BMP6 binding to heparin and heparan sulfate is mediated by N-terminal and C-terminal clustered basic residues

The bone morphogenetic protein 6 (BMP6) is a crucial inducer of hepcidin, the peptide hormone that regulates the iron availability in our body. Hepcidin expression is influenced by hepatic heparan sulfate (HS) and by heparin administration, suggesting BMP6 interaction with heparin/HS. The BMP2/4 sub...

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Bibliographic Details
Published in:	Biochimica et biophysica acta. General subjects Vol. 1865; no. 2; p. 129799
Main Authors:	Denardo, Andrea, Elli, Stefano, Federici, Stefania, Asperti, Michela, Gryzik, Magdalena, Ruzzenenti, Paola, Carmona, Fernando, Bergese, Paolo, Naggi, Annamaria, Arosio, Paolo, Poli, Maura
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.02.2021
Subjects:	Animals Binding Sites Bone morphogenetic protein 6 (BMP6) Bone Morphogenetic Protein 6 - chemistry Bone Morphogenetic Protein 6 - metabolism bone morphogenetic proteins CHO Cells computer simulation Cricetulus Hep G2 Cells Heparan sulfate Heparin Heparin - metabolism Heparitin Sulfate - metabolism Hepcidin Hepcidins - metabolism Humans Interaction Models, Molecular mutation Protein Binding Protein Interaction Domains and Motifs sulfates Heparan sulfate HSPG Interaction Bone morphogenetic protein 6 (BMP6) HS HBD GAG BMP6 DS CS MD Heparin SEC-TDA Hepcidin
ISSN:	0304-4165, 1872-8006, 1872-8006
Online Access:	Get full text
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