3D imaging by mass spectrometry: a new frontier

Imaging mass spectrometry can generate three-dimensional volumes showing molecular distributions in an entire organ or animal through registration and stacking of serial tissue sections. Here, we review the current state of 3D imaging mass spectrometry as well as provide insights and perspectives on...

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Bibliographic Details
Published in:Analytical chemistry (Washington) Vol. 84; no. 5; p. 2105
Main Authors: Seeley, Erin H, Caprioli, Richard M
Format: Journal Article
Language:English
Published: United States 06.03.2012
Subjects:
Animals
Brain - anatomy & histology
Humans
Imaging, Three-Dimensional
Magnetic Resonance Imaging
Peptides - chemistry
Proteins - chemistry
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Spectrometry, Mass, Secondary Ion
ISSN:1520-6882, 1520-6882
Online Access:Get more information
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Summary:Imaging mass spectrometry can generate three-dimensional volumes showing molecular distributions in an entire organ or animal through registration and stacking of serial tissue sections. Here, we review the current state of 3D imaging mass spectrometry as well as provide insights and perspectives on the process of generating 3D mass spectral data along with a discussion of the process necessary to generate a 3D image volume.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
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ISSN:1520-6882
1520-6882
DOI:10.1021/ac2032707