Structure of the miniature type V-F CRISPR-Cas effector enzyme

RNA-guided DNA endonucleases derived from CRISPR-Cas adaptive immune systems are widely used as powerful genome-engineering tools. Among the diverse CRISPR-Cas nucleases, the type V-F Cas12f (also known as Cas14) proteins are exceptionally compact and associate with a guide RNA to cleave single- and...

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Veröffentlicht in:	Molecular cell Jg. 81; H. 3; S. 558
Hauptverfasser:	Takeda, Satoru N, Nakagawa, Ryoya, Okazaki, Sae, Hirano, Hisato, Kobayashi, Kan, Kusakizako, Tsukasa, Nishizawa, Tomohiro, Yamashita, Keitaro, Nishimasu, Hiroshi, Nureki, Osamu
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 04.02.2021
Schlagworte:	Clustered Regularly Interspaced Short Palindromic Repeats CRISPR-Associated Proteins - genetics CRISPR-Associated Proteins - metabolism CRISPR-Associated Proteins - ultrastructure CRISPR-Cas Systems Cryoelectron Microscopy DNA - genetics DNA - metabolism DNA - ultrastructure Gene Editing Models, Molecular Nucleotide Motifs Protein Binding Protein Interaction Domains and Motifs Protein Multimerization Protein Subunits RNA, Guide, CRISPR-Cas Systems - genetics RNA, Guide, CRISPR-Cas Systems - metabolism RNA, Guide, CRISPR-Cas Systems - ultrastructure Structure-Activity Relationship Cas12f CRISPR-Cas genome editing Cryo-EM
ISSN:	1097-4164, 1097-4164
Online-Zugang:	Weitere Angaben
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