Cellular Models of Aging and Senescence

Aging, a state of progressive decline in physiological function, is an important risk factor for chronic diseases, ranging from cancer and musculoskeletal frailty to cardiovascular and neurodegenerative diseases. Understanding its cellular basis is critical for developing interventions to extend hum...

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Bibliographic Details
Published in:	Cells (Basel, Switzerland) Vol. 14; no. 16; p. 1278
Main Authors:	Kim, Byunggik, Lee, Dong I., Basisty, Nathan, Dai, Dao-Fu
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 18.08.2025 MDPI
Subjects:	Age Aging Animals Atazanavir Autophagy Biological clocks Cell culture cellular aging Cellular Senescence Chronic diseases Disease DNA damage Epigenetic inheritance epigenetic reprogramming Epigenetics Fibroblasts Humans induced pluripotent stem cells (iPSCs) Induced Pluripotent Stem Cells - metabolism Kinases Medical research Medicine, Experimental Metabolism Mitochondria - metabolism mitochondrial dysfunction Models, Biological Nervous system diseases Neurodegenerative diseases Phenotypes Physiology Pluripotency Progeroid syndromes Review Risk factors Senescence Senescence-Associated Secretory Phenotype senolytics Stem cells senescence progeroid syndromes cardiovascular aging in vitro models cellular aging neurodegeneration senolytics epigenetic reprogramming mitochondrial dysfunction induced pluripotent stem cells (iPSCs)
ISSN:	2073-4409, 2073-4409
Online Access:	Get full text
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