Polyphenols’ Impact on Selected Biomarkers of Brain Aging in Healthy Middle-Aged and Elderly Subjects: A Review of Clinical Trials

With a constantly growing elderly population, incidences of neurodegenerative diseases are also rising and are expected to further increase over the next years, while costing health systems across the world trillions of dollars. Therefore, biomarkers to detect manifestations of brain aging early and...

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Published in:	Nutrients Vol. 15; no. 17; p. 3770
Main Authors:	Ziegler, Tobias, Tsiountsioura, Melina, Meixner-Goetz, Lisa, Cvirn, Gerhard, Lamprecht, Manfred
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 29.08.2023 MDPI
Subjects:	Aged Aging Alzheimer's disease Amyloid beta-Peptides antioxidants Biological markers Biomarkers Blood Brain Brain - diagnostic imaging Brain-Derived Neurotrophic Factor Clinical trials cognition elderly hematologic tests Humans Kinases magnetism Medical examination Middle Aged Nerve Growth Factor Nervous system diseases Older people Polyphenols positron-emission tomography Proteins Review amyloid-beta Aβ polyphenols BDNF brain aging tau NGF flavonoids resveratrol curcumin
ISSN:	2072-6643, 2072-6643
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Abstract	With a constantly growing elderly population, incidences of neurodegenerative diseases are also rising and are expected to further increase over the next years, while costing health systems across the world trillions of dollars. Therefore, biomarkers to detect manifestations of brain aging early and interventions to slow down its pace are of great interest. In the last years, the importance of the neurotrophins brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in the context of cognitive function and the aging brain has increased, besides the already well-established amyloid-beta (Aβ) and tau plaques. Due to their wide range of beneficial health effects as well as their antioxidant and anti-inflammatory properties, a class of secondary plant-metabolites, the so-called polyphenols, gained increasing attention. In this review, we discuss the roles of BDNF, Aβ, NGF, and tau proteins as biomarkers of brain aging and the effect of dietary polyphenol interventions on these biomarkers, assessed via blood analysis, magnetic resonance imaging (MRI), and positron emission tomography (PET).
AbstractList	With a constantly growing elderly population, incidences of neurodegenerative diseases are also rising and are expected to further increase over the next years, while costing health systems across the world trillions of dollars. Therefore, biomarkers to detect manifestations of brain aging early and interventions to slow down its pace are of great interest. In the last years, the importance of the neurotrophins brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in the context of cognitive function and the aging brain has increased, besides the already well-established amyloid-beta (Aβ) and tau plaques. Due to their wide range of beneficial health effects as well as their antioxidant and anti-inflammatory properties, a class of secondary plant-metabolites, the so-called polyphenols, gained increasing attention. In this review, we discuss the roles of BDNF, Aβ, NGF, and tau proteins as biomarkers of brain aging and the effect of dietary polyphenol interventions on these biomarkers, assessed via blood analysis, magnetic resonance imaging (MRI), and positron emission tomography (PET). With a constantly growing elderly population, incidences of neurodegenerative diseases are also rising and are expected to further increase over the next years, while costing health systems across the world trillions of dollars. Therefore, biomarkers to detect manifestations of brain aging early and interventions to slow down its pace are of great interest. In the last years, the importance of the neurotrophins brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in the context of cognitive function and the aging brain has increased, besides the already well-established amyloid-beta (Aβ) and tau plaques. Due to their wide range of beneficial health effects as well as their antioxidant and anti-inflammatory properties, a class of secondary plant-metabolites, the so-called polyphenols, gained increasing attention. In this review, we discuss the roles of BDNF, Aβ, NGF, and tau proteins as biomarkers of brain aging and the effect of dietary polyphenol interventions on these biomarkers, assessed via blood analysis, magnetic resonance imaging (MRI), and positron emission tomography (PET).With a constantly growing elderly population, incidences of neurodegenerative diseases are also rising and are expected to further increase over the next years, while costing health systems across the world trillions of dollars. Therefore, biomarkers to detect manifestations of brain aging early and interventions to slow down its pace are of great interest. In the last years, the importance of the neurotrophins brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in the context of cognitive function and the aging brain has increased, besides the already well-established amyloid-beta (Aβ) and tau plaques. Due to their wide range of beneficial health effects as well as their antioxidant and anti-inflammatory properties, a class of secondary plant-metabolites, the so-called polyphenols, gained increasing attention. In this review, we discuss the roles of BDNF, Aβ, NGF, and tau proteins as biomarkers of brain aging and the effect of dietary polyphenol interventions on these biomarkers, assessed via blood analysis, magnetic resonance imaging (MRI), and positron emission tomography (PET).
Audience	Academic
Author	Ziegler, Tobias Lamprecht, Manfred Tsiountsioura, Melina Meixner-Goetz, Lisa Cvirn, Gerhard
AuthorAffiliation	1 Division of Medicinal Chemistry, Otto Loewi Research Center, Medical University of Graz, 8010 Graz, Austria; tobias.ziegler@jpsi.info (T.Z.); melina.tsiountsioura@jpsi.info (M.T.); gerhard.cvirn@medunigraz.at (G.C.) 3 Green Beat Institute of Nutrient Research, 8010 Graz, Austria 2 Juice Plus+ Science Institute, Memphis, TN 38017, USA; lisa.meixner-goetz@jpsi.info
AuthorAffiliation_xml	– name: 2 Juice Plus+ Science Institute, Memphis, TN 38017, USA; lisa.meixner-goetz@jpsi.info – name: 3 Green Beat Institute of Nutrient Research, 8010 Graz, Austria – name: 1 Division of Medicinal Chemistry, Otto Loewi Research Center, Medical University of Graz, 8010 Graz, Austria; tobias.ziegler@jpsi.info (T.Z.); melina.tsiountsioura@jpsi.info (M.T.); gerhard.cvirn@medunigraz.at (G.C.)
Author_xml	– sequence: 1 givenname: Tobias orcidid: 0000-0001-8235-9284 surname: Ziegler fullname: Ziegler, Tobias – sequence: 2 givenname: Melina surname: Tsiountsioura fullname: Tsiountsioura, Melina – sequence: 3 givenname: Lisa surname: Meixner-Goetz fullname: Meixner-Goetz, Lisa – sequence: 4 givenname: Gerhard orcidid: 0000-0002-1410-1844 surname: Cvirn fullname: Cvirn, Gerhard – sequence: 5 givenname: Manfred surname: Lamprecht fullname: Lamprecht, Manfred
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Snippet	With a constantly growing elderly population, incidences of neurodegenerative diseases are also rising and are expected to further increase over the next...
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SubjectTerms	Aged Aging Alzheimer's disease Amyloid beta-Peptides antioxidants Biological markers Biomarkers Blood Brain Brain - diagnostic imaging Brain-Derived Neurotrophic Factor Clinical trials cognition elderly hematologic tests Humans Kinases magnetism Medical examination Middle Aged Nerve Growth Factor Nervous system diseases Older people Polyphenols positron-emission tomography Proteins Review
Title	Polyphenols’ Impact on Selected Biomarkers of Brain Aging in Healthy Middle-Aged and Elderly Subjects: A Review of Clinical Trials
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