Skeletal Muscle Deconditioning in Breast Cancer Patients Undergoing Chemotherapy: Current Knowledge and Insights From Other Cancers

Breast cancer represents the most commonly diagnosed cancer while neoadjuvant and adjuvant chemotherapies are extensively used in order to reduce tumor development and improve disease-free survival. However, chemotherapy also leads to severe off-target side-effects resulting, together with the tumor...

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Vydáno v:Frontiers in cell and developmental biology Ročník 9; s. 719643
Hlavní autoři: Mallard, Joris, Hucteau, Elyse, Hureau, Thomas J., Pagano, Allan F.
Médium: Journal Article
Jazyk:angličtina
Vydáno: Frontiers Media S.A 14.09.2021
Témata:
cancer cachexia
Cell and Developmental Biology
inflammatory cytokines
intermuscular adipose tissue
mitochondria
muscle atrophy
protein turnover
ISSN:2296-634X, 2296-634X
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Abstract Breast cancer represents the most commonly diagnosed cancer while neoadjuvant and adjuvant chemotherapies are extensively used in order to reduce tumor development and improve disease-free survival. However, chemotherapy also leads to severe off-target side-effects resulting, together with the tumor itself, in major skeletal muscle deconditioning. This review first focuses on recent advances in both macroscopic changes and cellular mechanisms implicated in skeletal muscle deconditioning of breast cancer patients, particularly as a consequence of the chemotherapy treatment. To date, only six clinical studies used muscle biopsies in breast cancer patients and highlighted several important aspects of muscle deconditioning such as a decrease in muscle fibers cross-sectional area, a dysregulation of protein turnover balance and mitochondrial alterations. However, in comparison with the knowledge accumulated through decades of intensive research with many different animal and human models of muscle atrophy, more studies are necessary to obtain a comprehensive understanding of the cellular processes implicated in breast cancer-mediated muscle deconditioning. This understanding is indeed essential to ultimately lead to the implementation of efficient preventive strategies such as exercise, nutrition or pharmacological treatments. We therefore also discuss potential mechanisms implicated in muscle deconditioning by drawing a parallel with other cancer cachexia models of muscle wasting, both at the pre-clinical and clinical levels.
AbstractList Breast cancer represents the most commonly diagnosed cancer while neoadjuvant and adjuvant chemotherapies are extensively used in order to reduce tumor development and improve disease-free survival. However, chemotherapy also leads to severe off-target side-effects resulting, together with the tumor itself, in major skeletal muscle deconditioning. This review first focuses on recent advances in both macroscopic changes and cellular mechanisms implicated in skeletal muscle deconditioning of breast cancer patients, particularly as a consequence of the chemotherapy treatment. To date, only six clinical studies used muscle biopsies in breast cancer patients and highlighted several important aspects of muscle deconditioning such as a decrease in muscle fibers cross-sectional area, a dysregulation of protein turnover balance and mitochondrial alterations. However, in comparison with the knowledge accumulated through decades of intensive research with many different animal and human models of muscle atrophy, more studies are necessary to obtain a comprehensive understanding of the cellular processes implicated in breast cancer-mediated muscle deconditioning. This understanding is indeed essential to ultimately lead to the implementation of efficient preventive strategies such as exercise, nutrition or pharmacological treatments. We therefore also discuss potential mechanisms implicated in muscle deconditioning by drawing a parallel with other cancer cachexia models of muscle wasting, both at the pre-clinical and clinical levels.
Breast cancer represents the most commonly diagnosed cancer while neoadjuvant and adjuvant chemotherapies are extensively used in order to reduce tumor development and improve disease-free survival. However, chemotherapy also leads to severe off-target side-effects resulting, together with the tumor itself, in major skeletal muscle deconditioning. This review first focuses on recent advances in both macroscopic changes and cellular mechanisms implicated in skeletal muscle deconditioning of breast cancer patients, particularly as a consequence of the chemotherapy treatment. To date, only six clinical studies used muscle biopsies in breast cancer patients and highlighted several important aspects of muscle deconditioning such as a decrease in muscle fibers cross-sectional area, a dysregulation of protein turnover balance and mitochondrial alterations. However, in comparison with the knowledge accumulated through decades of intensive research with many different animal and human models of muscle atrophy, more studies are necessary to obtain a comprehensive understanding of the cellular processes implicated in breast cancer-mediated muscle deconditioning. This understanding is indeed essential to ultimately lead to the implementation of efficient preventive strategies such as exercise, nutrition or pharmacological treatments. We therefore also discuss potential mechanisms implicated in muscle deconditioning by drawing a parallel with other cancer cachexia models of muscle wasting, both at the pre-clinical and clinical levels.Breast cancer represents the most commonly diagnosed cancer while neoadjuvant and adjuvant chemotherapies are extensively used in order to reduce tumor development and improve disease-free survival. However, chemotherapy also leads to severe off-target side-effects resulting, together with the tumor itself, in major skeletal muscle deconditioning. This review first focuses on recent advances in both macroscopic changes and cellular mechanisms implicated in skeletal muscle deconditioning of breast cancer patients, particularly as a consequence of the chemotherapy treatment. To date, only six clinical studies used muscle biopsies in breast cancer patients and highlighted several important aspects of muscle deconditioning such as a decrease in muscle fibers cross-sectional area, a dysregulation of protein turnover balance and mitochondrial alterations. However, in comparison with the knowledge accumulated through decades of intensive research with many different animal and human models of muscle atrophy, more studies are necessary to obtain a comprehensive understanding of the cellular processes implicated in breast cancer-mediated muscle deconditioning. This understanding is indeed essential to ultimately lead to the implementation of efficient preventive strategies such as exercise, nutrition or pharmacological treatments. We therefore also discuss potential mechanisms implicated in muscle deconditioning by drawing a parallel with other cancer cachexia models of muscle wasting, both at the pre-clinical and clinical levels.
Author Hucteau, Elyse
Pagano, Allan F.
Mallard, Joris
Hureau, Thomas J.
AuthorAffiliation 3 Faculté des Sciences du Sport, Centre Européen d’Enseignement de Recherche et d’Innovation en Physiologie de l’Exercice (CEERIPE), Université de Strasbourg , Strasbourg , France
1 Institut de Cancérologie Strasbourg Europe (ICANS) , Strasbourg , France
2 Centre de Recherche en Biomédecine de Strasbourg (CRBS), Fédération de Médecine Translationnelle, UR 3072, Université de Strasbourg , Strasbourg , France
AuthorAffiliation_xml – name: 3 Faculté des Sciences du Sport, Centre Européen d’Enseignement de Recherche et d’Innovation en Physiologie de l’Exercice (CEERIPE), Université de Strasbourg , Strasbourg , France
– name: 1 Institut de Cancérologie Strasbourg Europe (ICANS) , Strasbourg , France
– name: 2 Centre de Recherche en Biomédecine de Strasbourg (CRBS), Fédération de Médecine Translationnelle, UR 3072, Université de Strasbourg , Strasbourg , France
Author_xml – sequence: 1
  givenname: Joris
  surname: Mallard
  fullname: Mallard, Joris
– sequence: 2
  givenname: Elyse
  surname: Hucteau
  fullname: Hucteau, Elyse
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  givenname: Thomas J.
  surname: Hureau
  fullname: Hureau, Thomas J.
– sequence: 4
  givenname: Allan F.
  surname: Pagano
  fullname: Pagano, Allan F.
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Cites_doi 10.1038/s41580-020-0230-3
10.1038/nrdp.2017.105
10.1016/S0039-6060(99)70131-5
10.1038/sj.gt.3303016
10.1016/j.lungcan.2011.09.012
10.1016/j.critrevonc.2018.06.011
10.1002/jcsm.12138
10.2174/156800909789057015
10.1038/sj.sc.3101968
10.1111/j.1582-4934.2009.00864.x
10.5301/tj.5000393
10.1016/j.breast.2018.04.009
10.3390/ijerph18052591
10.1002/jmri.23512
10.1016/j.lungcan.2011.10.009
10.1038/srep26991
10.1038/s41467-020-20123-1
10.1179/016164110X12556180205997
10.1038/s41556-018-0151-y
10.1016/j.ejca.2009.10.008
10.1007/s10863-017-9718-8
10.1139/apnm-2019-0352
10.1155/2016/6729268
10.1186/s40959-019-0038-5
10.1016/j.cell.2004.09.027
10.1007/s13539-014-0137-y
10.1007/s00520-012-1600-y
10.2522/ptj.20100329
10.1186/s12885-019-5448-0
10.1002/(SICI)1097-0185(20000301)258:3<305::AID-AR10>3.0.CO;2-A
10.1096/fj.201600250RR
10.3945/ajcn.2009.28047
10.1002/mus.23753
10.1016/j.bbagen.2012.11.009
10.3389/fphys.2019.01074
10.1096/fj.13-240580
10.1007/s00520-012-1697-z
10.1002/jcsm.12232
10.1152/japplphysiol.00210.2014
10.1113/jphysiol.2012.230185
10.1002/jcsm.12539
10.1152/ajpcell.00002.2018
10.1101/gad.412606
10.1007/s004410000280
10.1002/jcsm.12259
10.3389/fonc.2020.01304
10.1016/j.clnesp.2021.02.007
10.1016/j.bbrc.2009.12.123
10.1096/fj.201800683RR
10.1016/j.clnu.2007.06.005
10.3389/fcell.2021.636498
10.1111/apha.12263
10.1249/MSS.0000000000001916
10.1038/srep30340
10.3322/caac.21660
10.1002/rco2.23
10.1038/s41598-019-46178-9
10.3389/fphys.2019.00041
10.1007/s10549-018-4663-8
10.3892/or_00000328
10.33549/physiolres.931272
10.1016/j.freeradbiomed.2014.11.006
10.18632/oncotarget.9779
10.1002/jcsm.12461
10.1158/1535-7163.MCT-16-0324
10.1158/1078-0432.CCR-18-1565
10.1096/fj.201700968R
10.1002/jcsm.12265
10.1080/01635581.2018.1502330
10.1002/jcsm.12165
10.1101/gad.276733.115
10.1016/j.ajpath.2012.12.023
10.1002/jcsm.12618
10.1152/ajpregu.00716.2007
10.1007/s10549-017-4574-0
10.1038/srep32695
10.1249/MSS.0000000000001970
10.1242/dmm.010389
10.1016/j.biochi.2018.04.009
10.3945/ajcn.112.047860
10.1186/s13395-019-0193-2
10.1016/s0021-9290(02)00418-9
10.1186/2044-5040-2-14
10.1016/j.jss.2016.06.076
10.1097/01.SLA.0000055225.96357.71
10.1186/1471-2407-12-265
10.1016/j.nut.2019.03.012
10.1371/journal.pone.0083618
10.3892/ijo.2018.4661
10.1161/JAHA.113.000432
10.1007/s10549-020-05624-3
10.1016/j.exger.2005.04.003
10.1007/s00018-014-1689-x
10.1002/jcsm.12267
10.3945/ajcn.113.058388
10.1080/15548627.2020.1797280
10.1007/s10585-006-9010-5
10.3322/caac.21268
10.1016/j.biocel.2013.06.011
10.1073/pnas.251541198
10.1200/JCO.2014.59.1081
10.1096/fj.201801862R
10.1152/physrev.00061.2017
10.3892/or.2019.7205
10.3389/fphys.2014.00068
10.1152/ajpendo.00257.2016
10.1111/febs.12253
10.1016/j.critrevonc.2019.102839
10.1038/nrc3829
10.1097/MCO.0000000000000048
10.1152/jappl.1961.16.6.977
10.1111/apha.12224
10.1002/jcsm.12489
10.1002/mus.21945
10.1371/journal.pone.0024650
10.1152/japplphysiol.00355.2011
10.3390/ijms22052567
10.1038/sj.bjc.6601981
10.1016/S1470-2045(10)70218-7
10.1002/path.4801
10.2174/2211738507666190122111224
10.1083/jcb.9.2.493
10.1016/j.exger.2016.10.003
10.3390/cancers11091264
10.1007/s10549-019-05303-y
10.1007/s004240050392
10.1113/jphysiol.2014.286518
10.1038/srep08717
10.1152/japplphysiol.00778.2005
10.1038/bjc.1993.126
10.1001/jamaoncol.2018.0137
10.1172/JCI116897
10.1002/jcsm.12633
10.1152/ajpcell.00344.2015
10.1002/jcsm.12528
10.1002/jcsm.12104
10.3389/fphys.2021.673404
10.1016/j.freeradbiomed.2016.02.021
10.17987/jcsm-cr.v2i1.26
10.1093/ajcn/nqz347
10.3390/ijerph17197289
10.1007/s00520-010-0832-y
10.1007/s10549-019-05352-3
10.1136/bmj.289.6445.584
10.1371/journal.pone.0013604
10.1016/j.febslet.2004.05.066
10.4048/jbc.2020.23.e8
10.1186/s12885-017-3116-9
10.3892/ijmm.2010.557
10.3892/ijmm.8.3.279
10.3390/nu11112724
10.1002/jcp.24611
10.4081/ejtm.2018.7590
10.1172/JCI68523
10.1046/j.1532-5415.2002.50217.x
10.1249/MSS.0000000000002260
10.1096/fj.03-0610com
10.1002/jcsm.12642
10.3892/ijo.2013.1998
10.1242/jcs.086629
10.1634/theoncologist.2017-0672
10.1371/journal.pone.0205467
10.1152/ajpendo.1995.268.5.E996
10.1371/journal.pone.0181086
10.1007/s00421-020-04556-6
10.1007/s00520-017-3902-6
10.1054/bjoc.2001.1700
10.1186/s12967-016-1003-9
10.1002/jcsm.12310
10.18632/oncotarget.17387
10.1007/s00520-016-3402-0
10.1111/j.1349-7006.2001.tb01141.x
10.3390/antiox10040588
10.1016/j.chest.2019.10.014
10.1111/apha.13400
10.1152/jappl.2001.90.6.2157
10.1016/j.biocel.2004.10.017
10.1111/acel.12399
10.1158/1078-0432.CCR-07-1147
10.14814/phy2.14052
10.1007/s00432-019-02911-5
10.1007/s13539-011-0049-z
10.1074/jbc.M115.641514
10.1152/ajpregu.00299.2019
10.1152/japplphysiol.00429.2011
10.1152/ajpregu.2001.281.1.R133
10.1101/2020.04.05.026617
10.1152/ajpcell.00217.2011
10.1210/jc.2014-4318
10.18632/oncotarget.24680
10.3389/fphys.2013.00284
10.1152/physiol.00041.2007
10.1158/0008-5472.CAN-14-0057
10.1016/0022-510x(88)90132-3
10.1002/jcsm.12294
10.1155/2014/309570
10.1002/jcsm.12498
10.1016/j.cllc.2016.06.003
10.1016/j.bbrc.2018.01.092
10.1123/japa.2015-0056
10.1200/JCO.2014.56.1894
10.1093/ajcn/85.2.377
10.3390/biom9110735
10.1002/(SICI)1097-0142(19980101)82:1<42::AID-CNCR5>3.0.CO;2-M
10.1016/j.tips.2015.03.005
10.1158/0008-5472.CAN-15-3152
10.1200/JCO.2020.38.15_suppl.e24069
10.18632/oncotarget.9958
10.1172/jci.insight.125543
10.1002/jcsm.12007
10.1158/1078-0432.CCR-07-1033
10.1245/s10434-011-1720-5
10.1093/annonc/mdx809
10.1152/ajpendo.00540.2015
10.1139/apnm-2018-0473
10.1002/jcsm.12311
10.3390/ijms21134759
10.1007/s10974-019-09510-4
10.1001/jamaoncol.2019.4668
10.1002/ijc.29930
10.3109/00365517509095787
10.1016/j.cell.2015.08.031
10.1038/cddis.2014.161
10.1634/theoncologist.2016-0066
10.1111/j.1749-6632.2000.tb06416.x
10.1093/ajcn/79.5.874
10.3389/fphar.2017.00137
10.1002/14651858.CD004421.pub3
10.1371/journal.pone.0030348
10.1007/s12603-010-0081-2
10.1016/j.biocel.2013.04.014
10.1093/icvts/ivz313
10.3389/fnut.2020.00004
10.1158/1078-0432.CCR-16-2266
10.3389/fphys.2018.00167
10.1097/00000441-193211000-00002
10.1016/j.ccr.2005.10.004
10.2214/AJR.07.2732
10.1038/bjc.1996.294
10.1128/MCB.00184-19
10.1016/s0024-3205(03)00566-6
10.1016/j.jmb.2019.05.032
10.1016/j.suc.2013.01.006
10.1111/j.1365-2362.2008.01970.x
10.1016/j.bbrc.2013.05.018
10.18632/aging.100436
10.1152/ajpcell.00069.2010
10.6004/jnccn.2020.7554
10.1007/s00520-020-05858-3
10.1002/ijc.29620
10.1038/s41598-017-13504-y
10.3389/fphys.2014.00503
10.3390/ijms21207704
10.1002/jcsm.12209
10.1007/s00109-007-0177-2
10.1152/jappl.1997.83.6.1857
10.1016/j.molmet.2020.101046
10.2337/dc14-1585
10.1038/s41598-017-15040-1
10.1038/ijo.2009.170
10.1007/s00330-020-06799-5
10.3390/cancers13081806
10.3892/ol.2011.442
10.3892/or.2018.6453
10.1152/japplphysiol.00203.2020
10.1002/jcp.25851
10.1016/j.jep.2019.112222
10.1016/j.mam.2016.04.006
10.1113/expphysiol.2013.072496
10.1249/MSS.0000000000001790
10.26355/eurrev_201804_14752
10.1056/NEJM200109273451312
10.1093/gerona/60.3.324
10.1002/jcsm.12043
10.1007/s13539-012-0071-9
10.1186/s13395-016-0098-2
10.3389/fphys.2020.00071
10.1634/theoncologist.2019-0777
10.1111/cas.14520
10.1016/j.freeradbiomed.2013.08.191
10.1016/j.cell.2010.07.011
10.1002/mus.26061
10.1002/jcsm.12107
10.1158/1078-0432.CCR-16-3001
10.1001/jamacardio.2019.5586
10.1371/journal.pone.0200936
10.1093/ageing/afy169
10.1093/jncics/pky043
10.1002/(SICI)1097-4598(199811)21:11<1457::AID-MUS14>3.0.CO;2-Y
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Reviewed by: Paola Costelli, University of Turin, Italy; Bert Blaauw, University of Padua, Italy; Amélie Rébillard, Laboratoire des Sciences du Mouvement, du Sport et de la Santé (M2S), France
Edited by: Yann Simon Gallot, University of Évry Val d’Essonne, France
This article was submitted to Signaling, a section of the journal Frontiers in Cell and Developmental Biology
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  year: 2021
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  day: 14
PublicationDecade 2020
PublicationTitle Frontiers in cell and developmental biology
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Publisher Frontiers Media S.A
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References Huot (B127) 2020; 11
Fermoselle (B95) 2013; 98
Allen (B9) 1997; 83
Khal (B145) 2005; 37
Bonetto (B45) 2009; 9
Shah (B242) 2018; 23
Larsson (B151) 2019; 99
De Groef (B82) 2018; 40
Ferreira (B96) 2008; 57
McLean (B175) 2014; 5
Gilliam (B109) 2016; 311
Skorokhod (B249) 2012; 12
Wallengren (B279) 2013; 21
Gadéa (B102) 2018; 70
Liu (B160) 2019; 9
Sies (B244) 2020; 21
Smith (B251) 2000; 302
Schumacher (B237) 2019; 51
Smith (B250) 2004; 91
Rutten (B226) 2016; 7
Aleixo (B8) 2019; 177
Sirago (B247) 2017; 7
Rier (B219) 2016; 21
Chopard (B69) 2009; 13
Costelli (B73) 1993; 92
Gorgey (B114) 2007; 45
Wesolowski (B282) 2020; 30
Salazar-Degracia (B229) 2018; 149
Coletti (B70) 2016; 2016
Caan (B56) 2018; 4
Keenan (B144) 2020; 18
Acharyya (B1) 2005; 8
Loumaye (B162) 2015; 100
Nissinen (B191) 2016; 6
Martin (B169) 2015; 33
Penna (B204) 2013; 182
Yildiz Kabak (B291) 2020; 29
Biferali (B38) 2019; 10
Chen (B67) 2018; 40
Cho (B68) 2018; 13
Chacon-Cabrera (B61) 2017; 232
Barreto (B27) 2016; 7
Chacon-Cabrera (B60) 2014; 229
Schirrmacher (B234) 2019; 54
Tuttle (B267) 2011; 91
Galiano-Castillo (B103) 2016; 24
Inaba (B130) 2018; 13
Powers (B209) 2016; 98
Redden (B215) 2013; 93
Schmidt (B235) 2015; 35
Samuels (B230) 2001; 281
Jerusalem (B132) 2019; 177
Baracos (B24) 1995; 268
Matsuyama (B172) 2015; 137
Sun (B258) 2016; 311
Barreto (B26) 2017; 7
Borisov (B46) 2000; 258
Baracos (B25) 2018; 4
Wiederin (B285) 2020; 38
Op den Kamp (B196) 2013; 98
Costelli (B74) 2008; 38
Andrianjafiniony (B10) 2010; 299
Goodpaster (B113) 2000; 904
Leskinen (B155) 2009; 33
Madaro (B164) 2018; 20
Bae (B20) 2020; 246
Bodine (B40) 2013; 45
Arc-Chagnaud (B12) 2020; 11
Murton (B186) 2017; 18
Temparis (B261) 1994; 54
Petruzzelli (B205) 2016; 30
Smith (B252) 1993; 67
Straughn (B257) 2021; 9
Puig-Vilanova (B210) 2015; 79
Julienne (B139) 2012; 3
Chen (B66) 2016; 7
CeŠeiko (B58) 2020; 52
Gilliam (B108) 2013; 65
White (B283) 2011; 6
Fouladiun (B100) 2007; 13
Busquets (B53); 3
Judge (B138) 2018; 2
Bonaldo (B44) 2013; 6
Wren (B290) 2008; 190
Jubrias (B137) 1997; 434
Aggarwal (B4) 2019; 9
Lønbro (B161) 2017; 2
D’Lugos (B78) 2019; 7
Hulmi (B125) 2018; 9
Hesse (B122) 2019; 5
Gomes (B111) 2001; 98
Aversa (B19) 2016; 6
Damrauer (B80) 2018; 28
de Lima Junior (B83) 2016; 7
Enright (B93) 2003; 48
Uezumi (B271) 2011; 124
Baldwin (B21) 2013; 4
Penna (B201); 10
Puppa (B211) 2014; 28
Crouch (B75) 2017; 12
Ahmadabadi (B5) 2020; 45
Zhang (B296) 2020; 111
Huh (B124) 2020; 23
Wilson (B289) 2020
Wang (B280) 2021; 4
Kunzke (B149) 2020; 11
Ballarò (B22) 2019; 33
Tsang (B266) 2003; 73
Silva (B246) 2020; 11
Guo (B118) 2017; 8
Vainshtein (B274) 2020; 21
Kavazis (B141) 2014; 117
Nissinen (B192) 2018; 9
Cruz-Jentoft (B77) 2019; 48
Trestini (B265) 2018; 129
Lecker (B152) 2004; 18
Hiensch (B123) 2019; 229
Pigna (B207) 2016; 6
Williams (B286) 1999; 126
Beck (B30) 1991; 51
Chen (B64) 2019; 42
Ushmorov (B273) 1999; 59
Fearon (B94) 2011; 12
Zhong (B297) 2019; 10
Mallard (B165) 2020; 10
Shachar (B241) 2017; 23
Antoun (B11) 2018; 29
Dupont-Versteegden (B89) 2005; 40
Roberts (B221) 2013; 435
Brown (B51) 2017; 8
Maughan (B173) 2010; 81
Klassen (B147) 2017; 8
Chen (B63) 2016; 76
Bohlen (B41) 2018; 9
Cheema (B62) 2015; 14
Fisusi (B98) 2019; 7
Neyroud (B189) 2019; 40
Busquets (B54); 3
Emens (B91) 2018; 24
Nicolazzi (B190) 2018; 22
Ramos da Silva (B213) 2021; 42
Agarwala (B3) 2020; 157
Jones (B136) 2012; 76
Gallot (B107) 2014; 74
Ieronimakis (B129) 2016; 240
Mason (B171) 2016; 205
Dolly (B88) 2020; 11
Baltgalvis (B23) 2008; 294
Uezumi (B269); 5
Hatakeyama (B120) 2016; 6
Goodpaster (B112) 2001; 90
Padrão (B197) 2013; 45
Aleixo (B6); 181
Aleixo (B7); 145
Theret (B262) 2021; 12
Bennegård (B33) 1984; 44
Gilliam (B110) 2012; 302
Willson (B287) 2019; 9
Sandri (B231) 2008; 23
Schiaffino (B233) 2013; 280
Cespedes Feliciano (B59) 2019; 6
Guigni (B116) 2018; 315
Bregni (B49) 2016; 102
Kazemi-Bajestani (B143) 2014; 5
Bossola (B47) 2003; 237
Uezumi (B270); 5
Peel (B199) 2014; 3
Penna (B200) 2014; 17
Ishiko (B131) 2001; 8
He (B121) 2013; 123
Tarnopolsky (B260) 2011; 43
di Prampero (B87) 2003; 36
Mauro (B174) 1961; 9
Song (B254) 2004; 79
Bird (B39) 2008; 14
Berger (B35) 2015; 65
Rodriguez (B223) 2014; 71
Bergstrom (B36) 1975; 35
Johns (B134) 2017; 8
Johns (B133) 2014; 9
Levolger (B157) 2019; 9
Hyatt (B128) 2021; 10
Mijwel (B178); 169
Marzetti (B170) 2017; 87
Sorensen (B255) 2017; 8
Marcus (B167) 2010; 14
Addison (B2) 2014; 2014
Karampinos (B140) 2012; 35
Penna (B202); 431
Ryan (B227) 2018; 496
Penna (B203) 2010; 5
Pagano (B198) 2018; 9
Leto (B156) 2006; 23
Rhoads (B217) 2010; 46
Moore-Carrasco (B183) 2007; 30
Murphy (B185) 2011; 112
Quan-Jun (B212) 2017; 16
Busquets (B52) 2007; 26
Costamagna (B72) 2020; 11
Johnston (B135) 2015; 162
Scott (B240) 1996; 73
Loumaye (B163) 2017; 8
Warren (B281) 1932; 184
Benny Klimek (B34) 2010; 391
Zou (B299) 2017; 49
Tzika (B268) 2013; 43
Visser (B278) 2002; 50
Delmonico (B85) 2009; 90
van Waart (B275) 2015; 33
Urbina-Varela (B272) 2020; 21
Min (B180) 2015; 593
Bohnert (B43) 2019; 39
Beavers (B29) 2013; 97
Astrand (B15) 1961; 16
Roeland (B224) 2017; 25
Larsen (B150) 2012; 590
Deluche (B86) 2018; 26
Rochette (B222) 2015; 36
Riccardi (B218) 2020; 7
Gallagher (B104) 2014; 37
Schmitt (B236) 2007; 85
Stock (B256) 2021; 121
Lexell (B158) 1988; 84
Daly (B79) 2018; 9
Pin (B208) 2018; 9
Rossi (B225) 2020; 30
Møller (B181) 2019; 145
But-Hadzic (B55) 2021; 18
Schwarz (B238) 2017; 17
Neil (B188) 2013; 21
Visser (B277) 2005; 60
Klionsky (B148) 2021; 17
Mijwel (B179); 32
Chen (B65) 2018; 9
Bohnert (B42) 2016; 30
Yu (B294) 2014; 211
Aubrey (B17) 2014; 210
Guo (B117) 2012; 7
Zhou (B298) 2010; 142
Mehl (B177) 2005; 99
Skipworth (B248) 2011; 19
Figueras (B97) 2004; 569
Lee (B153) 2021; 13
Ranjbar (B214) 2019; 51
White (B284) 2012; 2
Bernardo (B37) 2020; 11
Wilson (B288) 2019; 25
McLoon (B176) 1998; 21
Behr (B31) 2001; 345
Hulmi (B126) 2020; 41
Smuder (B253) 2011; 111
Aversa (B18) 2012; 19
Shum (B243) 2012; 4
Reding (B216) 2019; 5
Silva (B245) 2015; 290
Cruz (B76) 2019; 19
de Castro (B81) 2019; 11
Gallot (B105) 2021; 22
Constantinou (B71) 2011; 27
Hanson (B119) 2013; 48
Manini (B166) 2007; 85
Bowen (B48) 2015; 6
Liu (B159) 2008; 15
Op den Kamp (B195) 2012; 76
Beaudry (B28) 2020; 25
Foulkes (B101) 2019; 51
Dworzak (B90) 1998; 82
Lee (B154) 2019; 11
Montalvo (B182) 2020; 318
Brioche (B50) 2016; 50
Varricchi (B276) 2018; 9
Yoshida (B292) 2001; 92
Zampieri (B295) 2010; 32
Ojima (B193) 2020; 111
Schwarzkopf (B239) 2006; 20
Argilés (B14) 2019; 66
(B187) 2019
Atherton (B16) 2016; 311
Salazar-Degracia (B228) 2016; 14
Sartori (B232) 2021; 12
Belizário (B32) 2001; 84
DeJong (B84) 2005; 14
Kawanishi (B142) 2018; 57
Cai (B57) 2004; 119
Yu (B293) 2020; 5
Marques (B168) 2020; 17
Rier (B220) 2018; 168
Gallot (B106) 2019; 33
Argilés (B13) 2014; 14
Fontes-Oliveira (B99) 2013; 1830
Gouspillou (B115) 2015; 5
Toledo (B263) 2016; 138
Op den Kamp (B194) 2015; 6
Toth (B264) 2020; 128
Pettersen (B206) 2020; 11
Khan (B146) 2019; 44
Sung (B259) 2021; 71
Emery (B92) 1984; 289
Moses (B184) 2009; 21
References_xml – volume: 21
  start-page: 363
  year: 2020
  ident: B244
  article-title: Reactive oxygen species (ROS) as pleiotropic physiological signalling agents.
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/s41580-020-0230-3
– volume: 4
  year: 2018
  ident: B25
  article-title: Cancer-associated cachexia.
  publication-title: Nat. Rev. Dis. Primers
  doi: 10.1038/nrdp.2017.105
– volume: 126
  start-page: 744
  year: 1999
  ident: B286
  article-title: The expression of genes in the ubiquitin-proteasome proteolytic pathway is increased in skeletal muscle from patients with cancer.
  publication-title: Surgery
  doi: 10.1016/S0039-6060(99)70131-5
– volume: 15
  start-page: 155
  year: 2008
  ident: B159
  article-title: Myostatin antisense RNA-mediated muscle growth in normal and cancer cachexia mice.
  publication-title: Gene Ther.
  doi: 10.1038/sj.gt.3303016
– volume: 76
  start-page: 112
  year: 2012
  ident: B195
  article-title: Pre-cachexia in patients with stages I–III non-small cell lung cancer: systemic inflammation and functional impairment without activation of skeletal muscle ubiquitin proteasome system.
  publication-title: Lung Cancer
  doi: 10.1016/j.lungcan.2011.09.012
– volume: 129
  start-page: 54
  year: 2018
  ident: B265
  article-title: Clinical implication of changes in body composition and weight in patients with early-stage and metastatic breast cancer.
  publication-title: Crit. Rev. Oncol. Hematol.
  doi: 10.1016/j.critrevonc.2018.06.011
– volume: 8
  start-page: 122
  year: 2017
  ident: B134
  article-title: New genetic signatures associated with cancer cachexia as defined by low skeletal muscle index and weight loss.
  publication-title: J. Cachexia Sarcopenia Muscle
  doi: 10.1002/jcsm.12138
– volume: 9
  start-page: 608
  year: 2009
  ident: B45
  article-title: Deacetylase inhibitors modulate the myostatin/follistatin axis without improving cachexia in tumor-bearing mice.
  publication-title: Curr. Cancer Drug Targets
  doi: 10.2174/156800909789057015
– volume: 45
  start-page: 304
  year: 2007
  ident: B114
  article-title: Skeletal muscle atrophy and increased intramuscular fat after incomplete spinal cord injury.
  publication-title: Spinal Cord
  doi: 10.1038/sj.sc.3101968
– volume: 13
  start-page: 3032
  year: 2009
  ident: B69
  article-title: Molecular events and signalling pathways involved in skeletal muscle disuse-induced atrophy and the impact of countermeasures.
  publication-title: J. Cell. Mol. Med.
  doi: 10.1111/j.1582-4934.2009.00864.x
– volume: 102
  start-page: 1
  year: 2016
  ident: B49
  article-title: Trastuzumab cardiac toxicity: a problem we put our heart into.
  publication-title: Tumori
  doi: 10.5301/tj.5000393
– volume: 40
  start-page: 23
  year: 2018
  ident: B82
  article-title: Physical activity levels after treatment for breast cancer: two-year follow-up.
  publication-title: Breast Edinb. Scotl.
  doi: 10.1016/j.breast.2018.04.009
– volume: 18
  year: 2021
  ident: B55
  article-title: Six-Minute walk distance in breast cancer survivors-a systematic review with meta-analysis.
  publication-title: Int. J. Environ. Res. Public. Health
  doi: 10.3390/ijerph18052591
– volume: 35
  start-page: 899
  year: 2012
  ident: B140
  article-title: Characterization of the regional distribution of skeletal muscle adipose tissue in type 2 diabetes using chemical shift-based water/fat separation.
  publication-title: J. Magn. Reson. Imaging JMRI
  doi: 10.1002/jmri.23512
– volume: 76
  start-page: 248
  year: 2012
  ident: B136
  article-title: Prognostic significance of functional capacity and exercise behavior in patients with metastatic non-small cell lung cancer.
  publication-title: Lung Cancer
  doi: 10.1016/j.lungcan.2011.10.009
– volume: 6
  year: 2016
  ident: B207
  article-title: Aerobic exercise and pharmacological treatments counteract cachexia by modulating autophagy in colon cancer.
  publication-title: Sci. Rep.
  doi: 10.1038/srep26991
– volume: 12
  year: 2021
  ident: B232
  article-title: Mechanisms of muscle atrophy and hypertrophy: implications in health and disease.
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-020-20123-1
– volume: 32
  start-page: 20
  year: 2010
  ident: B295
  article-title: Subclinical myopathy in patients affected with newly diagnosed colorectal cancer at clinical onset of disease: evidence from skeletal muscle biopsies.
  publication-title: Neurol. Res.
  doi: 10.1179/016164110X12556180205997
– volume: 20
  start-page: 917
  year: 2018
  ident: B164
  article-title: Denervation-activated STAT3-IL-6 signalling in fibro-adipogenic progenitors promotes myofibres atrophy and fibrosis.
  publication-title: Nat. Cell Biol.
  doi: 10.1038/s41556-018-0151-y
– volume: 46
  start-page: 191
  year: 2010
  ident: B217
  article-title: Expression of NF-kappaB and IkappaB proteins in skeletal muscle of gastric cancer patients.
  publication-title: Eur. J. Cancer Oxf. Engl. 1990
  doi: 10.1016/j.ejca.2009.10.008
– volume: 49
  start-page: 325
  year: 2017
  ident: B299
  article-title: Manganese superoxide dismutase (SOD2): is there a center in the universe of mitochondrial redox signaling?
  publication-title: J. Bioenerg. Biomembr.
  doi: 10.1007/s10863-017-9718-8
– volume: 45
  start-page: 555
  year: 2020
  ident: B5
  article-title: The effects of high-intensity interval training and saffron aqueous extract supplementation on alterations of body weight and apoptotic indices in skeletal muscle of 4T1 breast cancer-bearing mice with cachexia.
  publication-title: Appl. Physiol. Nutr. Metab. Physiol. Appl. Nutr. Metab.
  doi: 10.1139/apnm-2019-0352
– volume: 2016
  year: 2016
  ident: B70
  article-title: Spontaneous physical activity downregulates Pax7 in cancer cachexia.
  publication-title: Stem Cells Int.
  doi: 10.1155/2016/6729268
– volume: 5
  year: 2019
  ident: B216
  article-title: Increased skeletal intermuscular fat is associated with reduced exercise capacity in cancer survivors: a cross-sectional study.
  publication-title: Cardio Oncol.
  doi: 10.1186/s40959-019-0038-5
– volume: 119
  start-page: 285
  year: 2004
  ident: B57
  article-title: IKKbeta/NF-kappaB activation causes severe muscle wasting in mice.
  publication-title: Cell
  doi: 10.1016/j.cell.2004.09.027
– volume: 5
  start-page: 95
  year: 2014
  ident: B143
  article-title: Concurrent evolution of cancer cachexia and heart failure: bilateral effects exist.
  publication-title: J. Cachexia Sarcopenia Muscle
  doi: 10.1007/s13539-014-0137-y
– volume: 21
  start-page: 873
  year: 2013
  ident: B188
  article-title: Cardiorespiratory and neuromuscular deconditioning in fatigued and non-fatigued breast cancer survivors.
  publication-title: Support. Care Cancer Off. J. Multinatl. Assoc. Support. Care Cancer
  doi: 10.1007/s00520-012-1600-y
– volume: 91
  start-page: 923
  year: 2011
  ident: B267
  article-title: Lower physical activity is associated with higher intermuscular adipose tissue in people with type 2 diabetes and peripheral neuropathy.
  publication-title: Phys. Ther.
  doi: 10.2522/ptj.20100329
– volume: 19
  year: 2019
  ident: B76
  article-title: A leucine-rich diet modulates the mTOR cell signalling pathway in the gastrocnemius muscle under different Walker-256 tumour growth conditions.
  publication-title: BMC Cancer
  doi: 10.1186/s12885-019-5448-0
– volume: 258
  start-page: 305
  year: 2000
  ident: B46
  article-title: Cell death in denervated skeletal muscle is distinct from classical apoptosis.
  publication-title: Anat. Rec.
  doi: 10.1002/(SICI)1097-0185(20000301)258:3<305::AID-AR10>3.0.CO;2-A
– volume: 30
  start-page: 3053
  year: 2016
  ident: B42
  article-title: Inhibition of ER stress and unfolding protein response pathways causes skeletal muscle wasting during cancer cachexia.
  publication-title: FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol.
  doi: 10.1096/fj.201600250RR
– volume: 90
  start-page: 1579
  year: 2009
  ident: B85
  article-title: Longitudinal study of muscle strength, quality, and adipose tissue infiltration.
  publication-title: Am. J. Clin. Nutr.
  doi: 10.3945/ajcn.2009.28047
– volume: 48
  start-page: 393
  year: 2013
  ident: B119
  article-title: Longitudinal characterization of functional, morphologic, and biochemical adaptations in mouse skeletal muscle with hindlimb suspension.
  publication-title: Muscle Nerve
  doi: 10.1002/mus.23753
– volume: 1830
  start-page: 2770
  year: 2013
  ident: B99
  article-title: Mitochondrial and sarcoplasmic reticulum abnormalities in cancer cachexia: altered energetic efficiency?
  publication-title: Biochim. Biophys. Acta
  doi: 10.1016/j.bbagen.2012.11.009
– volume: 10
  year: 2019
  ident: B38
  article-title: Fibro-Adipogenic progenitors cross-talk in skeletal muscle: the social network.
  publication-title: Front. Physiol.
  doi: 10.3389/fphys.2019.01074
– volume: 28
  start-page: 998
  year: 2014
  ident: B211
  article-title: Skeletal muscle glycoprotein 130’s role in Lewis lung carcinoma-induced cachexia.
  publication-title: FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol.
  doi: 10.1096/fj.13-240580
– volume: 21
  start-page: 1569
  year: 2013
  ident: B279
  article-title: Diagnostic criteria of cancer cachexia: relation to quality of life, exercise capacity and survival in unselected palliative care patients.
  publication-title: Support. Care Cancer Off. J. Multinatl. Assoc. Support. Care Cancer
  doi: 10.1007/s00520-012-1697-z
– volume: 8
  start-page: 926
  year: 2017
  ident: B51
  article-title: Mitochondrial degeneration precedes the development of muscle atrophy in progression of cancer cachexia in tumour-bearing mice.
  publication-title: J. Cachexia Sarcopenia Muscle
  doi: 10.1002/jcsm.12232
– volume: 117
  start-page: 223
  year: 2014
  ident: B141
  article-title: Effects of short-term endurance exercise training on acute doxorubicin-induced FoxO transcription in cardiac and skeletal muscle.
  publication-title: J. Appl. Physiol. Bethesda Md 1985
  doi: 10.1152/japplphysiol.00210.2014
– volume: 590
  start-page: 3349
  year: 2012
  ident: B150
  article-title: Biomarkers of mitochondrial content in skeletal muscle of healthy young human subjects.
  publication-title: J. Physiol.
  doi: 10.1113/jphysiol.2012.230185
– volume: 11
  start-page: 783
  year: 2020
  ident: B72
  article-title: Interleukin-4 administration improves muscle function, adult myogenesis, and lifespan of colon carcinoma-bearing mice.
  publication-title: J. Cachexia Sarcopenia Muscle
  doi: 10.1002/jcsm.12539
– volume: 315
  start-page: C744
  year: 2018
  ident: B116
  article-title: Skeletal muscle atrophy and dysfunction in breast cancer patients: role for chemotherapy-derived oxidant stress.
  publication-title: Am. J. Physiol. Cell Physiol.
  doi: 10.1152/ajpcell.00002.2018
– volume: 20
  start-page: 3440
  year: 2006
  ident: B239
  article-title: Muscle cachexia is regulated by a p53–PW1/Peg3-dependent pathway.
  publication-title: Genes Dev.
  doi: 10.1101/gad.412606
– volume: 302
  start-page: 235
  year: 2000
  ident: B251
  article-title: Nuclear DNA fragmentation and morphological alterations in adult rabbit skeletal muscle after short-term immobilization.
  publication-title: Cell Tissue Res.
  doi: 10.1007/s004410000280
– volume: 9
  start-page: 335
  year: 2018
  ident: B198
  article-title: Short-term disuse promotes fatty acid infiltration into skeletal muscle.
  publication-title: J. Cachexia Sarcopenia Muscle
  doi: 10.1002/jcsm.12259
– volume: 10
  year: 2020
  ident: B165
  article-title: Evolution of physical status from diagnosis to the end of first-line treatment in breast, lung, and colorectal cancer patients: the PROTECT-01 cohort study protocol.
  publication-title: Front. Oncol.
  doi: 10.3389/fonc.2020.01304
– volume: 42
  start-page: 105
  year: 2021
  ident: B213
  article-title: Performance of functionality measures and phase angle in women exposed to chemotherapy for early breast cancer.
  publication-title: Clin. Nutr. ESPEN
  doi: 10.1016/j.clnesp.2021.02.007
– volume: 391
  start-page: 1548
  year: 2010
  ident: B34
  article-title: Acute inhibition of myostatin-family proteins preserves skeletal muscle in mouse models of cancer cachexia.
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2009.12.123
– volume: 33
  start-page: 1946
  year: 2019
  ident: B106
  article-title: PERK regulates skeletal muscle mass and contractile function in adult mice.
  publication-title: FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol.
  doi: 10.1096/fj.201800683RR
– volume: 26
  start-page: 614
  year: 2007
  ident: B52
  article-title: Apoptosis is present in skeletal muscle of cachectic gastro-intestinal cancer patients.
  publication-title: Clin. Nutr. Edinb. Scotl.
  doi: 10.1016/j.clnu.2007.06.005
– volume: 59
  start-page: 3527
  year: 1999
  ident: B273
  article-title: Differential reconstitution of mitochondrial respiratory chain activity and plasma redox state by cysteine and ornithine in a model of cancer cachexia.
  publication-title: Cancer Res.
– volume: 9
  year: 2021
  ident: B257
  article-title: Withaferin a and ovarian cancer antagonistically regulate skeletal muscle mass.
  publication-title: Front. Cell Dev. Biol.
  doi: 10.3389/fcell.2021.636498
– volume: 211
  start-page: 201
  year: 2014
  ident: B294
  article-title: Acylated and unacylated ghrelin inhibit doxorubicin-induced apoptosis in skeletal muscle.
  publication-title: Acta Physiol. Oxf. Engl.
  doi: 10.1111/apha.12263
– volume: 51
  start-page: 1387
  year: 2019
  ident: B214
  article-title: Combined exercise training positively affects muscle wasting in tumor-bearing mice.
  publication-title: Med. Sci. Sports Exerc.
  doi: 10.1249/MSS.0000000000001916
– volume: 6
  year: 2016
  ident: B19
  article-title: Autophagy is induced in the skeletal muscle of cachectic cancer patients.
  publication-title: Sci. Rep.
  doi: 10.1038/srep30340
– volume: 71
  start-page: 209
  year: 2021
  ident: B259
  article-title: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.
  publication-title: CA. Cancer J. Clin.
  doi: 10.3322/caac.21660
– volume: 4
  start-page: 24
  year: 2021
  ident: B280
  article-title: Aging-associated skeletal muscle defects in HER2/Neu transgenic mammary tumor model.
  publication-title: JCSM Rapid Commun.
  doi: 10.1002/rco2.23
– volume: 9
  year: 2019
  ident: B157
  article-title: Inhibition of activin-like kinase 4/5 attenuates cancer cachexia associated muscle wasting.
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-019-46178-9
– year: 2019
  ident: B187
  publication-title: Cancer Stat Facts: Female Breast Cancer.
– volume: 10
  ident: B201
  article-title: The skeletal muscle as an active player against cancer cachexia.
  publication-title: Front. Physiol.
  doi: 10.3389/fphys.2019.00041
– volume: 169
  start-page: 93
  ident: B178
  article-title: Highly favorable physiological responses to concurrent resistance and high-intensity interval training during chemotherapy: the OptiTrain breast cancer trial.
  publication-title: Breast Cancer Res. Treat.
  doi: 10.1007/s10549-018-4663-8
– volume: 21
  start-page: 1091
  year: 2009
  ident: B184
  article-title: Pro-inflammatory cytokine release by peripheral blood mononuclear cells from patients with advanced pancreatic cancer: relationship to acute phase response and survival.
  publication-title: Oncol. Rep.
  doi: 10.3892/or_00000328
– volume: 57
  start-page: 601
  year: 2008
  ident: B96
  article-title: Evidences of apoptosis during the early phases of soleus muscle atrophy in hindlimb suspended mice.
  publication-title: Physiol. Res.
  doi: 10.33549/physiolres.931272
– volume: 79
  start-page: 91
  year: 2015
  ident: B210
  article-title: Oxidative stress, redox signaling pathways, and autophagy in cachectic muscles of male patients with advanced COPD and lung cancer.
  publication-title: Free Radic. Biol. Med.
  doi: 10.1016/j.freeradbiomed.2014.11.006
– volume: 7
  start-page: 43442
  year: 2016
  ident: B27
  article-title: Chemotherapy-related cachexia is associated with mitochondrial depletion and the activation of ERK1/2 and p38 MAPKs.
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.9779
– volume: 10
  start-page: 1083
  year: 2019
  ident: B297
  article-title: The systemic activin response to pancreatic cancer: implications for effective cancer cachexia therapy.
  publication-title: J. Cachexia Sarcopenia Muscle
  doi: 10.1002/jcsm.12461
– volume: 16
  start-page: 334
  year: 2017
  ident: B212
  article-title: Selumetinib attenuates skeletal muscle wasting in murine cachexia model through ERK inhibition and AKT activation.
  publication-title: Mol. Cancer Ther.
  doi: 10.1158/1535-7163.MCT-16-0324
– volume: 25
  start-page: 2336
  year: 2019
  ident: B288
  article-title: Human breast cancer Xenograft model implicates peroxisome proliferator-activated receptor signaling as driver of cancer-induced muscle fatigue.
  publication-title: Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res.
  doi: 10.1158/1078-0432.CCR-18-1565
– volume: 32
  start-page: 5495
  ident: B179
  article-title: Exercise training during chemotherapy preserves skeletal muscle fiber area, capillarization, and mitochondrial content in patients with breast cancer.
  publication-title: FASEB J.
  doi: 10.1096/fj.201700968R
– volume: 9
  start-page: 417
  year: 2018
  ident: B125
  article-title: Prevention of chemotherapy-induced cachexia by ACVR2B ligand blocking has different effects on heart and skeletal muscle.
  publication-title: J. Cachexia Sarcopenia Muscle
  doi: 10.1002/jcsm.12265
– volume: 70
  start-page: 997
  year: 2018
  ident: B102
  article-title: Prospective study on body composition, energy balance and biological factors changes in post-menopausal women with breast cancer receiving adjuvant chemotherapy including taxanes.
  publication-title: Nutr. Cancer
  doi: 10.1080/01635581.2018.1502330
– volume: 8
  start-page: 305
  year: 2017
  ident: B147
  article-title: Muscle strength in breast cancer patients receiving different treatment regimes.
  publication-title: J. Cachexia Sarcopenia Muscle
  doi: 10.1002/jcsm.12165
– volume: 30
  start-page: 489
  year: 2016
  ident: B205
  article-title: Mechanisms of metabolic dysfunction in cancer-associated cachexia.
  publication-title: Genes Dev.
  doi: 10.1101/gad.276733.115
– volume: 182
  start-page: 1367
  year: 2013
  ident: B204
  article-title: Autophagic degradation contributes to muscle wasting in cancer cachexia.
  publication-title: Am. J. Pathol.
  doi: 10.1016/j.ajpath.2012.12.023
– volume: 11
  start-page: 1813
  year: 2020
  ident: B37
  article-title: Characterization of cachexia in the human fibrosarcoma HT-1080 mouse tumour model.
  publication-title: J. Cachexia Sarcopenia Muscle
  doi: 10.1002/jcsm.12618
– volume: 294
  start-page: R393
  year: 2008
  ident: B23
  article-title: Interleukin-6 and cachexia in ApcMin/+ mice.
  publication-title: Am. J. Physiol. Regul. Integr. Comp. Physiol.
  doi: 10.1152/ajpregu.00716.2007
– volume: 168
  start-page: 95
  year: 2018
  ident: B220
  article-title: Changes in body composition and muscle attenuation during taxane-based chemotherapy in patients with metastatic breast cancer.
  publication-title: Breast Cancer Res. Treat.
  doi: 10.1007/s10549-017-4574-0
– volume: 6
  year: 2016
  ident: B191
  article-title: Systemic blockade of ACVR2B ligands prevents chemotherapy-induced muscle wasting by restoring muscle protein synthesis without affecting oxidative capacity or atrogenes.
  publication-title: Sci. Rep.
  doi: 10.1038/srep32695
– volume: 51
  start-page: 1573
  year: 2019
  ident: B101
  article-title: Persistent impairment in cardiopulmonary fitness after breast cancer chemotherapy.
  publication-title: Med. Sci. Sports Exerc.
  doi: 10.1249/MSS.0000000000001970
– volume: 6
  start-page: 25
  year: 2013
  ident: B44
  article-title: Cellular and molecular mechanisms of muscle atrophy.
  publication-title: Dis. Model. Mech.
  doi: 10.1242/dmm.010389
– volume: 149
  start-page: 79
  year: 2018
  ident: B229
  article-title: Effects of the beta2 agonist formoterol on atrophy signaling, autophagy, and muscle phenotype in respiratory and limb muscles of rats with cancer-induced cachexia.
  publication-title: Biochimie
  doi: 10.1016/j.biochi.2018.04.009
– volume: 97
  start-page: 552
  year: 2013
  ident: B29
  article-title: Associations between body composition and gait-speed decline: results from the Health, Aging, and Body Composition study.
  publication-title: Am. J. Clin. Nutr.
  doi: 10.3945/ajcn.112.047860
– volume: 9
  year: 2019
  ident: B160
  article-title: IMB0901 inhibits muscle atrophy induced by cancer cachexia through MSTN signaling pathway.
  publication-title: Skelet. Muscle
  doi: 10.1186/s13395-019-0193-2
– volume: 36
  start-page: 403
  year: 2003
  ident: B87
  article-title: Muscles in microgravity: from fibres to human motion.
  publication-title: J. Biomech.
  doi: 10.1016/s0021-9290(02)00418-9
– volume: 2
  year: 2012
  ident: B284
  article-title: IL-6 regulation on skeletal muscle mitochondrial remodeling during cancer cachexia in the ApcMin/+ mouse.
  publication-title: Skelet. Muscle
  doi: 10.1186/2044-5040-2-14
– volume: 205
  start-page: 398
  year: 2016
  ident: B171
  article-title: Preoperative cancer cachexia and short-term outcomes following surgery.
  publication-title: J. Surg. Res.
  doi: 10.1016/j.jss.2016.06.076
– volume: 237
  start-page: 384
  year: 2003
  ident: B47
  article-title: Increased muscle proteasome activity correlates with disease severity in gastric cancer patients.
  publication-title: Ann. Surg.
  doi: 10.1097/01.SLA.0000055225.96357.71
– volume: 12
  year: 2012
  ident: B249
  article-title: Real-imaging cDNA-AFLP transcript profiling of pancreatic cancer patients: Egr-1 as a potential key regulator of muscle cachexia.
  publication-title: BMC Cancer
  doi: 10.1186/1471-2407-12-265
– volume: 66
  start-page: 11
  year: 2019
  ident: B14
  article-title: Mediators of cachexia in cancer patients.
  publication-title: Nutrition
  doi: 10.1016/j.nut.2019.03.012
– volume: 9
  year: 2014
  ident: B133
  article-title: Clinical classification of cancer cachexia: phenotypic correlates in human skeletal muscle.
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0083618
– volume: 54
  start-page: 407
  year: 2019
  ident: B234
  article-title: From chemotherapy to biological therapy: a review of novel concepts to reduce the side effects of systemic cancer treatment (Review).
  publication-title: Int. J. Oncol.
  doi: 10.3892/ijo.2018.4661
– volume: 3
  year: 2014
  ident: B199
  article-title: Cardiorespiratory fitness in breast cancer patients: a call for normative values.
  publication-title: J. Am. Heart Assoc.
  doi: 10.1161/JAHA.113.000432
– volume: 181
  start-page: 411
  ident: B6
  article-title: Association of body composition with function in women with early breast cancer.
  publication-title: Breast Cancer Res. Treat.
  doi: 10.1007/s10549-020-05624-3
– volume: 40
  start-page: 473
  year: 2005
  ident: B89
  article-title: Apoptosis in muscle atrophy: relevance to sarcopenia.
  publication-title: Exp. Gerontol.
  doi: 10.1016/j.exger.2005.04.003
– volume: 71
  start-page: 4361
  year: 2014
  ident: B223
  article-title: Myostatin and the skeletal muscle atrophy and hypertrophy signaling pathways.
  publication-title: Cell. Mol. Life Sci. CMLS
  doi: 10.1007/s00018-014-1689-x
– volume: 9
  start-page: 315
  year: 2018
  ident: B79
  article-title: Loss of skeletal muscle during systemic chemotherapy is prognostic of poor survival in patients with foregut cancer.
  publication-title: J. Cachexia Sarcopenia Muscle
  doi: 10.1002/jcsm.12267
– volume: 98
  start-page: 738
  year: 2013
  ident: B196
  article-title: Nuclear transcription factor κ B activation and protein turnover adaptations in skeletal muscle of patients with progressive stages of lung cancer cachexia.
  publication-title: Am. J. Clin. Nutr.
  doi: 10.3945/ajcn.113.058388
– volume: 17
  start-page: 1
  year: 2021
  ident: B148
  article-title: Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition).
  publication-title: Autophagy
  doi: 10.1080/15548627.2020.1797280
– volume: 23
  start-page: 117
  year: 2006
  ident: B156
  article-title: Activin A circulating levels in patients with bone metastasis from breast or prostate cancer.
  publication-title: Clin. Exp. Metastasis
  doi: 10.1007/s10585-006-9010-5
– volume: 65
  start-page: 190
  year: 2015
  ident: B35
  article-title: Screening, evaluation, and management of cancer-related fatigue: ready for implementation to practice?
  publication-title: CA Cancer J. Clin.
  doi: 10.3322/caac.21268
– volume: 45
  start-page: 2200
  year: 2013
  ident: B40
  article-title: Disuse-induced muscle wasting.
  publication-title: Int. J. Biochem. Cell Biol.
  doi: 10.1016/j.biocel.2013.06.011
– volume: 98
  start-page: 14440
  year: 2001
  ident: B111
  article-title: Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy.
  publication-title: Proc. Natl. Acad. Sci. U.S.A.
  doi: 10.1073/pnas.251541198
– volume: 33
  start-page: 1918
  year: 2015
  ident: B275
  article-title: Effect of low-intensity physical activity and moderate- to high-intensity physical exercise during adjuvant chemotherapy on physical fitness, fatigue, and chemotherapy completion rates: results of the PACES randomized clinical trial.
  publication-title: J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol.
  doi: 10.1200/JCO.2014.59.1081
– volume: 33
  start-page: 5482
  year: 2019
  ident: B22
  article-title: Moderate exercise in mice improves cancer plus chemotherapy-induced muscle wasting and mitochondrial alterations.
  publication-title: FASEB J.
  doi: 10.1096/fj.201801862R
– volume: 99
  start-page: 427
  year: 2019
  ident: B151
  article-title: Sarcopenia: aging-related loss of muscle mass and function.
  publication-title: Physiol. Rev.
  doi: 10.1152/physrev.00061.2017
– volume: 42
  start-page: 479
  year: 2019
  ident: B64
  article-title: Matrine improves skeletal muscle atrophy by inhibiting E3 ubiquitin ligases and activating the Akt/mTOR/FoxO3α signaling pathway in C2C12 myotubes and mice.
  publication-title: Oncol. Rep.
  doi: 10.3892/or.2019.7205
– volume: 5
  ident: B270
  article-title: Roles of nonmyogenic mesenchymal progenitors in pathogenesis and regeneration of skeletal muscle.
  publication-title: Front. Physiol.
  doi: 10.3389/fphys.2014.00068
– volume: 311
  start-page: E594
  year: 2016
  ident: B16
  article-title: Control of skeletal muscle atrophy in response to disuse: clinical/preclinical contentions and fallacies of evidence.
  publication-title: Am. J. Physiol. Endocrinol. Metab.
  doi: 10.1152/ajpendo.00257.2016
– volume: 280
  start-page: 4294
  year: 2013
  ident: B233
  article-title: Mechanisms regulating skeletal muscle growth and atrophy.
  publication-title: FEBS J.
  doi: 10.1111/febs.12253
– volume: 145
  ident: B7
  article-title: Myosteatosis and prognosis in cancer: systematic review and meta-analysis.
  publication-title: Crit. Rev. Oncol. Hematol.
  doi: 10.1016/j.critrevonc.2019.102839
– volume: 14
  start-page: 754
  year: 2014
  ident: B13
  article-title: Cancer cachexia: understanding the molecular basis.
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc3829
– volume: 17
  start-page: 241
  year: 2014
  ident: B200
  article-title: Coming back: autophagy in cachexia.
  publication-title: Curr. Opin. Clin. Nutr. Metab. Care
  doi: 10.1097/MCO.0000000000000048
– volume: 16
  start-page: 977
  year: 1961
  ident: B15
  article-title: Maximal oxygen uptake and heart rate in various types of muscular activity.
  publication-title: J. Appl. Physiol.
  doi: 10.1152/jappl.1961.16.6.977
– volume: 210
  start-page: 489
  year: 2014
  ident: B17
  article-title: Measurement of skeletal muscle radiation attenuation and basis of its biological variation.
  publication-title: Acta Physiol. Oxf. Engl.
  doi: 10.1111/apha.12224
– volume: 11
  start-page: 195
  year: 2020
  ident: B206
  article-title: Autocrine activin A signalling in ovarian cancer cells regulates secretion of interleukin 6, autophagy, and cachexia.
  publication-title: J. Cachexia Sarcopenia Muscle
  doi: 10.1002/jcsm.12489
– volume: 43
  start-page: 717
  year: 2011
  ident: B260
  article-title: Suction-modified Bergström muscle biopsy technique: experience with 13,500 procedures.
  publication-title: Muscle Nerve
  doi: 10.1002/mus.21945
– volume: 6
  year: 2011
  ident: B283
  article-title: The regulation of skeletal muscle protein turnover during the progression of cancer cachexia in the Apc(Min/+) mouse.
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0024650
– volume: 112
  start-page: 79
  year: 2011
  ident: B185
  article-title: Preferential reductions in intermuscular and visceral adipose tissue with exercise-induced weight loss compared with calorie restriction.
  publication-title: J. Appl. Physiol.
  doi: 10.1152/japplphysiol.00355.2011
– volume: 22
  year: 2021
  ident: B105
  article-title: Confounding roles of ER stress and the unfolded protein response in skeletal muscle atrophy.
  publication-title: Int. J. Mol. Sci.
  doi: 10.3390/ijms22052567
– volume: 91
  start-page: 408
  year: 2004
  ident: B250
  article-title: Effect of eicosapentaenoic acid, protein and amino acids on protein synthesis and degradation in skeletal muscle of cachectic mice.
  publication-title: Br. J. Cancer
  doi: 10.1038/sj.bjc.6601981
– volume: 12
  start-page: 489
  year: 2011
  ident: B94
  article-title: Definition and classification of cancer cachexia: an international consensus.
  publication-title: Lancet Oncol.
  doi: 10.1016/S1470-2045(10)70218-7
– volume: 240
  start-page: 410
  year: 2016
  ident: B129
  article-title: PDGFRα signalling promotes fibrogenic responses in collagen-producing cells in Duchenne muscular dystrophy.
  publication-title: J. Pathol.
  doi: 10.1002/path.4801
– volume: 7
  start-page: 3
  year: 2019
  ident: B98
  article-title: Drug combinations in breast cancer therapy.
  publication-title: Pharm. Nanotechnol.
  doi: 10.2174/2211738507666190122111224
– volume: 9
  start-page: 493
  year: 1961
  ident: B174
  article-title: Satellite cell of skeletal muscle fibers.
  publication-title: J. Biophys. Biochem. Cytol.
  doi: 10.1083/jcb.9.2.493
– volume: 87
  start-page: 92
  year: 2017
  ident: B170
  article-title: Altered mitochondrial quality control signaling in muscle of old gastric cancer patients with cachexia.
  publication-title: Exp. Gerontol.
  doi: 10.1016/j.exger.2016.10.003
– volume: 11
  year: 2019
  ident: B81
  article-title: Human cachexia induces changes in mitochondria, autophagy and apoptosis in the skeletal muscle.
  publication-title: Cancers
  doi: 10.3390/cancers11091264
– volume: 177
  start-page: 237
  year: 2019
  ident: B132
  article-title: HER2+ breast cancer treatment and cardiotoxicity: monitoring and management.
  publication-title: Breast Cancer Res. Treat.
  doi: 10.1007/s10549-019-05303-y
– volume: 434
  start-page: 246
  year: 1997
  ident: B137
  article-title: Decline in isokinetic force with age: muscle cross-sectional area and specific force.
  publication-title: Pflugers Arch.
  doi: 10.1007/s004240050392
– volume: 593
  start-page: 2017
  year: 2015
  ident: B180
  article-title: Increased mitochondrial emission of reactive oxygen species and calpain activation are required for doxorubicin-induced cardiac and skeletal muscle myopathy.
  publication-title: J. Physiol.
  doi: 10.1113/jphysiol.2014.286518
– volume: 5
  year: 2015
  ident: B115
  article-title: Anthracycline-containing chemotherapy causes long-term impairment of mitochondrial respiration and increased reactive oxygen species release in skeletal muscle.
  publication-title: Sci. Rep.
  doi: 10.1038/srep08717
– volume: 99
  start-page: 2379
  year: 2005
  ident: B177
  article-title: Myofiber degeneration/regeneration is induced in the cachectic ApcMin/+ mouse.
  publication-title: J. Appl. Physiol. Bethesda Md 1985
  doi: 10.1152/japplphysiol.00778.2005
– volume: 14
  start-page: 257
  year: 2005
  ident: B84
  article-title: Systemic inflammation correlates with increased expression of skeletal muscle ubiquitin but not uncoupling proteins in cancer cachexia.
  publication-title: Oncol. Rep.
– volume: 67
  start-page: 680
  year: 1993
  ident: B252
  article-title: Increased protein degradation and decreased protein synthesis in skeletal muscle during cancer cachexia.
  publication-title: Br. J. Cancer
  doi: 10.1038/bjc.1993.126
– volume: 4
  start-page: 798
  year: 2018
  ident: B56
  article-title: Association of muscle and adiposity measured by computed tomography with survival in patients with nonmetastatic breast cancer.
  publication-title: JAMA Oncol.
  doi: 10.1001/jamaoncol.2018.0137
– volume: 92
  start-page: 2783
  year: 1993
  ident: B73
  article-title: Tumor necrosis factor-alpha mediates changes in tissue protein turnover in a rat cancer cachexia model.
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI116897
– volume: 11
  start-page: 1413
  year: 2020
  ident: B88
  article-title: Cancer cachexia and skeletal muscle atrophy in clinical studies: what do we really know?
  publication-title: J. Cachexia Sarcopenia Muscle
  doi: 10.1002/jcsm.12633
– volume: 311
  start-page: C101
  year: 2016
  ident: B258
  article-title: Valproic acid attenuates skeletal muscle wasting by inhibiting C/EBPβ-regulated atrogin1 expression in cancer cachexia.
  publication-title: Am. J. Physiol. Cell Physiol.
  doi: 10.1152/ajpcell.00344.2015
– volume: 11
  start-page: 619
  year: 2020
  ident: B246
  article-title: Cancer cachexia and its pathophysiology: links with sarcopenia, anorexia and asthenia.
  publication-title: J. Cachexia Sarcopenia Muscle
  doi: 10.1002/jcsm.12528
– volume: 7
  start-page: 615
  year: 2016
  ident: B83
  article-title: Doxorubicin caused severe hyperglycaemia and insulin resistance, mediated by inhibition in AMPk signalling in skeletal muscle.
  publication-title: J. Cachexia Sarcopenia Muscle
  doi: 10.1002/jcsm.12104
– volume: 12
  year: 2021
  ident: B262
  article-title: Evolving roles of muscle-resident fibro-adipogenic progenitors in health, regeneration, neuromuscular disorders, and aging.
  publication-title: Front. Physiol.
  doi: 10.3389/fphys.2021.673404
– volume: 98
  start-page: 208
  year: 2016
  ident: B209
  article-title: Redox control of skeletal muscle atrophy.
  publication-title: Free Radic. Biol. Med.
  doi: 10.1016/j.freeradbiomed.2016.02.021
– volume: 2
  start-page: 1
  year: 2017
  ident: B161
  article-title: Lean body mass, muscle fibre size and muscle function in cancer patients during chemotherapy and 10 weeks exercise.
  publication-title: JCSM Clin. Rep.
  doi: 10.17987/jcsm-cr.v2i1.26
– volume: 111
  start-page: 570
  year: 2020
  ident: B296
  article-title: The autophagic-lysosomal and ubiquitin proteasome systems are simultaneously activated in the skeletal muscle of gastric cancer patients with cachexia.
  publication-title: Am. J. Clin. Nutr.
  doi: 10.1093/ajcn/nqz347
– volume: 17
  year: 2020
  ident: B168
  article-title: Effects of chemotherapy treatment on muscle strength, quality of life, fatigue, and anxiety in women with breast cancer.
  publication-title: Int. J. Environ. Res. Public. Health
  doi: 10.3390/ijerph17197289
– volume: 19
  start-page: 391
  year: 2011
  ident: B248
  article-title: Interaction of gonadal status with systemic inflammation and opioid use in determining nutritional status and prognosis in advanced pancreatic cancer.
  publication-title: Support. Care Cancer Off. J. Multinatl. Assoc. Support. Care Cancer
  doi: 10.1007/s00520-010-0832-y
– volume: 177
  start-page: 569
  year: 2019
  ident: B8
  article-title: Muscle composition and outcomes in patients with breast cancer: meta-analysis and systematic review.
  publication-title: Breast Cancer Res. Treat.
  doi: 10.1007/s10549-019-05352-3
– volume: 289
  start-page: 584
  year: 1984
  ident: B92
  article-title: Protein synthesis in muscle measured in vivo in cachectic patients with cancer.
  publication-title: Br. Med. J. Clin. Res. Ed
  doi: 10.1136/bmj.289.6445.584
– volume: 5
  year: 2010
  ident: B203
  article-title: Muscle wasting and impaired myogenesis in tumor bearing mice are prevented by ERK inhibition.
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0013604
– volume: 569
  start-page: 201
  year: 2004
  ident: B97
  article-title: Interleukin-15 is able to suppress the increased DNA fragmentation associated with muscle wasting in tumour-bearing rats.
  publication-title: FEBS Lett.
  doi: 10.1016/j.febslet.2004.05.066
– volume: 23
  start-page: 80
  year: 2020
  ident: B124
  article-title: Prognostic value of skeletal muscle depletion measured on computed tomography for overall survival in patients with non-metastatic breast cancer.
  publication-title: J. Breast Cancer
  doi: 10.4048/jbc.2020.23.e8
– volume: 17
  year: 2017
  ident: B238
  article-title: The clinical picture of cachexia: a mosaic of different parameters (experience of 503 patients).
  publication-title: BMC Cancer
  doi: 10.1186/s12885-017-3116-9
– volume: 27
  start-page: 15
  year: 2011
  ident: B71
  article-title: Nuclear magnetic resonance in conjunction with functional genomics suggests mitochondrial dysfunction in a murine model of cancer cachexia.
  publication-title: Int. J. Mol. Med.
  doi: 10.3892/ijmm.2010.557
– volume: 8
  start-page: 279
  year: 2001
  ident: B131
  article-title: Expression of apoptosis regulatory proteins in the skeletal muscle of tumor-bearing rabbits compared with diet-restricted rabbits.
  publication-title: Int. J. Mol. Med.
  doi: 10.3892/ijmm.8.3.279
– volume: 11
  year: 2019
  ident: B154
  article-title: Z-ajoene from crushed garlic alleviates cancer-induced skeletal muscle atrophy.
  publication-title: Nutrients
  doi: 10.3390/nu11112724
– volume: 229
  start-page: 1660
  year: 2014
  ident: B60
  article-title: Pharmacological strategies in lung cancer-induced cachexia: effects on muscle proteolysis, autophagy, structure, and weakness.
  publication-title: J. Cell. Physiol.
  doi: 10.1002/jcp.24611
– volume: 28
  year: 2018
  ident: B80
  article-title: Chemotherapy-induced muscle wasting: association with NF-κB and cancer cachexia.
  publication-title: Eur. J. Transl. Myol.
  doi: 10.4081/ejtm.2018.7590
– volume: 123
  start-page: 4821
  year: 2013
  ident: B121
  article-title: NF-κB-mediated Pax7 dysregulation in the muscle microenvironment promotes cancer cachexia.
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI68523
– volume: 50
  start-page: 897
  year: 2002
  ident: B278
  article-title: Leg muscle mass and composition in relation to lower extremity performance in men and women aged 70 to 79: the health, aging and body composition study.
  publication-title: J. Am. Geriatr. Soc.
  doi: 10.1046/j.1532-5415.2002.50217.x
– volume: 52
  start-page: 1239
  year: 2020
  ident: B58
  article-title: Heavy resistance training in breast cancer patients undergoing adjuvant therapy.
  publication-title: Med. Sci. Sports Exerc.
  doi: 10.1249/MSS.0000000000002260
– volume: 18
  start-page: 39
  year: 2004
  ident: B152
  article-title: Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression.
  publication-title: FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol.
  doi: 10.1096/fj.03-0610com
– volume: 11
  start-page: 1779
  year: 2020
  ident: B127
  article-title: ACVR2B antagonism as a countermeasure to multi-organ perturbations in metastatic colorectal cancer cachexia.
  publication-title: J. Cachexia Sarcopenia Muscle
  doi: 10.1002/jcsm.12642
– volume: 43
  start-page: 886
  year: 2013
  ident: B268
  article-title: Skeletal muscle mitochondrial uncoupling in a murine cancer cachexia model.
  publication-title: Int. J. Oncol.
  doi: 10.3892/ijo.2013.1998
– volume: 124
  start-page: 3654
  year: 2011
  ident: B271
  article-title: Fibrosis and adipogenesis originate from a common mesenchymal progenitor in skeletal muscle.
  publication-title: J. Cell Sci.
  doi: 10.1242/jcs.086629
– volume: 35
  start-page: 5623
  year: 2015
  ident: B235
  article-title: Comparing endurance and resistance training with standard care during chemotherapy for patients with primary breast cancer.
  publication-title: Anticancer Res.
– volume: 23
  start-page: 1153
  year: 2018
  ident: B242
  article-title: Adjuvant anthracyclines in breast cancer: what is their role?
  publication-title: The Oncologist
  doi: 10.1634/theoncologist.2017-0672
– volume: 13
  year: 2018
  ident: B130
  article-title: Muscle regeneration is disrupted by cancer cachexia without loss of muscle stem cell potential.
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0205467
– volume: 268
  start-page: E996
  year: 1995
  ident: B24
  article-title: Activation of the ATP-ubiquitin-proteasome pathway in skeletal muscle of cachectic rats bearing a hepatoma.
  publication-title: Am. J. Physiol.
  doi: 10.1152/ajpendo.1995.268.5.E996
– volume: 30
  start-page: 1239
  year: 2007
  ident: B183
  article-title: The AP-1/NF-kappaB double inhibitor SP100030 can revert muscle wasting during experimental cancer cachexia.
  publication-title: Int. J. Oncol.
– volume: 12
  year: 2017
  ident: B75
  article-title: Cyclophosphamide leads to persistent deficits in physical performance and in vivo mitochondria function in a mouse model of chemotherapy late effects.
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0181086
– volume: 121
  start-page: 369
  year: 2021
  ident: B256
  article-title: Echo intensity as an indicator of skeletal muscle quality: applications, methodology, and future directions.
  publication-title: Eur. J. Appl. Physiol.
  doi: 10.1007/s00421-020-04556-6
– volume: 26
  start-page: 861
  year: 2018
  ident: B86
  article-title: Impact of body composition on outcome in patients with early breast cancer.
  publication-title: Support. Care Cancer
  doi: 10.1007/s00520-017-3902-6
– volume: 84
  start-page: 1135
  year: 2001
  ident: B32
  article-title: Cleavage of caspases-1, -3, -6, -8 and -9 substrates by proteases in skeletal muscles from mice undergoing cancer cachexia.
  publication-title: Br. J. Cancer
  doi: 10.1054/bjoc.2001.1700
– volume: 14
  year: 2016
  ident: B228
  article-title: Phenotypic and metabolic features of mouse diaphragm and gastrocnemius muscles in chronic lung carcinogenesis: influence of underlying emphysema.
  publication-title: J. Transl. Med.
  doi: 10.1186/s12967-016-1003-9
– volume: 9
  start-page: 514
  year: 2018
  ident: B192
  article-title: Treating cachexia using soluble ACVR2B improves survival, alters mTOR localization, and attenuates liver and spleen responses.
  publication-title: J. Cachexia Sarcopenia Muscle
  doi: 10.1002/jcsm.12310
– volume: 8
  start-page: 39640
  year: 2017
  ident: B118
  article-title: Pantoprazole blocks the JAK2/STAT3 pathway to alleviate skeletal muscle wasting in cancer cachexia by inhibiting inflammatory response.
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.17387
– volume: 25
  start-page: 365
  year: 2017
  ident: B224
  article-title: Weight loss versus muscle loss: re-evaluating inclusion criteria for future cancer cachexia interventional trials.
  publication-title: Support. Care Cancer
  doi: 10.1007/s00520-016-3402-0
– volume: 92
  start-page: 631
  year: 2001
  ident: B292
  article-title: Expression of apoptosis regulatory proteins in the skeletal muscle of tumor-bearing rabbits.
  publication-title: Jpn. J. Cancer Res. Gann
  doi: 10.1111/j.1349-7006.2001.tb01141.x
– volume: 10
  year: 2021
  ident: B128
  article-title: Mitochondrial dysfunction is a common denominator linking skeletal muscle wasting due to disease, aging, and prolonged inactivity.
  publication-title: Antioxid. Basel Switz.
  doi: 10.3390/antiox10040588
– volume: 157
  start-page: 603
  year: 2020
  ident: B3
  article-title: Six-Minute walk test: clinical role, technique, coding, and reimbursement.
  publication-title: Chest
  doi: 10.1016/j.chest.2019.10.014
– volume: 51
  start-page: 6089
  year: 1991
  ident: B30
  article-title: Anticachectic and antitumor effect of eicosapentaenoic acid and its effect on protein turnover.
  publication-title: Cancer Res.
– volume: 229
  year: 2019
  ident: B123
  article-title: Doxorubicin-induced skeletal muscle atrophy: elucidating the underlying molecular pathways.
  publication-title: Acta Physiol. Oxf. Engl.
  doi: 10.1111/apha.13400
– volume: 90
  start-page: 2157
  year: 2001
  ident: B112
  article-title: Attenuation of skeletal muscle and strength in the elderly: the Health ABC Study.
  publication-title: J. Appl. Physiol. Bethesda Md 1985
  doi: 10.1152/jappl.2001.90.6.2157
– volume: 37
  start-page: 2196
  year: 2005
  ident: B145
  article-title: Increased expression of proteasome subunits in skeletal muscle of cancer patients with weight loss.
  publication-title: Int. J. Biochem. Cell Biol.
  doi: 10.1016/j.biocel.2004.10.017
– volume: 14
  start-page: 1085
  year: 2015
  ident: B62
  article-title: Apoptosis and necrosis mediate skeletal muscle fiber loss in age-induced mitochondrial enzymatic abnormalities.
  publication-title: Aging Cell
  doi: 10.1111/acel.12399
– volume: 13
  start-page: 6379
  year: 2007
  ident: B100
  article-title: Daily physical-rest activities in relation to nutritional state, metabolism, and quality of life in cancer patients with progressive cachexia.
  publication-title: Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res.
  doi: 10.1158/1078-0432.CCR-07-1147
– volume: 7
  year: 2019
  ident: B78
  article-title: Chronic doxorubicin administration impacts satellite cell and capillary abundance in a muscle-specific manner.
  publication-title: Physiol. Rep.
  doi: 10.14814/phy2.14052
– volume: 145
  start-page: 1449
  year: 2019
  ident: B181
  article-title: Molecular and cellular adaptations to exercise training in skeletal muscle from cancer patients treated with chemotherapy.
  publication-title: J. Cancer Res. Clin. Oncol.
  doi: 10.1007/s00432-019-02911-5
– volume: 44
  start-page: 386
  year: 1984
  ident: B33
  article-title: Flux of amino acids across the leg in weight-losing cancer patients.
  publication-title: Cancer Res.
– volume: 3
  start-page: 37
  ident: B54
  article-title: Myostatin blockage using actRIIB antagonism in mice bearing the Lewis lung carcinoma results in the improvement of muscle wasting and physical performance.
  publication-title: J. Cachexia Sarcopenia Muscle
  doi: 10.1007/s13539-011-0049-z
– volume: 290
  start-page: 11177
  year: 2015
  ident: B245
  article-title: Inhibition of Stat3 activation suppresses caspase-3 and the ubiquitin-proteasome system, leading to preservation of muscle mass in cancer cachexia.
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M115.641514
– volume: 318
  start-page: R227
  year: 2020
  ident: B182
  article-title: Doxorubicin-induced oxidative stress differentially regulates proteolytic signaling in cardiac and skeletal muscle.
  publication-title: Am. J. Physiol. Regul. Integr. Comp. Physiol.
  doi: 10.1152/ajpregu.00299.2019
– volume: 111
  start-page: 1190
  year: 2011
  ident: B253
  article-title: Exercise protects against doxorubicin-induced markers of autophagy signaling in skeletal muscle.
  publication-title: J. Appl. Physiol. Bethesda Md 1985
  doi: 10.1152/japplphysiol.00429.2011
– volume: 281
  start-page: R133
  year: 2001
  ident: B230
  article-title: Higher skeletal muscle protein synthesis and lower breakdown after chemotherapy in cachectic mice.
  publication-title: Am. J. Physiol. Regul. Integr. Comp. Physiol.
  doi: 10.1152/ajpregu.2001.281.1.R133
– year: 2020
  ident: B289
  article-title: Breast cancer-associated skeletal muscle mitochondrial dysfunction and lipid accumulation is reversed by PPARG.
  publication-title: BioRxiv
  doi: 10.1101/2020.04.05.026617
– volume: 302
  start-page: C195
  year: 2012
  ident: B110
  article-title: Doxorubicin acts via mitochondrial ROS to stimulate catabolism in C2C12 myotubes.
  publication-title: Am. J. Physiol. Cell Physiol.
  doi: 10.1152/ajpcell.00217.2011
– volume: 100
  start-page: 2030
  year: 2015
  ident: B162
  article-title: Role of Activin A and myostatin in human cancer cachexia.
  publication-title: J. Clin. Endocrinol. Metab.
  doi: 10.1210/jc.2014-4318
– volume: 9
  start-page: 19584
  year: 2018
  ident: B65
  article-title: Anti-cachectic effect of Antrodia cinnamomea extract in lung tumor-bearing mice under chemotherapy.
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.24680
– volume: 4
  year: 2013
  ident: B21
  article-title: Alterations in muscle mass and contractile phenotype in response to unloading models: role of transcriptional/pretranslational mechanisms.
  publication-title: Front. Physiol.
  doi: 10.3389/fphys.2013.00284
– volume: 23
  start-page: 160
  year: 2008
  ident: B231
  article-title: Signaling in muscle atrophy and hypertrophy.
  publication-title: Physiol. Bethesda Md
  doi: 10.1152/physiol.00041.2007
– volume: 74
  start-page: 7344
  year: 2014
  ident: B107
  article-title: Myostatin gene inactivation prevents skeletal muscle wasting in cancer.
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-14-0057
– volume: 84
  start-page: 275
  year: 1988
  ident: B158
  article-title: What is the cause of the ageing atrophy? Total number, size and proportion of different fiber types studied in whole vastus lateralis muscle from 15- to 83-year-old men.
  publication-title: J. Neurol. Sci.
  doi: 10.1016/0022-510x(88)90132-3
– volume: 9
  start-page: 701
  year: 2018
  ident: B41
  article-title: Dysregulation of metabolic-associated pathways in muscle of breast cancer patients: preclinical evaluation of interleukin-15 targeting fatigue.
  publication-title: J. Cachexia Sarcopenia Muscle
  doi: 10.1002/jcsm.12294
– volume: 2014
  year: 2014
  ident: B2
  article-title: Intermuscular fat: a review of the consequences and causes.
  publication-title: Int. J. Endocrinol.
  doi: 10.1155/2014/309570
– volume: 11
  start-page: 226
  year: 2020
  ident: B149
  article-title: Derangements of amino acids in cachectic skeletal muscle are caused by mitochondrial dysfunction.
  publication-title: J. Cachexia Sarcopenia Muscle
  doi: 10.1002/jcsm.12498
– volume: 18
  start-page: e1
  year: 2017
  ident: B186
  article-title: Consequences of late-stage non-small-cell lung cancer cachexia on muscle metabolic processes.
  publication-title: Clin. Lung Cancer
  doi: 10.1016/j.cllc.2016.06.003
– volume: 496
  start-page: 746
  year: 2018
  ident: B227
  article-title: 1α,25-dihydroxyvitamin D3 mitigates cancer cell mediated mitochondrial dysfunction in human skeletal muscle cells.
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2018.01.092
– volume: 24
  start-page: 508
  year: 2016
  ident: B103
  article-title: The six-minute walk test as a measure of health in breast cancer patients.
  publication-title: J. Aging Phys. Act.
  doi: 10.1123/japa.2015-0056
– volume: 33
  start-page: 90
  year: 2015
  ident: B169
  article-title: Diagnostic criteria for the classification of cancer-associated weight loss.
  publication-title: J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol.
  doi: 10.1200/JCO.2014.56.1894
– volume: 85
  start-page: 377
  year: 2007
  ident: B166
  article-title: Reduced physical activity increases intermuscular adipose tissue in healthy young adults.
  publication-title: Am. J. Clin. Nutr.
  doi: 10.1093/ajcn/85.2.377
– volume: 9
  year: 2019
  ident: B4
  article-title: Role of reactive oxygen species in cancer progression: molecular mechanisms and recent advancements.
  publication-title: Biomolecules
  doi: 10.3390/biom9110735
– volume: 82
  start-page: 42
  year: 1998
  ident: B90
  article-title: Effects of cachexia due to cancer on whole body and skeletal muscle protein turnover.
  publication-title: Cancer
  doi: 10.1002/(SICI)1097-0142(19980101)82:1<42::AID-CNCR5>3.0.CO;2-M
– volume: 36
  start-page: 326
  year: 2015
  ident: B222
  article-title: Anthracyclines/trastuzumab: new aspects of cardiotoxicity and molecular mechanisms.
  publication-title: Trends Pharmacol. Sci.
  doi: 10.1016/j.tips.2015.03.005
– volume: 76
  start-page: 5372
  year: 2016
  ident: B63
  article-title: Differential effects of IL6 and activin a in the development of cancer-associated cachexia.
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-15-3152
– volume: 38
  year: 2020
  ident: B285
  article-title: Pectoralis muscle wasting during chemotherapy.
  publication-title: J. Clin. Oncol.
  doi: 10.1200/JCO.2020.38.15_suppl.e24069
– volume: 7
  start-page: 51608
  year: 2016
  ident: B66
  article-title: Combined administration of fucoidan ameliorates tumor and chemotherapy-induced skeletal muscle atrophy in bladder cancer-bearing mice.
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.9958
– volume: 5
  year: 2019
  ident: B122
  article-title: Sclerostin inhibition alleviates breast cancer-induced bone metastases and muscle weakness.
  publication-title: JCI Insight
  doi: 10.1172/jci.insight.125543
– volume: 6
  start-page: 164
  year: 2015
  ident: B194
  article-title: Preserved muscle oxidative metabolic phenotype in newly diagnosed non-small cell lung cancer cachexia.
  publication-title: J. Cachexia Sarcopenia Muscle
  doi: 10.1002/jcsm.12007
– volume: 14
  start-page: 14
  year: 2008
  ident: B39
  article-title: Cardiac toxicity in breast cancer survivors: review of potential cardiac problems.
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.CCR-07-1033
– volume: 19
  start-page: 1350
  year: 2012
  ident: B18
  article-title: Changes in myostatin signaling in non-weight-losing cancer patients.
  publication-title: Ann. Surg. Oncol.
  doi: 10.1245/s10434-011-1720-5
– volume: 29
  start-page: ii10
  year: 2018
  ident: B11
  article-title: Muscle protein anabolism in advanced cancer patients: response to protein and amino acids support, and to physical activity.
  publication-title: Ann. Oncol. Off. J. Eur. Soc. Med. Oncol.
  doi: 10.1093/annonc/mdx809
– volume: 311
  start-page: E293
  year: 2016
  ident: B109
  article-title: Targeted overexpression of mitochondrial catalase protects against cancer chemotherapy-induced skeletal muscle dysfunction.
  publication-title: Am. J. Physiol. Endocrinol. Metab.
  doi: 10.1152/ajpendo.00540.2015
– volume: 44
  start-page: 814
  year: 2019
  ident: B146
  article-title: MRI quantitation of abdominal skeletal muscle correlates with CT-based analysis: implications for sarcopenia measurement.
  publication-title: Appl. Physiol. Nutr. Metab. Physiol. Appl. Nutr. Metab.
  doi: 10.1139/apnm-2018-0473
– volume: 9
  start-page: 685
  year: 2018
  ident: B208
  article-title: Growth of ovarian cancer xenografts causes loss of muscle and bone mass: a new model for the study of cancer cachexia.
  publication-title: J. Cachexia Sarcopenia Muscle
  doi: 10.1002/jcsm.12311
– volume: 21
  year: 2020
  ident: B274
  article-title: Signaling pathways that control muscle mass.
  publication-title: Int. J. Mol. Sci.
  doi: 10.3390/ijms21134759
– volume: 40
  start-page: 59
  year: 2019
  ident: B189
  article-title: Colon 26 adenocarcinoma (C26)-induced cancer cachexia impairs skeletal muscle mitochondrial function and content.
  publication-title: J. Muscle Res. Cell Motil.
  doi: 10.1007/s10974-019-09510-4
– volume: 6
  start-page: 264
  year: 2019
  ident: B59
  article-title: Body composition, adherence to anthracycline and taxane-based chemotherapy, and survival after nonmetastatic breast cancer.
  publication-title: JAMA Oncol.
  doi: 10.1001/jamaoncol.2019.4668
– volume: 138
  start-page: 2021
  year: 2016
  ident: B263
  article-title: Complete reversal of muscle wasting in experimental cancer cachexia: additive effects of activin type II receptor inhibition and β-2 agonist.
  publication-title: Int. J. Cancer
  doi: 10.1002/ijc.29930
– volume: 35
  start-page: 609
  year: 1975
  ident: B36
  article-title: Percutaneous needle biopsy of skeletal muscle in physiological and clinical research.
  publication-title: Scand. J. Clin. Lab. Invest.
  doi: 10.3109/00365517509095787
– volume: 162
  start-page: 1365
  year: 2015
  ident: B135
  article-title: Targeting of Fn14 prevents cancer-induced cachexia and prolongs survival.
  publication-title: Cell
  doi: 10.1016/j.cell.2015.08.031
– volume: 5
  ident: B269
  article-title: Identification and characterization of PDGFRα+ mesenchymal progenitors in human skeletal muscle.
  publication-title: Cell Death Dis.
  doi: 10.1038/cddis.2014.161
– volume: 21
  start-page: 1396
  year: 2016
  ident: B219
  article-title: The prevalence and prognostic value of low muscle mass in cancer patients: a review of the literature.
  publication-title: The Oncologist
  doi: 10.1634/theoncologist.2016-0066
– volume: 904
  start-page: 18
  year: 2000
  ident: B113
  article-title: Composition of skeletal muscle evaluated with computed tomography.
  publication-title: Ann. N. Y. Acad. Sci.
  doi: 10.1111/j.1749-6632.2000.tb06416.x
– volume: 79
  start-page: 874
  year: 2004
  ident: B254
  article-title: Sarcopenia and increased adipose tissue infiltration of muscle in elderly African American women.
  publication-title: Am. J. Clin. Nutr.
  doi: 10.1093/ajcn/79.5.874
– volume: 8
  year: 2017
  ident: B255
  article-title: BGP-15 protects against oxaliplatin-induced skeletal myopathy and mitochondrial reactive oxygen species production in mice.
  publication-title: Front. Pharmacol.
  doi: 10.3389/fphar.2017.00137
– volume: 9
  year: 2019
  ident: B287
  article-title: Taxanes for adjuvant treatment of early breast cancer.
  publication-title: Cochrane Database Syst. Rev.
  doi: 10.1002/14651858.CD004421.pub3
– volume: 7
  year: 2012
  ident: B117
  article-title: Electrical stimulation influences satellite cell proliferation and apoptosis in unloading-induced muscle atrophy in mice.
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0030348
– volume: 14
  start-page: 362
  year: 2010
  ident: B167
  article-title: Skeletal muscle fat infiltration: impact of age, inactivity, and exercise.
  publication-title: J. Nutr. Health Aging
  doi: 10.1007/s12603-010-0081-2
– volume: 81
  start-page: 1339
  year: 2010
  ident: B173
  article-title: Treatment of breast cancer.
  publication-title: Am. Fam. Physician
– volume: 45
  start-page: 1399
  year: 2013
  ident: B197
  article-title: Bladder cancer-induced skeletal muscle wasting: disclosing the role of mitochondria plasticity.
  publication-title: Int. J. Biochem. Cell Biol.
  doi: 10.1016/j.biocel.2013.04.014
– volume: 30
  start-page: 559
  year: 2020
  ident: B282
  article-title: The 6-min walk test in the functional evaluation of patients with lung cancer qualified for lobectomy.
  publication-title: Interact. Cardiovasc. Thorac. Surg.
  doi: 10.1093/icvts/ivz313
– volume: 7
  year: 2020
  ident: B218
  article-title: Plasma lipid profile and systemic inflammation in patients with cancer cachexia.
  publication-title: Front. Nutr.
  doi: 10.3389/fnut.2020.00004
– volume: 23
  start-page: 3537
  year: 2017
  ident: B241
  article-title: Body composition as a predictor of toxicity in patients receiving anthracycline and taxane–based chemotherapy for early-stage breast cancer.
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.CCR-16-2266
– volume: 9
  year: 2018
  ident: B276
  article-title: Antineoplastic drug-induced cardiotoxicity: a redox perspective.
  publication-title: Front. Physiol.
  doi: 10.3389/fphys.2018.00167
– volume: 184
  start-page: 610
  year: 1932
  ident: B281
  article-title: The immediate causes of death in cancer.
  publication-title: Am. J. Med. Sci.
  doi: 10.1097/00000441-193211000-00002
– volume: 8
  start-page: 421
  year: 2005
  ident: B1
  article-title: Dystrophin glycoprotein complex dysfunction: a regulatory link between muscular dystrophy and cancer cachexia.
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2005.10.004
– volume: 190
  start-page: W8
  year: 2008
  ident: B290
  article-title: Three-point technique of fat quantification of muscle tissue as a marker of disease progression in Duchenne muscular dystrophy: preliminary study.
  publication-title: AJR Am. J. Roentgenol.
  doi: 10.2214/AJR.07.2732
– volume: 73
  start-page: 1560
  year: 1996
  ident: B240
  article-title: The relationship between weight loss and interleukin 6 in non-small-cell lung cancer.
  publication-title: Br. J. Cancer
  doi: 10.1038/bjc.1996.294
– volume: 39
  year: 2019
  ident: B43
  article-title: The toll-like receptor/MyD88/XBP1 signaling axis mediates skeletal muscle wasting during cancer cachexia.
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.00184-19
– volume: 73
  start-page: 2047
  year: 2003
  ident: B266
  article-title: Reactive oxygen species mediate doxorubicin induced p53-independent apoptosis.
  publication-title: Life Sci.
  doi: 10.1016/s0024-3205(03)00566-6
– volume: 431
  start-page: 2674
  ident: B202
  article-title: Autophagy exacerbates muscle wasting in cancer cachexia and impairs mitochondrial function.
  publication-title: J. Mol. Biol.
  doi: 10.1016/j.jmb.2019.05.032
– volume: 93
  start-page: 493
  year: 2013
  ident: B215
  article-title: Neoadjuvant chemotherapy in the treatment of breast cancer.
  publication-title: Surg. Clin. North Am.
  doi: 10.1016/j.suc.2013.01.006
– volume: 48
  start-page: 783
  year: 2003
  ident: B93
  article-title: The six-minute walk test.
  publication-title: Respir. Care
– volume: 38
  start-page: 531
  year: 2008
  ident: B74
  article-title: Muscle myostatin signalling is enhanced in experimental cancer cachexia.
  publication-title: Eur. J. Clin. Invest.
  doi: 10.1111/j.1365-2362.2008.01970.x
– volume: 435
  start-page: 488
  year: 2013
  ident: B221
  article-title: Cancer cachexia decreases specific force and accelerates fatigue in limb muscle.
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2013.05.018
– volume: 4
  start-page: 133
  year: 2012
  ident: B243
  article-title: Disruption of MEF2C signaling and loss of sarcomeric and mitochondrial integrity in cancer-induced skeletal muscle wasting.
  publication-title: Aging
  doi: 10.18632/aging.100436
– volume: 299
  start-page: C307
  year: 2010
  ident: B10
  article-title: Oxidative stress, apoptosis, and proteolysis in skeletal muscle repair after unloading.
  publication-title: Am. J. Physiol. Cell Physiol.
  doi: 10.1152/ajpcell.00069.2010
– volume: 18
  start-page: 479
  year: 2020
  ident: B144
  article-title: Role of immunotherapy in triple-negative breast cancer.
  publication-title: J. Natl. Compr. Cancer Netw. JNCCN
  doi: 10.6004/jnccn.2020.7554
– volume: 29
  start-page: 3593
  year: 2020
  ident: B291
  article-title: Physical activity level, exercise behavior, barriers, and preferences of patients with breast cancer-related lymphedema.
  publication-title: Support. Care Cancer Off. J. Multinatl. Assoc. Support. Care Cancer
  doi: 10.1007/s00520-020-05858-3
– volume: 137
  start-page: 2558
  year: 2015
  ident: B172
  article-title: Tumor inoculation site affects the development of cancer cachexia and muscle wasting.
  publication-title: Int. J. Cancer
  doi: 10.1002/ijc.29620
– volume: 7
  year: 2017
  ident: B247
  article-title: Growth hormone secretagogues hexarelin and JMV2894 protect skeletal muscle from mitochondrial damages in a rat model of cisplatin-induced cachexia.
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-017-13504-y
– volume: 5
  year: 2014
  ident: B175
  article-title: Mitochondria dysfunction in lung cancer-induced muscle wasting in C2C12 myotubes.
  publication-title: Front. Physiol.
  doi: 10.3389/fphys.2014.00503
– volume: 21
  year: 2020
  ident: B272
  article-title: Impact of mitophagy and mitochondrial unfolded protein response as new adaptive mechanisms underlying old pathologies: sarcopenia and non-alcoholic fatty liver disease.
  publication-title: Int. J. Mol. Sci.
  doi: 10.3390/ijms21207704
– volume: 8
  start-page: 768
  year: 2017
  ident: B163
  article-title: Circulating Activin A predicts survival in cancer patients.
  publication-title: J. Cachexia Sarcopenia Muscle
  doi: 10.1002/jcsm.12209
– volume: 85
  start-page: 647
  year: 2007
  ident: B236
  article-title: Activity of the Akt-dependent anabolic and catabolic pathways in muscle and liver samples in cancer-related cachexia.
  publication-title: J. Mol. Med. Berl. Ger.
  doi: 10.1007/s00109-007-0177-2
– volume: 83
  start-page: 1857
  year: 1997
  ident: B9
  article-title: Growth hormone/IGF-I and/or resistive exercise maintains myonuclear number in hindlimb unweighted muscles.
  publication-title: J. Appl. Physiol. Bethesda Md 1985
  doi: 10.1152/jappl.1997.83.6.1857
– volume: 41
  year: 2020
  ident: B126
  article-title: Muscle NAD+ depletion and Serpina3n as molecular determinants of murine cancer cachexia-the effects of blocking myostatin and activins.
  publication-title: Mol. Metab.
  doi: 10.1016/j.molmet.2020.101046
– volume: 37
  start-page: 3325
  year: 2014
  ident: B104
  article-title: Changes in adipose tissue depots and metabolic markers following a 1-year diet and exercise intervention in overweight and obese patients with type 2 diabetes.
  publication-title: Diabetes Care
  doi: 10.2337/dc14-1585
– volume: 7
  year: 2017
  ident: B26
  article-title: ACVR2B/Fc counteracts chemotherapy-induced loss of muscle and bone mass.
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-017-15040-1
– volume: 33
  start-page: 1211
  year: 2009
  ident: B155
  article-title: Leisure-time physical activity and high-risk fat: a longitudinal population-based twin study.
  publication-title: Int. J. Obes. 2005
  doi: 10.1038/ijo.2009.170
– volume: 30
  start-page: 4234
  year: 2020
  ident: B225
  article-title: Muscle mass loss after neoadjuvant chemotherapy in breast cancer: estimation on breast magnetic resonance imaging using pectoralis muscle area.
  publication-title: Eur. Radiol.
  doi: 10.1007/s00330-020-06799-5
– volume: 13
  year: 2021
  ident: B153
  article-title: Association between skeletal muscle loss and the response to neoadjuvant chemotherapy for breast cancer.
  publication-title: Cancers
  doi: 10.3390/cancers13081806
– volume: 3
  start-page: 185
  ident: B53
  article-title: Formoterol treatment downregulates the myostatin system in skeletal muscle of cachectic tumour-bearing rats.
  publication-title: Oncol. Lett.
  doi: 10.3892/ol.2011.442
– volume: 40
  start-page: 1129
  year: 2018
  ident: B67
  article-title: Luteolin reduces cancer-induced skeletal and cardiac muscle atrophy in a Lewis lung cancer mouse model.
  publication-title: Oncol. Rep.
  doi: 10.3892/or.2018.6453
– volume: 128
  start-page: 1654
  year: 2020
  ident: B264
  article-title: Effect of neuromuscular electrical stimulation on skeletal muscle size and function in patients with breast cancer receiving chemotherapy.
  publication-title: J. Appl. Physiol.
  doi: 10.1152/japplphysiol.00203.2020
– volume: 232
  start-page: 3744
  year: 2017
  ident: B61
  article-title: Role of PARP activity in lung cancer-induced cachexia: effects on muscle oxidative stress, proteolysis, anabolic markers, and phenotype.
  publication-title: J. Cell. Physiol.
  doi: 10.1002/jcp.25851
– volume: 246
  year: 2020
  ident: B20
  article-title: Paeonia lactiflora root extract suppresses cancer cachexia by down-regulating muscular NF-κB signalling and muscle-specific E3 ubiquitin ligases in cancer-bearing mice.
  publication-title: J. Ethnopharmacol.
  doi: 10.1016/j.jep.2019.112222
– volume: 50
  start-page: 56
  year: 2016
  ident: B50
  article-title: Muscle wasting and aging: experimental models, fatty infiltrations, and prevention.
  publication-title: Mol. Aspects Med.
  doi: 10.1016/j.mam.2016.04.006
– volume: 98
  start-page: 1349
  year: 2013
  ident: B95
  article-title: Mitochondrial dysfunction and therapeutic approaches in respiratory and limb muscles of cancer cachectic mice.
  publication-title: Exp. Physiol.
  doi: 10.1113/expphysiol.2013.072496
– volume: 51
  start-page: 271
  year: 2019
  ident: B237
  article-title: Validation of the 6-min walk test for predicting peak V⋅O2 in cancer survivors.
  publication-title: Med. Sci. Sports Exerc.
  doi: 10.1249/MSS.0000000000001790
– volume: 22
  start-page: 2175
  year: 2018
  ident: B190
  article-title: Anthracycline and trastuzumab-induced cardiotoxicity in breast cancer.
  publication-title: Eur. Rev. Med. Pharmacol. Sci.
  doi: 10.26355/eurrev_201804_14752
– volume: 345
  start-page: 995
  year: 2001
  ident: B31
  article-title: Trastuzumab and breast cancer.
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJM200109273451312
– volume: 60
  start-page: 324
  year: 2005
  ident: B277
  article-title: Muscle mass, muscle strength, and muscle fat infiltration as predictors of incident mobility limitations in well-functioning older persons.
  publication-title: J. Gerontol. A. Biol. Sci. Med. Sci.
  doi: 10.1093/gerona/60.3.324
– volume: 6
  start-page: 197
  year: 2015
  ident: B48
  article-title: Skeletal muscle wasting in cachexia and sarcopenia: molecular pathophysiology and impact of exercise training.
  publication-title: J. Cachexia Sarcopenia Muscle
  doi: 10.1002/jcsm.12043
– volume: 3
  start-page: 265
  year: 2012
  ident: B139
  article-title: Cancer cachexia is associated with a decrease in skeletal muscle mitochondrial oxidative capacities without alteration of ATP production efficiency.
  publication-title: J. Cachexia Sarcopenia Muscle
  doi: 10.1007/s13539-012-0071-9
– volume: 6
  year: 2016
  ident: B120
  article-title: ActRII blockade protects mice from cancer cachexia and prolongs survival in the presence of anti-cancer treatments.
  publication-title: Skelet. Muscle
  doi: 10.1186/s13395-016-0098-2
– volume: 54
  start-page: 5568
  year: 1994
  ident: B261
  article-title: Increased ATP-ubiquitin-dependent proteolysis in skeletal muscles of tumor-bearing rats.
  publication-title: Cancer Res.
– volume: 11
  year: 2020
  ident: B12
  article-title: Evaluation of an antioxidant and anti-inflammatory cocktail against human hypoactivity-induced skeletal muscle deconditioning.
  publication-title: Front. Physiol.
  doi: 10.3389/fphys.2020.00071
– volume: 25
  start-page: e852
  year: 2020
  ident: B28
  article-title: Exercise intolerance in anthracycline-treated breast cancer survivors: the role of skeletal muscle bioenergetics, oxygenation, and composition.
  publication-title: The Oncologist
  doi: 10.1634/theoncologist.2019-0777
– volume: 111
  start-page: 2954
  year: 2020
  ident: B193
  article-title: Peptide-2 from mouse myostatin precursor protein alleviates muscle wasting in cancer-associated cachexia.
  publication-title: Cancer Sci.
  doi: 10.1111/cas.14520
– volume: 65
  start-page: 988
  year: 2013
  ident: B108
  article-title: The anticancer agent doxorubicin disrupts mitochondrial energy metabolism and redox balance in skeletal muscle.
  publication-title: Free Radic. Biol. Med.
  doi: 10.1016/j.freeradbiomed.2013.08.191
– volume: 142
  start-page: 531
  year: 2010
  ident: B298
  article-title: Reversal of cancer cachexia and muscle wasting by ActRIIB antagonism leads to prolonged survival.
  publication-title: Cell
  doi: 10.1016/j.cell.2010.07.011
– volume: 57
  start-page: 1006
  year: 2018
  ident: B142
  article-title: Time-course study of macrophage infiltration and inflammation in cast immobilization-induced atrophied muscle of mice.
  publication-title: Muscle Nerve
  doi: 10.1002/mus.26061
– volume: 7
  start-page: 458
  year: 2016
  ident: B226
  article-title: Loss of skeletal muscle during neoadjuvant chemotherapy is related to decreased survival in ovarian cancer patients.
  publication-title: J. Cachexia Sarcopenia Muscle
  doi: 10.1002/jcsm.12107
– volume: 24
  start-page: 511
  year: 2018
  ident: B91
  article-title: Breast cancer immunotherapy: facts and hopes.
  publication-title: Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res.
  doi: 10.1158/1078-0432.CCR-16-3001
– volume: 5
  start-page: 309
  year: 2020
  ident: B293
  article-title: Long-term cardiopulmonary consequences of treatment-induced cardiotoxicity in survivors of ERBB2-positive breast cancer.
  publication-title: JAMA Cardiol.
  doi: 10.1001/jamacardio.2019.5586
– volume: 13
  year: 2018
  ident: B68
  article-title: Prognostic value of systemic inflammatory markers and development of a nomogram in breast cancer.
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0200936
– volume: 48
  start-page: 16
  year: 2019
  ident: B77
  article-title: Sarcopenia: revised European consensus on definition and diagnosis.
  publication-title: Age Ageing
  doi: 10.1093/ageing/afy169
– volume: 2
  year: 2018
  ident: B138
  article-title: Skeletal muscle fibrosis in pancreatic cancer patients with respect to survival.
  publication-title: JNCI Cancer Spectr.
  doi: 10.1093/jncics/pky043
– volume: 21
  start-page: 1457
  year: 1998
  ident: B176
  article-title: Doxorubicin chemomyectomy as a treatment for cervical dystonia: histological assessment after direct injection into the sternocleidomastoid muscle.
  publication-title: Muscle Nerve
  doi: 10.1002/(SICI)1097-4598(199811)21:11<1457::AID-MUS14>3.0.CO;2-Y
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Snippet Breast cancer represents the most commonly diagnosed cancer while neoadjuvant and adjuvant chemotherapies are extensively used in order to reduce tumor...
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SubjectTerms cancer cachexia
Cell and Developmental Biology
inflammatory cytokines
intermuscular adipose tissue
mitochondria
muscle atrophy
protein turnover
Title Skeletal Muscle Deconditioning in Breast Cancer Patients Undergoing Chemotherapy: Current Knowledge and Insights From Other Cancers
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