Brain morphometry reproducibility in multi-center 3T MRI studies: A comparison of cross-sectional and longitudinal segmentations

Large-scale longitudinal multi-site MRI brain morphometry studies are becoming increasingly crucial to characterize both normal and clinical population groups using fully automated segmentation tools. The test–retest reproducibility of morphometry data acquired across multiple scanning sessions, and...

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Vydané v:NeuroImage (Orlando, Fla.) Ročník 83; s. 472 - 484
Hlavní autori: Jovicich, Jorge, Marizzoni, Moira, Sala-Llonch, Roser, Bosch, Beatriz, Bartrés-Faz, David, Arnold, Jennifer, Benninghoff, Jens, Wiltfang, Jens, Roccatagliata, Luca, Nobili, Flavio, Hensch, Tilman, Tränkner, Anja, Schönknecht, Peter, Leroy, Melanie, Lopes, Renaud, Bordet, Régis, Chanoine, Valérie, Ranjeva, Jean-Philippe, Didic, Mira, Gros-Dagnac, Hélène, Payoux, Pierre, Zoccatelli, Giada, Alessandrini, Franco, Beltramello, Alberto, Bargalló, Núria, Blin, Olivier, Frisoni, Giovanni B.
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States Elsevier Inc 01.12.2013
Elsevier Limited
Elsevier
Predmet:
Aging - pathology
Algorithms
Automation
Biomarkers
Brain
Brain - anatomy & histology
Brain morphometry
Cognitive science
Cross-Sectional Studies
Europe
Female
Humans
Image Enhancement - methods
Image Interpretation, Computer-Assisted - methods
Longitudinal Studies
Magnetic Resonance Imaging - methods
Male
Medical imaging
Multi-center
Multi-site MRI
Pattern Recognition, Automated - methods
Physics
Reliability
Reproducibility
Reproducibility of Results
Scanners
Sensitivity and Specificity
Standard deviation
Structural MRI
Studies
Europe
Multi-center
Structural MRI
Multi-site MRI
Brain morphometry
Reliability
Reproducibility
ISSN:1053-8119, 1095-9572, 1095-9572
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Shrnutí:Large-scale longitudinal multi-site MRI brain morphometry studies are becoming increasingly crucial to characterize both normal and clinical population groups using fully automated segmentation tools. The test–retest reproducibility of morphometry data acquired across multiple scanning sessions, and for different MR vendors, is an important reliability indicator since it defines the sensitivity of a protocol to detect longitudinal effects in a consortium. There is very limited knowledge about how across-session reliability of morphometry estimates might be affected by different 3T MRI systems. Moreover, there is a need for optimal acquisition and analysis protocols in order to reduce sample sizes. A recent study has shown that the longitudinal FreeSurfer segmentation offers improved within session test–retest reproducibility relative to the cross-sectional segmentation at one 3T site using a nonstandard multi-echo MPRAGE sequence. In this study we implement a multi-site 3T MRI morphometry protocol based on vendor provided T1 structural sequences from different vendors (3D MPRAGE on Siemens and Philips, 3D IR-SPGR on GE) implemented in 8 sites located in 4 European countries. The protocols used mild acceleration factors (1.5–2) when possible. We acquired across-session test–retest structural data of a group of healthy elderly subjects (5 subjects per site) and compared the across-session reproducibility of two full-brain automated segmentation methods based on either longitudinal or cross-sectional FreeSurfer processing. The segmentations include cortical thickness, intracranial, ventricle and subcortical volumes. Reproducibility is evaluated as absolute changes relative to the mean (%), Dice coefficient for volume overlap and intraclass correlation coefficients across two sessions. We found that this acquisition and analysis protocol gives comparable reproducibility results to previous studies that used longer acquisitions without acceleration. We also show that the longitudinal processing is systematically more reliable across sites regardless of MRI system differences. The reproducibility errors of the longitudinal segmentations are on average approximately half of those obtained with the cross sectional analysis for all volume segmentations and for entorhinal cortical thickness. No significant differences in reliability are found between the segmentation methods for the other cortical thickness estimates. The average of two MPRAGE volumes acquired within each test–retest session did not systematically improve the across-session reproducibility of morphometry estimates. Our results extend those from previous studies that showed improved reliability of the longitudinal analysis at single sites and/or with non-standard acquisition methods. The multi-site acquisition and analysis protocol presented here is promising for clinical applications since it allows for smaller sample sizes per MRI site or shorter trials in studies evaluating the role of potential biomarkers to predict disease progression or treatment effects. •We implemented a multi-site 3T MRI protocol for brain morphometry on 8EU sites.•We acquired across-session test-retest data on 40 healthy elderly subjects.•We calculated the reproducibility of cortical and volumetric FreeSurfer estimates.•Longitudinal segmentation was more reliable than cross-sectional on all sites.
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ISSN:1053-8119
1095-9572
1095-9572
DOI:10.1016/j.neuroimage.2013.05.007