LncRNA-mediated regulation of cell signaling in cancer

To date, a large number of long non-coding RNAs (lncRNAs) have been recently discovered through functional genomics studies. Importantly, lncRNAs have been shown, in many cases, to function as master regulators for gene expression and thus, they can play a critical role in various biological functio...

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Veröffentlicht in:Oncogene Jg. 36; H. 41; S. 5661 - 5667
Hauptverfasser: Peng, W-X, Koirala, P, Mo, Y-Y
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London Nature Publishing Group UK 12.10.2017
Nature Publishing Group
Schlagworte:
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Apoptosis
Cancer
Cancer cells
Cell Biology
Cell signaling
Cellular signal transduction
Gene expression
Gene Expression Regulation, Neoplastic
Gene regulation
Genetic aspects
Genomics
Human Genetics
Humans
Internal Medicine
Medicine
Medicine & Public Health
Neoplasms - genetics
Non-coding RNA
Oncology
Physiological aspects
Proteins
review
Ribonucleic acid
RNA
RNA, Long Noncoding - genetics
Signal Transduction - genetics
Transcription
Transcription (Genetics)
ISSN:0950-9232, 1476-5594, 1476-5594
Online-Zugang:Volltext
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Beschreibung
Zusammenfassung:To date, a large number of long non-coding RNAs (lncRNAs) have been recently discovered through functional genomics studies. Importantly, lncRNAs have been shown, in many cases, to function as master regulators for gene expression and thus, they can play a critical role in various biological functions and disease processes including cancer. Although the lncRNA-mediated gene expression involves various mechanisms, such as regulation of transcription, translation, protein modification, and the formation of RNA–protein or protein–protein complexes, in this review, we discuss the latest developments primarily in important cell signaling pathways regulated by lncRNAs in cancer.
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ISSN:0950-9232
1476-5594
1476-5594
DOI:10.1038/onc.2017.184