RALB GTPase: a critical regulator of DR5 expression and TRAIL sensitivity in KRAS mutant colorectal cancer

RAS mutant (MT) metastatic colorectal cancer (mCRC) is resistant to MEK1/2 inhibition and remains a difficult-to-treat group. Therefore, there is an unmet need for novel treatment options for RAS MT mCRC. RALA and RALB GTPases function downstream of RAS and have been found to be key regulators of se...

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Vydané v:	Cell death & disease Ročník 11; číslo 10; s. 930
Hlavní autori:	Khawaja, Hajrah, Campbell, Andrew, Roberts, Jamie Z., Javadi, Arman, O’Reilly, Paul, McArt, Darragh, Allen, Wendy L., Majkut, Joanna, Rehm, Markus, Bardelli, Alberto, Di Nicolantonio, Federica, Scott, Christopher J., Kennedy, Richard, Vitale, Nicolas, Harrison, Timothy, Sansom, Owen J., Longley, Daniel B., Evergren, Emma, Van Schaeybroeck, Sandra
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	London Nature Publishing Group UK 29.10.2020 Springer Nature B.V Nature Publishing Group
Predmet:	13/2 13/31 13/89 14/19 38/109 38/79 42/70 631/67/1504/1885/1393 631/67/395 631/80/82/23 82/80 96/106 96/95 Antibodies Antineoplastic Combined Chemotherapy Protocols - pharmacology Apoptosis Benzimidazoles - administration & dosage Biochemistry Biomedical and Life Sciences Cancer Caspase-8 Cell Biology Cell Culture Cell death Cell surface Cellular Biology Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - drug therapy Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism DR5 protein GTP Phosphohydrolases - metabolism Humans Immunology K-Ras protein Life Sciences Lysosomes Metastases mRNA Mutants Mutation Proto-Oncogene Proteins p21(ras) - genetics Proto-Oncogene Proteins p21(ras) - metabolism ral GTP-Binding Proteins - antagonists & inhibitors ral GTP-Binding Proteins - biosynthesis ral GTP-Binding Proteins - genetics ral GTP-Binding Proteins - metabolism RalA protein Ras protein Receptors, TNF-Related Apoptosis-Inducing Ligand - agonists Receptors, TNF-Related Apoptosis-Inducing Ligand - metabolism Recombinant Proteins - pharmacology RNA, Messenger - genetics RNA, Messenger - metabolism RNA-mediated interference Signal transduction TNF-Related Apoptosis-Inducing Ligand - administration & dosage TNF-Related Apoptosis-Inducing Ligand - pharmacology Transfection Tumorigenesis
ISSN:	2041-4889, 2041-4889
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