; 122 Tibshirani, Hastie, Narasimhan, Chu (CR29) 2002; 99 Huang, Tindall (CR9) 2007; 120 Zou (CR21) 2009; 11 Elvin (CR12) 1999; 13 Forabosco, Sforza (CR2) 2007; 88 Gallardo (CR19) 2007; 177 Prior (CR11) 1998; 19 Pan, O'Brien, Wigglesworth, Eppig, Schultz (CR25) 2005; 286 McGee, Hsueh (CR1) 2000; 21 Castrillon, Miao, Kollipara, Horner, DePinho (CR6) 2003; 301 John, Gallardo, Shirley, Castrillon (CR7) 2008; 321 Britt (CR15) 2000; 141 Garcia-Ortiz (CR18) 2009; 9 Flaws, Hirshfield, Hewitt, Babus, Furth (CR26) 2001; 64 Conway (CR5) 2000; 56 Laitinen (CR13) 1998; 78 Liu (CR23) 2007; 134 Richardson, Senikas, Nelson (CR22) 1987; 65 Ueno, Takahashi, Manganaro, Ragin, Donahoe (CR14) 1989; 124 Manova, Nocka, Besmer, Bachvarova (CR10) 1990; 110 Faddy (CR3) 1992; 7 Kinloch, Wassarman (CR24) 1989; 1 MA Bedell (BFncomms2861_CR16) 1995; 9 R Tibshirani (BFncomms2861_CR29) 2002; 99 M Faddy (BFncomms2861_CR3) 1992; 7 KC Arden (BFncomms2861_CR8) 2006; 41 S Ueno (BFncomms2861_CR14) 1989; 124 H Pan (BFncomms2861_CR25) 2005; 286 M Laitinen (BFncomms2861_CR13) 1998; 78 GS Conway (BFncomms2861_CR5) 2000; 56 K Zou (BFncomms2861_CR21) 2009; 11 K Manova (BFncomms2861_CR10) 1990; 110 EA McGee (BFncomms2861_CR1) 2000; 21 RA Kinloch (BFncomms2861_CR24) 1989; 1 TD Gallardo (BFncomms2861_CR19) 2007; 177 SW Cole (BFncomms2861_CR28) 2003; 19 D Schlessinger (BFncomms2861_CR4) 2002; 111 J Johnson (BFncomms2861_CR20) 2005; 122 KL Britt (BFncomms2861_CR15) 2000; 141 GI Perez (BFncomms2861_CR27) 1999; 21 SA Pangas (BFncomms2861_CR17) 2006; 103 L Liu (BFncomms2861_CR23) 2007; 134 GB John (BFncomms2861_CR7) 2008; 321 DH Castrillon (BFncomms2861_CR6) 2003; 301 SJ Richardson (BFncomms2861_CR22) 1987; 65 A Forabosco (BFncomms2861_CR2) 2007; 88 JA Flaws (BFncomms2861_CR26) 2001; 64 JE Garcia-Ortiz (BFncomms2861_CR18) 2009; 9 JC Prior (BFncomms2861_CR11) 1998; 19 JA Elvin (BFncomms2861_CR12) 1999; 13 H Huang (BFncomms2861_CR9) 2007; 120
References_xml	– volume: 120 start-page: 2479 year: 2007 end-page: 2487 ident: CR9 article-title: Dynamic FoxO transcription factors publication-title: J. Cell Sci. doi: 10.1242/jcs.001222 – volume: 21 start-page: 200 year: 1999 end-page: 203 ident: CR27 article-title: Prolongation of ovarian lifespan into advanced chronological age by Bax-deficiency publication-title: Nat. Genet. doi: 10.1038/5985 – volume: 41 start-page: 709 year: 2006 end-page: 717 ident: CR8 article-title: Multiple roles of FOXO transcription factors in mammalian cells point to multiple roles in cancer publication-title: Exp. Gerontol. doi: 10.1016/j.exger.2006.05.015 – volume: 141 start-page: 2614 year: 2000 end-page: 2623 ident: CR15 article-title: An age-related ovarian phenotype in mice with targeted disruption of the Cyp 19 (aromatase) gene publication-title: Endocrinology doi: 10.1210/endo.141.7.7578 – volume: 64 start-page: 1153 year: 2001 end-page: 1159 ident: CR26 article-title: Effect of bcl-2 on the primordial follicle endowment in the mouse ovary publication-title: Biol. Reprod. doi: 10.1095/biolreprod64.4.1153 – volume: 21 start-page: 200 year: 2000 end-page: 214 ident: CR1 article-title: Initial and cyclic recruitment of ovarian follicles publication-title: Endocr. Rev. – volume: 19 start-page: 397 year: 1998 end-page: 428 ident: CR11 article-title: Perimenopause: the complex endocrinology of the menopausal transition publication-title: Endocr. Rev. doi: 10.1210/edrv.19.4.0341 – volume: 134 start-page: 199 year: 2007 end-page: 209 ident: CR23 article-title: Infertility caused by retardation of follicular development in mice with oocyte-specific expression of Foxo3a publication-title: Development doi: 10.1242/dev.02667 – volume: 19 start-page: 1808 year: 2003 end-page: 1816 ident: CR28 article-title: Controlling false-negative errors in microarray differential expression analysis: a PRIM approach publication-title: Bioinformatics doi: 10.1093/bioinformatics/btg242 – volume: 301 start-page: 215 year: 2003 end-page: 218 ident: CR6 article-title: Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a publication-title: Science doi: 10.1126/science.1086336 – volume: 9 start-page: 455 year: 1995 end-page: 470 ident: CR16 article-title: DNA rearrangements located over 100 kb 5’ of the Steel (Sl)-coding region in Steel-panda and Steel-contrasted mice deregulate Sl expression and cause female sterility by disrupting ovarian follicle development publication-title: Genes Dev. doi: 10.1101/gad.9.4.455 – volume: 65 start-page: 1231 year: 1987 end-page: 1237 ident: CR22 article-title: Follicular depletion during the menopausal transition: evidence for accelerated loss and ultimate exhaustion publication-title: J. Clin. Endocrinol. Metab. doi: 10.1210/jcem-65-6-1231 – volume: 7 start-page: 1342 year: 1992 end-page: 1346 ident: CR3 article-title: Accelerated disappearance of ovarian follicles in mid-life: implications for forecasting menopause publication-title: Hum. Reprod. doi: 10.1093/oxfordjournals.humrep.a137570 – volume: 13 start-page: 1018 year: 1999 end-page: 1034 ident: CR12 article-title: Molecular characterization of the follicle defects in the growth differentiation factor 9-deficient ovary publication-title: Mol. Endocrinol. doi: 10.1210/mend.13.6.0309 – volume: 103 start-page: 8090 year: 2006 end-page: 8095 ident: CR17 article-title: Oogenesis requires germ cell-specific transcriptional regulators Sohlh1 and Lhx8 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.0601083103 – volume: 9 start-page: 36 year: 2009 ident: CR18 article-title: functions in sex determination and histogenesis throughout mouse ovary development publication-title: BMC Dev. Biol. doi: 10.1186/1471-213X-9-36 – volume: 124 start-page: 1000 year: 1989 end-page: 1006 ident: CR14 article-title: Cellular localization of mullerian inhibiting substance in the developing rat ovary publication-title: Endocrinology doi: 10.1210/endo-124-2-1000 – volume: 321 start-page: 197 year: 2008 end-page: 204 ident: CR7 article-title: Foxo3 is a PI3K-dependent molecular switch controlling the initiation of oocyte growth publication-title: Dev. Biol. doi: 10.1016/j.ydbio.2008.06.017 – volume: 122 start-page: 303 year: 2005 end-page: 315 ident: CR20 article-title: Oocyte generation in adult mammalian ovaries by putative germ cells in bone marrow and peripheral blood publication-title: Cell doi: 10.1016/j.cell.2005.06.031 – volume: 1 start-page: 232 year: 1989 end-page: 238 ident: CR24 article-title: Profile of mammalian sperm receptor gene publication-title: New. Biol. – volume: 56 start-page: 643 year: 2000 end-page: 649 ident: CR5 article-title: Premature ovarian failure publication-title: Br. Med. Bull. doi: 10.1258/0007142001903445 – volume: 99 start-page: 6567 year: 2002 end-page: 6572 ident: CR29 article-title: Diagnosis of multiple cancer types by shrunken centroids of gene expression publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.082099299 – volume: 111 start-page: 328 year: 2002 end-page: 333 ident: CR4 article-title: Genes and translocations involved in POF publication-title: Am. J. Med. Genet. doi: 10.1002/ajmg.10565 – volume: 110 start-page: 1057 year: 1990 end-page: 1069 ident: CR10 article-title: Gonadal expression of encoded at the locus of the mouse publication-title: Development – volume: 11 start-page: 631 year: 2009 end-page: 636 ident: CR21 article-title: Production of offspring from a germline stem cell line derived from neonatal ovaries publication-title: Nat. Cell. Biol. doi: 10.1038/ncb1869 – volume: 78 start-page: 135 year: 1998 end-page: 140 ident: CR13 article-title: A novel growht differentiation factor-9 (GDF-9) related factor is coexpressed with GDF-9 in Mouse oocytes during folliculogenesis publication-title: Mech. Dev. doi: 10.1016/S0925-4773(98)00161-0 – volume: 88 start-page: 675 year: 2007 end-page: 683 ident: CR2 article-title: Establishment of ovarian reserve: a quantitative morphometric study of the developing human ovary publication-title: Fertil. Steril. doi: 10.1016/j.fertnstert.2006.11.191 – volume: 286 start-page: 493 year: 2005 end-page: 506 ident: CR25 article-title: Transcript profiling during mouse oocyte development and the effect of gonadotropin priming and development in vitro publication-title: Dev. Biol. doi: 10.1016/j.ydbio.2005.08.023 – volume: 177 start-page: 179 year: 2007 end-page: 194 ident: CR19 article-title: Genomewide discovery and classification of candidate ovarian fertility genes in the mouse publication-title: Genetics doi: 10.1534/genetics.107.074823 – volume: 141 start-page: 2614 year: 2000 ident: BFncomms2861_CR15 publication-title: Endocrinology doi: 10.1210/endo.141.7.7578 – volume: 301 start-page: 215 year: 2003 ident: BFncomms2861_CR6 publication-title: Science doi: 10.1126/science.1086336 – volume: 99 start-page: 6567 year: 2002 ident: BFncomms2861_CR29 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.082099299 – volume: 122 start-page: 303 year: 2005 ident: BFncomms2861_CR20 publication-title: Cell doi: 10.1016/j.cell.2005.06.031 – volume: 124 start-page: 1000 year: 1989 ident: BFncomms2861_CR14 publication-title: Endocrinology doi: 10.1210/endo-124-2-1000 – volume: 19 start-page: 397 year: 1998 ident: BFncomms2861_CR11 publication-title: Endocr. Rev. doi: 10.1210/edrv.19.4.0341 – volume: 111 start-page: 328 year: 2002 ident: BFncomms2861_CR4 publication-title: Am. J. Med. Genet. doi: 10.1002/ajmg.10565 – volume: 321 start-page: 197 year: 2008 ident: BFncomms2861_CR7 publication-title: Dev. Biol. doi: 10.1016/j.ydbio.2008.06.017 – volume: 177 start-page: 179 year: 2007 ident: BFncomms2861_CR19 publication-title: Genetics doi: 10.1534/genetics.107.074823 – volume: 286 start-page: 493 year: 2005 ident: BFncomms2861_CR25 publication-title: Dev. Biol. doi: 10.1016/j.ydbio.2005.08.023 – volume: 64 start-page: 1153 year: 2001 ident: BFncomms2861_CR26 publication-title: Biol. Reprod. doi: 10.1095/biolreprod64.4.1153 – volume: 21 start-page: 200 year: 1999 ident: BFncomms2861_CR27 publication-title: Nat. Genet. doi: 10.1038/5985 – volume: 110 start-page: 1057 year: 1990 ident: BFncomms2861_CR10 publication-title: Development doi: 10.1242/dev.110.4.1057 – volume: 13 start-page: 1018 year: 1999 ident: BFncomms2861_CR12 publication-title: Mol. Endocrinol. doi: 10.1210/mend.13.6.0309 – volume: 9 start-page: 36 year: 2009 ident: BFncomms2861_CR18 publication-title: BMC Dev. Biol. doi: 10.1186/1471-213X-9-36 – volume: 78 start-page: 135 year: 1998 ident: BFncomms2861_CR13 publication-title: Mech. Dev. doi: 10.1016/S0925-4773(98)00161-0 – volume: 134 start-page: 199 year: 2007 ident: BFncomms2861_CR23 publication-title: Development doi: 10.1242/dev.02667 – volume: 1 start-page: 232 year: 1989 ident: BFncomms2861_CR24 publication-title: New. Biol. – volume: 41 start-page: 709 year: 2006 ident: BFncomms2861_CR8 publication-title: Exp. Gerontol. doi: 10.1016/j.exger.2006.05.015 – volume: 88 start-page: 675 year: 2007 ident: BFncomms2861_CR2 publication-title: Fertil. Steril. doi: 10.1016/j.fertnstert.2006.11.191 – volume: 11 start-page: 631 year: 2009 ident: BFncomms2861_CR21 publication-title: Nat. Cell. Biol. doi: 10.1038/ncb1869 – volume: 21 start-page: 200 year: 2000 ident: BFncomms2861_CR1 publication-title: Endocr. Rev. – volume: 65 start-page: 1231 year: 1987 ident: BFncomms2861_CR22 publication-title: J. Clin. Endocrinol. Metab. doi: 10.1210/jcem-65-6-1231 – volume: 120 start-page: 2479 year: 2007 ident: BFncomms2861_CR9 publication-title: J. Cell Sci. doi: 10.1242/jcs.001222 – volume: 56 start-page: 643 year: 2000 ident: BFncomms2861_CR5 publication-title: Br. Med. Bull. doi: 10.1258/0007142001903445 – volume: 7 start-page: 1342 year: 1992 ident: BFncomms2861_CR3 publication-title: Hum. Reprod. doi: 10.1093/oxfordjournals.humrep.a137570 – volume: 103 start-page: 8090 year: 2006 ident: BFncomms2861_CR17 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.0601083103 – volume: 19 start-page: 1808 year: 2003 ident: BFncomms2861_CR28 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btg242 – volume: 9 start-page: 455 year: 1995 ident: BFncomms2861_CR16 publication-title: Genes Dev. doi: 10.1101/gad.9.4.455
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Snippet	During female reproductive life, ovarian follicle reserve is reduced by maturation and atresia until menopause ensues. Foxo3 is required to maintain the...
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SubjectTerms	631/443/494 692/698/1460/1527/1710 Aging Animals Female Females Fertility Follicle Stimulating Hormone - blood Forkhead Box Protein O3 Forkhead Transcription Factors - metabolism Gene Expression Profiling Gene Expression Regulation, Developmental Humanities and Social Sciences Humans Luteinizing Hormone - blood Menopause Mice Mice, Knockout multidisciplinary Oligonucleotide Array Sequence Analysis Oocytes - cytology Oocytes - metabolism Ovarian Follicle - growth & development Ovarian Follicle - metabolism Ovary - cytology Ovary - metabolism Science Transgenes
Title	Constitutively active Foxo3 in oocytes preserves ovarian reserve in mice
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