Interactions between natural products and cancer treatments: underlying mechanisms and clinical importance

Natural products, also referred to as dietary supplements, complementary and alternative medicines, and health or food supplements are widely used by people living with cancer. These products are predominantly self-selected and taken concurrently with cancer treatments with the intention of improvin...

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Bibliographic Details
Published in:Cancer chemotherapy and pharmacology Vol. 91; no. 2; pp. 103 - 119
Main Authors: Chan, Wai-Jo Jocelin, Adiwidjaja, Jeffry, McLachlan, Andrew J., Boddy, Alan V., Harnett, Joanna E.
Format: Journal Article
Language:English
Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.02.2023
Springer Nature B.V
Subjects:
Biological Products
Cancer
Cancer Research
Cancer therapies
Clinical outcomes
Clinical Relevance
Curcuma longa
Diarrhea
Dietary Supplements
Drug-Related Side Effects and Adverse Reactions
grapefruits
Herb-Drug Interactions
Humans
Hydrastis canadensis
Hypericum perforatum
Immune response
Medicine
Medicine & Public Health
Mucositis
Natural products
Neoplasms
Oncology
Pharmacodynamics
Pharmacokinetics
Pharmacology/Toxicology
Quality of Life
Review
Review Article
Schisandra
Side effects
Chemotherapy
Interactions
Natural products
Complementary medicines
Herbal medicines
Cancer
ISSN:0344-5704, 1432-0843, 1432-0843
Online Access:Get full text
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Summary:Natural products, also referred to as dietary supplements, complementary and alternative medicines, and health or food supplements are widely used by people living with cancer. These products are predominantly self-selected and taken concurrently with cancer treatments with the intention of improving quality of life, immune function and reducing cancer symptoms and treatment side effects. Concerns have been raised that concurrent use may lead to interactions resulting in adverse effects and unintended treatment outcomes. This review provides an overview of the mechanisms by which these interactions can occur and the current evidence about specific clinically important natural product–drug interactions. Clinical studies investigating pharmacokinetic interactions provide evidence that negative treatment outcomes may occur when Hypericum perforatum , Grapefruit, Schisandra sphenanthera, Curcuma longa or Hydrastis canadensis are taken concurrently with common cancer treatments. Conversely, pharmacodynamic interactions between Hangeshashinto (TJ-14) and some cancer treatments have been shown to reduce the side effects of diarrhoea and oral mucositis. In summary, research in this area is limited and requires further investigation.
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ISSN:0344-5704
1432-0843
1432-0843
DOI:10.1007/s00280-023-04504-z