Meta-analysis of Icelandic and UK data sets identifies missense variants in SMO, IL11, COL11A1 and 13 more new loci associated with osteoarthritis

Osteoarthritis has a highly negative impact on quality of life because of the associated pain and loss of joint function. Here we describe the largest meta-analysis so far of osteoarthritis of the hip and the knee in samples from Iceland and the UK Biobank (including 17,151 hip osteoarthritis patien...

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Veröffentlicht in:	Nature genetics Jg. 50; H. 12; S. 1681 - 1687
Hauptverfasser:	Styrkarsdottir, Unnur, Lund, Sigrun H., Thorleifsson, Gudmar, Zink, Florian, Stefansson, Olafur A., Sigurdsson, Jon K., Juliusson, Kristinn, Bjarnadottir, Kristbjörg, Sigurbjornsdottir, Sara, Jonsson, Stefan, Norland, Kristjan, Stefansdottir, Lilja, Sigurdsson, Asgeir, Sveinbjornsson, Gardar, Oddsson, Asmundur, Bjornsdottir, Gyda, Gudmundsson, Reynir L., Halldorsson, Gisli H., Rafnar, Thorunn, Jonsdottir, Ingileif, Steingrimsson, Eirikur, Norddahl, Gudmundur L., Masson, Gisli, Sulem, Patrick, Jonsson, Helgi, Ingvarsson, Thorvaldur, Gudbjartsson, Daniel F., Thorsteinsdottir, Unnur, Stefansson, Kari
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	New York Nature Publishing Group US 01.12.2018 Nature Publishing Group
Schlagworte:	45/23 45/43 631/208/1516 631/208/205/2138 631/208/457 692/699/1670 692/699/67 Adult Aged Agriculture Analysis Animal Genetics and Genomics Arthritis Biocompatibility Biomedical and Life Sciences Biomedicine Cancer Research Case-Control Studies Collagen Type XI - genetics Consortia Datasets Datasets as Topic - statistics & numerical data Deoxyribonucleic acid Disease DNA Female Gene expression Gene Frequency Gene Function Genes Genetic aspects Genetic Loci Genetic Predisposition to Disease Genetic variation Genetics Genome-Wide Association Study Genomes Genotype Haplotypes Health aspects Hip Human Genetics Humans Iceland - epidemiology Influence Interleukin 1 Interleukin 11 Interleukin-11 - genetics Knee Letter Loci Male Meta-analysis Middle Aged Mutation Mutation, Missense Osteoarthritis Osteoarthritis - epidemiology Osteoarthritis - genetics Pain Patients Polymorphism, Single Nucleotide Quality of life Risk factors Smoothened Receptor - genetics United Kingdom - epidemiology United Kingdom Iceland United Kingdom > UK
ISSN:	1061-4036, 1546-1718, 1546-1718
Online-Zugang:	Volltext
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